Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Masato Koike"'
Autor:
Masato Koike, Hidetoshi Nojiri, Hiroaki Kanazawa, Mamiko Sawa, Kei Miyagawa, Hiroto Yamaguchi, Yoshiyuki Iwase, Hisashi Kurosawa, Kazuo Kaneko, Muneaki Ishijima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Recently, we found significantly reduced total superoxide dismutase (SOD) activity in the cartilage of patients with end-stage knee osteoarthritis (OA). In this study, we aimed to evaluate the SOD activity in serum, joint fluid, cartilage, a
Externí odkaz:
https://doaj.org/article/1221866f674c4174a2758c6650e46880
Autor:
Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, Masato Koike, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanabe
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103091- (2024)
Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been shown to contribute to IVD degeneration, the underlying mechanisms remain undetermined. Thi
Externí odkaz:
https://doaj.org/article/902f516d23074c69809ad465ad9459d4
Autor:
Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C. Meyer, Taroh Kinoshita
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101176- (2024)
Thirty genes are involved in the biosynthesis and modification of glycosylphosphatidylinositol (GPI)-anchored proteins, and defects in these genes cause inherited GPI deficiency (IGD). PIGA is X-linked and involved in the first step of GPI biosynthes
Externí odkaz:
https://doaj.org/article/181bb1efa9434f12a9c25cb49690553b
Autor:
Norihito Uemura, Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated
Externí odkaz:
https://doaj.org/article/c249b84834e1414cabb7db6ae3c525cf
Autor:
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disea
Externí odkaz:
https://doaj.org/article/4aa9abf1f0a54d21b9a3929c6aafe40d
Autor:
Kazuki Okamoto, Yuji Kamikubo, Kenta Yamauchi, Shinichiro Okamoto, Megumu Takahashi, Yoko Ishida, Masato Koike, Yuji Ikegaya, Takashi Sakurai, Hiroyuki Hioki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Given its limited accessibility, the CA2 area has been less investigated compared to other subregions of the hippocampus. While the development of transgenic mice expressing Cre recombinase in the CA2 has revealed unique features of this are
Externí odkaz:
https://doaj.org/article/3a8f624fb84e4f839b03ebdf53eba82f
Autor:
Kenta Yamauchi, Shinichiro Okamoto, Yoko Ishida, Kohtarou Konno, Kisara Hoshino, Takahiro Furuta, Megumu Takahashi, Masato Koike, Kaoru Isa, Masahiko Watanabe, Tadashi Isa, Hiroyuki Hioki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Tyramide signal amplification (TSA) is a highly sensitive method for histochemical analysis. Previously, we reported a TSA system, biotinyl tyramine-glucose oxidase (BT-GO), for bright-filed imaging. Here, we develop fluorochromized tyramide
Externí odkaz:
https://doaj.org/article/de14391ad4aa4ee1ac5b140c4236f532
Protocol for multi-scale light microscopy/electron microscopy neuronal imaging in mouse brain tissue
Autor:
Kenta Yamauchi, Takahiro Furuta, Shinichiro Okamoto, Megumu Takahashi, Masato Koike, Hiroyuki Hioki
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101508- (2022)
Summary: An imaging technique across multiple spatial scales is required for extracting structural information on neurons with processes of meter scale length and specialized nanoscale structures. Here, we present a protocol combining multi-scale lig
Externí odkaz:
https://doaj.org/article/3958657cf0774883b3983c86315b4e08
Autor:
Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitocho
Externí odkaz:
https://doaj.org/article/0b00ee531f2040729435d60ecf707a02
Autor:
Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned li
Externí odkaz:
https://doaj.org/article/254e1803533c4a90b127c4e96c993a34