Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Masato Higashino"'
Autor:
Tetsuya Yasuhiro, Masato Higashino, Keisuke Hazama, Scott A. Maidment, Miki Nakanishi, Nobuto Nakanishi, Mark S. Chambers, Gary Clark, Seishi Katsumata, Soichi Kawaharada, Shuji Kaneko, Arwel Lewis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:58-65
GABAA receptors containing α5 subunits (GABAAα5) are highly expressed in the hippocampus and negatively involved in memory processing, as shown by the fact that GABAAα5–deficient mice show higher hippocampus-dependent performance than wild-type
Autor:
Yoshiyuki Aratani, Hidekazu Matsuya, Koji Yoshida, Masato Higashino, Atsushi Naganawa, Hiroyuki Takeda, Akihiro Kinoshita, Keisuke Hanada, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:200-214
A highly potent and well-balanced dual agonist for the EP2 and EP3 receptors is described. Optimization of the lead compound was accomplished in consideration of the relative agonist activity against each EP subtype receptor and the pharmacokinetic p
Autor:
Naoko Ikeda, Kazuhiko Sakaguchi, Takahiro Nishimura, Shoma Ariyoshi, Shunnichi Kubota, Tetsuro Shinada, Yasufumi Ohfune, Wataru Akagi, Masato Higashino
Publikováno v:
Chemical communications (Cambridge, England). 55(59)
Acid-catalyzed intramolecular Friedel–Crafts cyclization of optically active α-hydroxy-α-alkenylsilanes possessing a benzene ring (>99% ee) with TMSOTf as a Lewis acid gave enantio-enriched tetrahydronaphthalenes (up to 98% ee). The silyl group a
Autor:
Hidekazu Matsuya, Yoshiyuki Aratani, Masato Higashino, Akihiro Kinoshita, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1016-1019
The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-pr
Autor:
Soichi, Kawaharada, Miki, Nakanishi, Nobuto, Nakanishi, Keisuke, Hazama, Masato, Higashino, Tetsuya, Yasuhiro, Arwel, Lewis, Gary S, Clark, Mark S, Chambers, Scott A, Maidment, Seishi, Katsumata, Shuji, Kaneko
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 366(1)
GABA
Autor:
Akihiro, Kinoshita, Masato, Higashino, Koji, Yoshida, Yoshiyuki, Aratani, Akito, Kakuuchi, Keisuke, Hanada, Hiroyuki, Takeda, Atsushi, Naganawa, Hidekazu, Matsuya, Kazuyuki, Ohmoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(1)
A highly potent and well-balanced dual agonist for the EP
Autor:
Miki Nakanishi, Kim Louise Hirst, Tetsuya Yasuhiro, Nobuto Nakanishi, Scott A. Maidment, Masato Higashino, Seishi Katsumata, Gary Clark, Mark Stuart Chambers, Soichi Kawaharada, Arwel Lewis, Keisuke Hazama, Grant Wishart
Publikováno v:
Alzheimer's & Dementia. 12
Publikováno v:
Tetrahedron Letters. 52:422-425
A novel silyl group-directed anti-SN2′ reaction of allylic alcohols under Mitsunobu reaction conditions is described. The Mitsunobu reaction of α-hydroxy-α-alkenylsilanes with a TBS or TIPS group gave the anti-SN2′ product, in which regio- and
Autor:
Taiki Umezawa, Masato Higashino, Yasufumi Ohfune, Makoto Hamada, Tetsuro Shinada, Kota Miyoshi
Publikováno v:
Synlett. 2010:2141-2145
K 2 HPO 4 is an efficient catalyst for thetransesterification reaction to produce methyl esters. Various functionalgroups are compatible under the mild reaction conditions.
Autor:
Miki Nakanishi, Nobuto Nakanishi, Scott A. Maidment, Keisuke Hazama, Arwel Lewis, Masato Higashino, Tetsuya Yasuhiro, Mark Stuart Chambers, Alastair Rae, Gary Clark, Soichi Kawaharada, Seishi Katsumata, Kim Louise Hirst, Grant Wishart
Publikováno v:
Alzheimer's & Dementia. 11