Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Masato Fujioka"'
Autor:
Chika Saegusa, Hideki Mutai, Tsubasa Saeki, Saeko Matsuzaki, Akifumi Mizukoshi, Shin-ichiro Kitajiri, Tatsuo Matsunaga, Makoto Hosoya, Hideyuki Okano, Masato Fujioka
Publikováno v:
Stem Cell Research, Vol 79, Iss , Pp 103489- (2024)
Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural heari
Externí odkaz:
https://doaj.org/article/7fec7d0c2ef64f9eb5fda29de5d42d28
Autor:
Yusuke Masano, Chika Saegusa, Mitsuru Ishikawa, Tatsuo Matsunaga, Hideyuki Okano, Masato Fujioka
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103452- (2024)
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established
Externí odkaz:
https://doaj.org/article/a3fc1b1467a04b1eabb9cad2805855bd
Autor:
Naoki Oishi, Masaru Noguchi, Masato Fujioka, Kiyomitsu Nara, Koichiro Wasano, Hideki Mutai, Rie Kawakita, Ryota Tamura, Kosuke Karatsu, Yukina Morimoto, Masahiro Toda, Hiroyuki Ozawa, Tatsuo Matsunaga
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract NF2-related schwannomatosis (NF2) is an autosomal dominant genetic disorder caused by variants in the NF2 gene. Approximately 50% of NF2 patients inherit pathogenic variants, and the remainder acquire de novo variants. NF2 is characterized b
Externí odkaz:
https://doaj.org/article/c7430bcd3051471daf89fb06f12545aa
Autor:
Sho Kurihara, Masayoshi Tei, Junichi Hata, Eri Mori, Masato Fujioka, Yoshinori Matsuwaki, Nobuyoshi Otori, Hiromi Kojima, Hirotaka James Okano
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Combined high-field MRI and DTI analyses in post-mortem mouse, marmoset, and human samples provide insight into the neural connections between nasal cavities and olfactory bulbs.
Externí odkaz:
https://doaj.org/article/b175753aac28400bbf226021fb9018e5
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
IntroductionThe well-regulated development of the sensory epithelium is essential for hearing. This process involves the specification of a pro-sensory epithelium containing common progenitors that differentiate into hair and supporting cells. Notch
Externí odkaz:
https://doaj.org/article/e2a205f9bec945ff82a7a08f12ac870d
Autor:
Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano
Publikováno v:
Regenerative Therapy, Vol 20, Iss , Pp 165-186 (2022)
Introduction: Efficient induction of the otic placode, the developmental origin of the inner ear from human pluripotent stem cells (hPSCs), provides a robust platform for otic development and sensorineural hearing loss modelling. Nevertheless, there
Externí odkaz:
https://doaj.org/article/8f164e0c0729489aa06876e4cf1c3290
Autor:
Shota Okura, Honoka Ishii, Ayano Suzuki, Chika Saegusa, Ko Fujiki, Kenshi Sugano, Noriomi Suzuki, Tsubasa Saeki, Saeko Matsuzaki, Hiroyuki Ozawa, Masato Fujioka, Makoto Hosoya, Hideyuki Okano
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103017- (2023)
We report the establishment of two human induced pluripotent stem cell (iPSC) lines from individuals without auditory disorders. Extensive audiometry tests were performed to confirm normal hearing. The generated iPSC lines expressed pluripotency gene
Externí odkaz:
https://doaj.org/article/85537c87e3934ece81c6e1596a1845c1
Publikováno v:
Neural Development, Vol 17, Iss 1, Pp 1-22 (2022)
Abstract Background Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-spec
Externí odkaz:
https://doaj.org/article/69ef13afcc0d451e9db232bcc699315d
Publikováno v:
Journal of International Advanced Otology, Vol 18, Iss 1, Pp 88-91 (2022)
Externí odkaz:
https://doaj.org/article/bf8579c4afc44d0eb6d3b84145e96481
Autor:
Chika Saegusa, Makoto Hosoya, Takanori Nishiyama, Tsubasa Saeki, Chisato Fujimoto, Hideyuki Okano, Masato Fujioka, Kaoru Ogawa
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 5, Iss 3, Pp 520-528 (2020)
Abstract Objectives Autophagy is an intracellular housekeeping process that degrades cytoplasmic organelles, damaged molecules, and abnormal proteins or pathogens and is essential for normal hearing. Recent studies revealed the essential roles of aut
Externí odkaz:
https://doaj.org/article/b0b14eb619b74994b8b53c58d9b7be82