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pro vyhledávání: '"Masato Akahira"'
Autor:
Yu Omori, Mayumi Nakajima, Kazumi Nishimura, Eiki Takahashi, Tadamasa Arai, Masato Akahira, Tomohiko Suzuki, Mie Kainoh
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 377-381 (2015)
This study was conducted to identify the characteristic pharmacological features of GT-0198 that is phenoxymethylbenzamide derivatives. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not
Externí odkaz:
https://doaj.org/article/1bc620297cbd42aa9b0cddf2defca93d
Autor:
Masato Akahira, Tomohiko Suzuki, Tadamasa Arai, Mayumi Nakajima, Yu Omori, Eiki Takahashi, Mie Kainoh, Kazumi Nishimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 377-381 (2015)
This study was conducted to identify the characteristic pharmacological features of GT-0198 that is phenoxymethylbenzamide derivatives. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not
Autor:
Masato Akahira, Tadamasa Arai, Eiki Takahashi, Hiroki Kumagai, Kazumi Nishimura, Mayumi Nakajima, Yu Omori, Tomohiko Suzuki, Ryoji Hayashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4603-4606
We describe the discovery of phenoxymethylbenzamide derivatives as a novel class of glycine transporter type-2 (GlyT-2) inhibitors. We found hit compound 1 (human GlyT-2, IC50 = 4040 nM) in our library and converted its 1-(1-(naphthalen-2-ylmethyl)pi