Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Masato, Shingyoji"'
Autor:
Hideki Terai, MD, Kenzo Soejima, MD, Asanao Shimokawa, PhD, Hidehito Horinouchi, MD, Junichi Shimizu, MD, Tetsunari Hase, MD, Ryota Kanemaru, MD, Kana Watanabe, MD, Kiichiro Ninomiya, MD, Naoko Aragane, MD, Noriko Yanagitani, MD, Yoshihiko Sakata, MD, Masahiro Seike, MD, Daichi Fujimoto, MD, Masashi Kasajima, MD, Akihito Kubo, MD, Sojiro Kusumoto, MD, Yoshitaka Oyamada, MD, Keiichi Fujiwara, MD, Masahide Mori, MD, Midori Hashimoto, MD, Masato Shingyoji, MD, Masahiro Kodani, MD, Jin Sakamoto, MD, Toshihiko Agatsuma, MD, Kosuke Kashiwabara, MD, Minehiko Inomata, MD, Motoko Tachihara, MD, Kazuhisa Tanaka, MD, Kenji Hayashihara, MD, Nobuyuki Koyama, MD, Kaoru Matsui, MD, Koichi Minato, MD, Daisuke Jingu, MD, Hiroyuki Sakashita, MD, Satoshi Hara, MD, Tomoyuki Naito, MD, Asuka Okada, MD, Masayuki Tanahashi, MD, Yuki Sato, MD, Koichiro Asano, MD, Takayuki Takeda, MD, Kensuke Nakazawa, MD, Toshiyuki Harada, MD, Kazuhiko Shibata, MD, Tatsuo Kato, MD, Etsuo Miyaoka, PhD, Ichiro Yoshino, MD, Akihiko Gemma, MD, Tetsuya Mitsudomi, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 11, Pp 100404- (2022)
Introduction: Pembrolizumab is a programmed death-ligand 1 inhibitor that was initially indicated for monotherapy in patients with advanced lung cancer. The Japanese Lung Cancer Society conducted an observational study on pembrolizumab using confirma
Externí odkaz:
https://doaj.org/article/67a827674fcd4c4087dafceff77375be
Autor:
Thao Thi Thanh Nguyen, Masato Shingyoji, Michiko Hanazono, Boya Zhong, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Abstract A majority of mesothelioma specimens were defective of p14 and p16 expression due to deletion of the INK4A/ARF region, and the p53 pathway was consequently inactivated by elevated MDM2 functions which facilitated p53 degradaton. We investiga
Externí odkaz:
https://doaj.org/article/a33b3973c63c4e3da9ba0af8d938437e
Autor:
Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi, Masatoshi Tagawa
Publikováno v:
Molecular Oncology, Vol 13, Iss 6, Pp 1419-1432 (2019)
Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in
Externí odkaz:
https://doaj.org/article/455ab0add9c64db28e0ba6554b010481
Autor:
Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi, Masatoshi Tagawa
Publikováno v:
Cancer Cell International, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated activities of several
Externí odkaz:
https://doaj.org/article/ad934b0dab264311b72721325c553d40
Autor:
Takao Morinaga, Thảo Thi Thanh Nguyễn, Boya Zhong, Michiko Hanazono, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-10 (2017)
Abstract Background Genetically modified adenoviruses (Ad) with preferential replications in tumor cells have been examined for a possible clinical applicability as an anti-cancer agent. A simple method to detect viral and cellular proteins is valuab
Externí odkaz:
https://doaj.org/article/174d5b8dd5d84b5091fb4d01f2ff172a
Autor:
Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting. Methods We co
Externí odkaz:
https://doaj.org/article/bfb496541896457c988a95250ffdedba
Autor:
Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi, Masatoshi Tagawa
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an in
Externí odkaz:
https://doaj.org/article/1792f90d5cf643a889404e840be146bc
Publikováno v:
Case Reports in Oncological Medicine, Vol 2019 (2019)
The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown. We herein report the case of a woman with squamous cell lung cancer who was a lon
Externí odkaz:
https://doaj.org/article/63e7ebc8a8584988abca8d24a37101d2
Autor:
Takahiro Nakajima, Haruhisa Saito, Jiro Terada, Yuki Ito, Masato Shingyoji, Tsukasa Ishiwata, Ichiro Yoshino, Hironori Ashinuma, Yuki Sata, Gaku Yamaguchi, Ayumu Otsuki, Shunichiro Iwasawa, Tomohiko Iida, Taiki Fujiwara, Chimori Konaka, Fuminobu Kuroda, Masafumi Misawa
Publikováno v:
Haigan. 61:100-108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf123126acf8c21de72a179c313cb3c
https://doi.org/10.2482/haigan.61.100
https://doi.org/10.2482/haigan.61.100
Autor:
Masato Shingyoji, Thi Thanh Nguyễn, Masatoshi Tagawa, Hideaki Shimada, Takao Morinaga, Michiko Hanazono, Kenzo Hiroshima, Yuji Tada, Boya Zhong
Publikováno v:
Apoptosis. 25:535-547
A majority of mesothelioma had the wild-type p53 genotype but was defective of p53 functions primarily due to a genetic defect in INK4A/ARF region. We examined a growth suppressive activity of CP-31398 which was developed to restore the p53 functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebace65ce5275639129a0ee0d1ab465c
https://doi.org/10.1007/s10495-020-01612-6
https://doi.org/10.1007/s10495-020-01612-6