Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Masateru Yamada"'
Autor:
Yasukatsu Izumi, Yasuhiro Izumiya, Masayuki Shiota, Tokihito Yukimura, Satoshi Shiojima, Masateru Yamada, Tadashi Kadowaki, Susumu Katsuma, Akira Hirasawa, Gozoh Tsujimoto, Hiroshi Iwao
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 1, Pp 91-94 (2004)
We analyzed gene expression in rat anti-Thy1 antibody-induced glomerulonephritis by using the cDNA microarray method. Ninety-seven genes that differed by more than 1.5-fold intensity in comparison with the controls were selected. Cluster analysis sho
Externí odkaz:
https://doaj.org/article/6edf9b9d08ed44e0a24a9d45676dae25
Autor:
Hiroaki Ohno, Zengye Hou, Junfeng Shi, Yamato Suzuki, Yohei Miyamoto, Masateru Yamada, Gozoh Tsujimoto, Nobuhiro Fuchi, Ying Xiao, Keiyu Oshida, Misato Yasue, Yoshinori Takei, Akira Hirasawa, Ning Liu
Publikováno v:
Biological & Pharmaceutical Bulletin. 38:1345-1351
Protein kinase CK2 ("casein kinase II") is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we have identified that one catalytic isozyme of CK2, C
Autor:
Mai Yagi, Yasuhito Nakadera, Eriko Higashi, Yuko Kato, Ayano Watanabe, Hideo Kigoshi, Masateru Yamada, Yutaka Nishimura, Nobuhiro Fuchi, Takumi Aoki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:565-570
We identified 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted ureas as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating chronic kidney diseases. Compound 19 exhibited excellent sEH inhibitory activ
Autor:
Yoshitaka Yoshizawa, Mie Kaino, Masateru Yamada, Takumi Aoki, Hidenori Mochizuki, Rieko Shimozono, Yoshiji Asaoka, Hidetoshi Noda
Publikováno v:
Molecular Pharmacology. 84:62-70
Oxidative stress is considered to be a key mechanism of hepatocellular injury and disease progression in patients with nonalcoholic steatohepatitis (NASH). The transcription factor Nrf2 (nuclear factor-erythroid-2-related factor 2) plays a central ro
Autor:
Shinichi Yamaguchi, Kazuharu Suyama, Kazumi Nishimura, Hiroshi Ueda, Yosuke Iura, Masateru Yamada, Toshiya Takahashi, Shigeo Fujii, Nobuhiro Fuchi, Aiko Nitta, Hiroaki Kaneko, Yumiko Sekiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4358-4361
We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was identified, and derivatives were prepared to develop potent inhibitory activity. As a res
Autor:
Masateru Yamada, Mitsutaka Tamura, Satoshi Shiojima, Akira Hirasawa, Yohei Miyamoto, Tadashi Kadowaki, Tetsuya Adachi, Yumiko Sekiya, Gozoh Tsujimoto, Yasushi Okuno, Wako Yumura, Shigeo Fujii, Susumu Katsuma, Taka-aki Koshimizu, Makio Kobayashi, Hiroshi Nihei
Publikováno v:
Proceedings of the National Academy of Sciences. 102:7736-7741
Glomerulonephritis (GN) is a progressive inflammation that may be caused by a variety of underlying disorders. It is the primary cause of chronic renal failure and end-stage renal disease, which require dialysis and transplantation worldwide. Immunos
Autor:
Tetsuya Adachi, Takeo Awaji, Akira Hirasawa, Susumu Katsuma, Gozoh Tsujimoto, Shunichi Miyazaki, Keiko Tsumaya, Yukihiko Sugimoto, Masateru Yamada
Publikováno v:
Nature Medicine. 11:90-94
Diabetes, a disease in which the body does not produce or use insulin properly, is a serious global health problem. Gut polypeptides secreted in response to food intake, such as glucagon-like peptide-1 (GLP-1), are potent incretin hormones that enhan
Autor:
Kuk Hyun Shin, Yeon Sil Lee, Kazuo Ohuchi, Masateru Yamada, Sang-Hyun Lee, Bak-Kwang Kim, Sang Hoon Jung
Publikováno v:
Archives of Pharmacal Research. 27:628-632
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E2 (PGE2) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetra
Autor:
Susumu Katsuma, Seiichi Suzuki, Xiao-Kang Li, Torayuki Okuyama, Akira Hirasawa, Satoshi Shiojima, Gozoh Tsujimoto, Naoko Funeshima, Masateru Yamada, Yasuyuki Fukuhara, Masayuki Fujino, Mikiko Kawasaki
Publikováno v:
Journal of Hepatology. 38:784-792
Background/Aims : When a loss of hepatic mass occurs, the expression of a large number of genes is either induced or altered, accompanying hepatocyte proliferation. In the present study, we made an in-house cDNA microarray containing 4608 elements (L
Autor:
Hajimu Kurumatani, Masateru Yamada, Motohiro Suzuki, Mitsutaka Tamura, Rie Sasaki, Nahoko Sato, Teruo Matsushita
Publikováno v:
European Journal of Pharmacology. 449:167-176
Effects of beraprost sodium, a chemically stable prostacyclin analogue, on renal dysfunction in an experimental rat model of glomerulonephritis were investigated. Beraprost sodium (30, 100 and 300 μg/kg) was orally given twice daily from the late st