Výsledky vyhledávání - "Masateru Kohno"

Valsartan Restores Sarcoplasmic Reticulum Function With No Appreciable Effect on Resting Cardiac Function in Pacing-Induced Heart Failure

Autor: Masateru Kohno, Takahiro Tokuhisa, Masahiro Doi, Takeshi Yamamoto, Masafumi Yano, Shigeki Kobayashi, Shinichi Okuda, Masunori Matsuzaki, Tomoko Ohkusa, Tetsuro Oda

Publikováno v: Circulation. 109:911-919

Background— Although angiotensin II receptor blockade is considered to be useful for the treatment of human heart failure, little beneficial hemodynamic effect has been shown in some experimental failing hearts. In this study, we assessed the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a29014ca23f4e5184d4586b093cfcc
https://doi.org/10.1161/01.cir.0000115526.92541.d2

Zobrazit plný text záznamu

A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

Autor: Masahiro Doi, Masafumi Yano, Shinichi Okuda, Masunori Matsuzaki, Takahiro Tokuhisa, Michihiro Kohno, Tetsuro Oda, Masateru Kohno, Tomoko Ohkusa, Shigeki Kobayashi

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 284:H1035-H1042

Defective interaction between FKBP12.6 and ryanodine receptors (RyR) is a possible cause of cardiac dysfunction in heart failure (HF). Here, we assess whether the new cardioprotective agent JTV519 can correct it in tachycardia-induced HF. HF was indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b44645a13583ed1971207cbf4e6693
https://doi.org/10.1152/ajpheart.00722.2002

Zobrazit plný text záznamu

Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure

Autor: Masateru Kohno, Masunori Matsuzaki, Shigeki Kobayashi, Michihiro Kohno, Jyutaro Yamada, Kaoru Ono, Masae Suetsugu, Tomoko Ohkusa, Masafumi Yano, Takayuki Hisaoka

Publikováno v: Cardiovascular Research. 49:319-329

Objective: The Rho/Rho-kinase system regulates Ca2+ sensitivity in vascular smooth muscle. A new drug, Y-27632, specifically inhibits Rho-kinase and hence decreases the phosphorylation of myosin light chain, thus reducing contraction. Here, we compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e77315a4cb0393cf7f555666a1beaa
https://doi.org/10.1016/s0008-6363(00)00279-0

Zobrazit plný text záznamu

Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca2+ release in heart failure

Autor: Masunori Matsuzaki, Masateru Kohno, Shigeki Kobayashi, Masafumi Yano, Kaoru Ono, Michihuro Kohno, Taketo Tanigawa, Tomoko Ohkusa, Takayuki Hisaoka

Publikováno v: Cardiovascular Research. 48:323-331

Objective: Little information is available as to the Ca2+ release function of the sarcoplasmic reticulum (SR) in heart failure. We assessed whether the alteration in this function in heart failure is related to a change in the role of FK binding prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca5ee55d6fb5f9dfb8f588d8d6620c0
https://doi.org/10.1016/s0008-6363(00)00191-7

Zobrazit plný text záznamu

Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca 2+ Leak Through Ryanodine Receptor in Heart Failure

Autor: Hiroshi Okamoto, Naoya Noguchi, Michihiro Kohno, Masateru Kohno, Takeshi Yamamoto, Masafumi Yano, Tomoko Ohkusa, Masae Suetsugu, Takayuki Hisaoka, Yuji Hisamatsu, Kaoru Ono, Masunori Matsuzaki, Shigeki Kobayashi, Shin Takasawa

Publikováno v: Circulation. 102:2131-2136

Background —In the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase is believed to be a major determinant. Here, we report a novel mechanism of cardiac dysfunction rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cca5f5ede11067e89097c4199e0e22
https://doi.org/10.1161/01.cir.102.17.2131

Zobrazit plný text záznamu

Impact of the cross-sectional geometry of the post-deployment coronary stent on in-stent neointimal hyperplasia: an intravascular ultrasound study

Autor: Takashige, Murata, Takafumi, Hiro, Takashi, Fujii, Kyounori, Yasumoto, Akihiro, Murashige, Masateru, Kohno, Jyutaro, Yamada, Toshiro, Miura, Masunori, Matsuzaki

Publikováno v: Circulation journal : official journal of the Japanese Circulation Society. 66(5)

To establish the relationship between the cross-sectional geometry of the post-deployment stent and the degree of in-stent neointimal hyperplasia (INH), intravascular ultrasound (IVUS) was used to examine cross-sections of the coronary arteries from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22ac74fb74b8b2e712702bf8f0c6dd37
https://pubmed.ncbi.nlm.nih.gov/12030346

Zobrazit plný text záznamu

Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor

Autor: Shigeki Kobayashi, Masateru Kohno, Masae Suetsugu, Shinichi Okuda, Michihiro Kohno, Takahiro Tokuhisa, Masahiro Doi, Masunori Matsuzaki, Yuhji Hisamatsu, Tomoko Ohkusa, Masafumi Yano

Publikováno v: Circulation. 105(11)

Background — In heart failure, protein kinase A-mediated hyperphosphorylation of ryanodine receptors (RyRs) in sarcoplasmic reticulum (SR) causes dissociation of FKBP12.6 from RyRs. This results in an abnormal Ca 2+ leak through RyRs, possibly lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98517b9d86d4567cc409c936df737029
https://pubmed.ncbi.nlm.nih.gov/11901051

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání