Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Masataka Michigami"'
Autor:
Hiroya Shiba, Tomoka Hirose, Yunshen Fu, Masataka Michigami, Ikuo Fujii, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 888 (2023)
T cells play important roles in various immune reactions, and their activation is necessary for cancer immunotherapy. Previously, we showed that polyamidoamine (PAMAM) dendrimers modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine
Externí odkaz:
https://doaj.org/article/15571b38718d4c8bbdbfdd711fdcd37f
Autor:
Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247045 (2021)
As a new alternative to antibody-drug conjugates, we generated "ligand-targeting" peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery. The PDC makes a complex with an extracellular liga
Externí odkaz:
https://doaj.org/article/b2403cc28ebb44e4a4363fa6b0559cec
Autor:
Masataka Michigami, Tharanga M. R. Ramanayake Mudiyanselage, Miho Suzuki, Hirotsugu Ishizako, Kunpei Notsu, Kikuya Sugiura, Ikuo Fujii
Publikováno v:
ACS Chemical Biology. 17:647-653
As a small affinity molecule to serve as an alternative to antibodies, we have developed a conformationally constrained peptide with a de novo designed helix-loop-helix (HLH) scaffold. To evaluate its potential for biomedical applications, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a58d4bea81688f71fbb748df821344
https://doi.org/10.1021/acschembio.1c00940
https://doi.org/10.1021/acschembio.1c00940
Autor:
Hiroya Shiba, Misaki Nishio, Mei Sawada, Mamiko Tamaki, Masataka Michigami, Shinya Nakai, Ikuhiko Nakase, Ikuo Fujii, Akikazu Matsumoto, Chie Kojima
Publikováno v:
Journal of Materials Chemistry B. 10:2463-2470
Although T cells play important roles in various immune reactions, there are only a few reports on delivery systems into T cells. Our previous study showed that carboxy-terminal phenylalanine (Phe)-modified polyamidoamine (PAMAM) dendrimers have both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8abaecbdf1b38892000b8267d2521ae
https://doi.org/10.1039/d1tb01980e
https://doi.org/10.1039/d1tb01980e
Autor:
Tharanga MR RAMANAYAKE MUDIYANSELAGE, Daisuke FUJIWARA, Masataka MICHIGAMI, Shunichi WATANABE, Zhengmao YE, Atsuko UEDA, Ryoji KANEGI, Shingo HATOYA, Ikuo FUJII, Kikuya SUGIURA
Publikováno v:
The Journal of veterinary medical science. 84(8)
Blocking the interaction between CD28 and B7 by cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a potent immune checkpoint that prevents damage to host tissues from excessive immune responses. However, it also significantly diminishes immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28569d2f405bb7a5f744b130a7f14246
https://pubmed.ncbi.nlm.nih.gov/35753760
https://pubmed.ncbi.nlm.nih.gov/35753760
Autor:
Yuto Nakatani, Zhengmao Ye, Yuki Ishizue, Taishi Higashi, Teruko Imai, Ikuo Fujii, Masataka Michigami
Publikováno v:
Molecular pharmaceutics. 19(7)
The effectiveness of protein and peptide pharmaceuticals depends essentially on their intrinsic pharmacokinetics. Small-sized pharmaceuticals in particular often suffer from short serum half-lives due to rapid renal clearance. To improve the pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99616b43651354baf920a2b4236d9e7
https://pubmed.ncbi.nlm.nih.gov/35635006
https://pubmed.ncbi.nlm.nih.gov/35635006
Publikováno v:
Drug Delivery System. 35:212-221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6c0958cd14e1a0ccf60184e3c04740
https://doi.org/10.2745/dds.35.212
https://doi.org/10.2745/dds.35.212
Autor:
Masataka Michigami, Atsuko Uyeda, Ikuo Fujii, Tharanga M R Ramanayake Mudiyanselage, Zhengmao Ye, Kikuya Sugiura, Norimitsu Inoue, Daisuke Fujiwara
Publikováno v:
ACS Chemical Biology. 15:360-368
Molecular-targeting peptides and mini-proteins are promising alternatives to antibodies in a wide range of applications in bioscience and medicine. We have developed a helix-loop-helix (HLH) peptide as an alternative to antibodies to inhibit specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59b72fdefe5844f5199f7d5e9b6872e
https://doi.org/10.1021/acschembio.9b00743
https://doi.org/10.1021/acschembio.9b00743
Autor:
RAMANAYAKE MUDIYANSELAGE, Tharanga M. R., Daisuke FUJIWARA, Masataka MICHIGAMI, Shunichi WATANABE, Zhengmao YE, Atsuko UEDA, Ryoji KANEGI, Shingo HATOYA, Ikuo FUJII, Kikuya SUGIURA
Publikováno v:
Journal of Veterinary Medical Science; 2022, Vol. 84 Issue 8, p1101-1107, 7p
Autor:
Seiji Kodama, Ikuo Fujii, Masahiro Oguri, Toshio Nishihara, Ikuhiko Nakase, Kenji Kono, Sihyun Ham, Eiji Yuba, Haeri Im, Jong Young Joung, Sunhee Cho, Daisuke Fujiwara, Hidekazu Kitada, Kazunori Shiraishi, Masataka Michigami
Publikováno v:
Angewandte Chemie International Edition. 55:10612-10615
The design of inhibitors of intracellular protein-protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized helix-loop-helix (cHLH) peptide as a scaffold for generating cell-permeable PPI inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22550ca301d3a6b22a8dedb8ab765d
https://doi.org/10.1002/anie.201603230
https://doi.org/10.1002/anie.201603230