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Autor:
Nicole Staudt, Christof Niehrs, Ya Lin Huang, Masasumi Tada, Olga Kazanskaya, Reiner Ahrendt, Corinne Houart, Luca Caneparo
Publikováno v:
Genesdevelopment. 21(4)
Dickkopf-1 (Dkk1) is a secreted protein that negatively modulates the Wnt/βcatenin pathway. Lack of Dkk1 function affects head formation in frog and mice, supporting the idea that Dkk1 acts as a “head inducer” during gastrulation. We show here t