Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Masashi Toyofuku"'
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits m
Externí odkaz:
https://doaj.org/article/0d63b239f564462aba95ccd87d503257
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
Autor:
Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito
Publikováno v:
European journal of medicinal chemistry. 239
Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1799e4688154809d1d4f50bf466e86b
https://pubmed.ncbi.nlm.nih.gov/35749987
https://pubmed.ncbi.nlm.nih.gov/35749987
Autor:
Noriko Suzuki, Yasukazu Tajima, Akiyoshi Kunugi, Motohisa Suzuki, Atsushi Suzuki, Satoshi Sogabe, Yasuyuki Awasaki, Tomohiro Kaku, Masashi Toyofuku, Haruhiko Kuno, Haruhide Kimura, Yohei Kosugi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae405eef47a2a7690b8ffdb47e5838ee
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
Autor:
Shigeru Igaki, Ryosuke Hibino, Ken Tsuchida, Shinji Iwasaki, Satoru Matsuda, Ryujiro Hara, Hiroko Kamada, Masashi Toyofuku, Haruhide Kimura, Misa Iwatani, Rina Baba, Mitsuhiro Ito, Kota Matsumiya, Hideyuki Oki, Yusuke Kamada, Takeshi Hirakawa, Shinji Morimoto
Publikováno v:
Neuropsychopharmacology
Dysregulation of histone H3 lysine 4 (H3K4) methylation has been implicated in the pathogenesis of several neurodevelopmental disorders. Targeting lysine-specific demethylase 1 (LSD1), an H3K4 demethylase, is therefore a promising approach to treat t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a412d79e9c823a65878035790b06f0
https://doi.org/10.1038/s41386-018-0300-9
https://doi.org/10.1038/s41386-018-0300-9
Autor:
Masato Yoshikawa, Tomoya Sameshima, Yoshihiko Hirozane, Masashi Toyofuku, Yukiya Tanaka, Takatoshi Yogo, Ikuo Miyahisa
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(21)
Selectivity profiling of compounds is important for kinase drug discovery. To this end, we aimed to develop a broad-range protein kinase assay by synthesizing a novel staurosporine-derived fluorescent probe based on staurosporine and kinase-binding r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d536c2a4c430f25a08fda10592c04540
https://pubmed.ncbi.nlm.nih.gov/31526603
https://pubmed.ncbi.nlm.nih.gov/31526603
Publikováno v:
Pure and Applied Chemistry. 82:565-575
This account summarizes our recent results on transition-metal-catalyzed cleavage of C–Se bond and addition to unsaturated hydrocarbons such as alkynes and allenes. Pd(0)-catalyzed intramolecular carbamoselenation of alkynes forms four- to eight-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d59ad17f16d703f81fe9c5e1cbda16
https://doi.org/10.1351/pac-con-09-11-13
https://doi.org/10.1351/pac-con-09-11-13
Autor:
Masashi Toyofuku, Erika Murase, H. Nagai, Nobuaki Kambe, Tsutomu Shin-ike, Hitoshi Kuniyasu, Shin-ichi Fujiwara
Publikováno v:
European Journal of Organic Chemistry. 2009:3141-3144
Pd(PPh3)4-catalyzed intramolecular selenocarbamoylation of allenes led to the regioselective formation of α,β-unsaturated five- and six-membered lactams having an allyl selenide unit. This procedure could be applied to the synthesis of the correspo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70a185bf8a36375c49877ebd0dcf70a
https://doi.org/10.1002/ejoc.200900319
https://doi.org/10.1002/ejoc.200900319
Autor:
Yuji Imahori, Masashi Toyofuku, Tsutomu Shin-ike, Yoshihiko Shimizu, Nobuaki Kambe, Shin-ichi Fujiwara
Publikováno v:
Tetrahedron Letters. 50:3628-3630
A new synthetic method of α-alkylidene-β-lactam frameworks has been developed. Irradiation of carbamotelluroates 5 having a propargylic group at the nitrogen atom with visible light afforded α-telluromethylene-β-lactams 6 by 4- exo - dig cyclizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99d67aab3d3e96f5bbf6f006af3f214
https://doi.org/10.1016/j.tetlet.2009.03.071
https://doi.org/10.1016/j.tetlet.2009.03.071
Publikováno v:
ChemInform. 41
This account summarizes our recent results on transition-metal-catalyzed cleavage of C-Se bond and addition to unsaturated hydrocarbons such as alkynes and allenes. Pd(0)-catalyzed intramolecular carbamoselenation of alkynes forms four- to eight-memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd14f14ea8ba99e80381ef73d7880fe
https://doi.org/10.1002/chin.201035237
https://doi.org/10.1002/chin.201035237