Immortalized Hepatocytes Using Human Artificial Chromosome

Autor: Masahiro Ito M.D., Ph.D., Ryoutaro Ito, Daisuke Yoshihara, Masashi Ikeno, Megumi Kamiya, Nobutaka Suzuki, Akihiko Horiguchi, Hideo Nagata, Toshiyuki Yamamoto, Naoya Kobayashi, Ira J. Fox, Tsuneko Okazaki, Syuichi Miyakama

Publikováno v: Cell Transplantation, Vol 17 (2008)

The shortage of organ donors has impeded the development of human hepatocyte transplantation. Immortalized hepatocytes could provide an unlimited supply of transplantable cells. To determine whether immortalized hepatocytes could provide global metab

Externí odkaz: https://doaj.org/article/3dbdfbe9cdca47d19a71fed04e12f65c

Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth transduced with herpes simplex virus thymidine kinase

Autor: Makoto Horikawa, Shinichiro Koizumi, Oishi Tomoya, Taisuke Yamamoto, Masashi Ikeno, Masahiko Ito, Tomohiro Yamasaki, Shinji Amano, Tetsuro Sameshima, Hiroki Namba, Kazuhiko Kurozumi

Publikováno v: WFNOS 2022 Abstract Book.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cb7190f922e0acee326658089aa73cb
https://doi.org/10.14791/btrt.2022.10.f-2654

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Autor: A. Radu Aricescu, Yuki Morioka, Yuka Takeuchi, Tatsuya Shimada, Oleg Senkov, Rahul Kaushik, Kosei Takeuchi, Michisuke Yuzaki, Hiroyuki Sasakura, Stoyan Stoyanov, Alexander Dityatev, Maura Ferrer-Ferrer, Kunimichi Suzuki, Masashi Ikeno, Eriko Miura, Amber J. Clayton, Keiko Matsuda, Wataru Kakegawa, Veronica T. Chang, Masahiko Watanabe, Jonathan Elegheert, Inseon Song, Shintaro Otsuka

Publikováno v: Science
Science, American Association for the Advancement of Science, 2020, 369 (6507), ⟨10.1126/science.abb4853⟩
Science / Science now 369(6507), eabb4853-(2020). doi:10.1126/science.abb4853

Synthetic excitatory synaptic organizer The human brain contains trillions of synapses within a vast network of neurons. Synapse remodeling is essential to ensure the efficient reception and integration of external stimuli and to store and retrieve i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58f31123378c66772e0ce9e75f687ac
https://hal.archives-ouvertes.fr/hal-03396266

Applications of bottom-up human artificial chromosomes in cell research and cell engineering

Autor: Yoshinori Hasegawa, Masashi Ikeno

Publikováno v: Experimental cell research. 390(1)

Chromosome manipulation is a useful technique in biological science. We have constructed human artificial chromosomes (HACs) based on the transfection of centromeric alphoid DNA precursors into cultured human cells. Moreover, HAC-based technology has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93d9bdfcd5038d90ecc4229a4c37484
https://pubmed.ncbi.nlm.nih.gov/31874174

Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs

Autor: Hiroshi Masumoto, Tomoyuki Ishikura, Takashi Watanabe, Osamu Ohara, Haruhiko Koseki, Yoshiaki Okamura, Junpei Suzuki, Yoshinori Hasegawa, Tuneko Okazaki, Takanori Hasegawa, Masashi Ikeno, Manabu Nakayama

Publikováno v: Chromosoma

The human artificial chromosome (HAC) vector is a promising tool to improve the problematic suppression and position effects of transgene expression frequently seen in transgenic cells and animals produced by conventional plasmid or viral vectors. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fbb02d47de0bfa9f677008e1bd9d03
https://doi.org/10.1007/s00412-014-0488-3