Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Masashi Demura"'
Autor:
Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Shin-ichi Horike, Makiko Meguro-Horike, Takashi Yoneda, Yoshiyu Takeda
Publikováno v:
Endocrine Journal, Vol 71, Iss 3, Pp 245-252 (2023)
11Beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) is a key enzyme involved in metabolic syndrome. Transcript-specific epigenetic regulation of the gene encoding 11β-HSD1 (HSD11B1) has been reported. We examined the mRNA level and methylation status
Externí odkaz:
https://doaj.org/article/aa90d9ea9cab47639b012db82d0472fd
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8099 (2024)
Activation of the renin–angiotensin–aldosterone system (RAAS) plays an important pathophysiological role in hypertension. Increased mRNA levels of the angiotensinogen angiotensin-converting enzyme, angiotensin type 1 receptor gene, Agtr1a, and th
Externí odkaz:
https://doaj.org/article/a820896862eb4968823062d6b2adaabb
Autor:
Yuna Miyajima, Shigehiro Karashima, Kazuhiro Ogai, Kouki Taniguchi, Kohei Ogura, Masaki Kawakami, Hidetaka Nambo, Mitsuhiro Kometani, Daisuke Aono, Masashi Demura, Takashi Yoneda, Hiromasa Tsujiguchi, Akinori Hara, Hiroyuki Nakamura, Shigefumi Okamoto
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate t
Externí odkaz:
https://doaj.org/article/fb7ece4e8cfa48fbb3cb8c8474614cfa
Autor:
Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Takashi Yoneda, Yoshiyu Takeda
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5782 (2023)
Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene
Externí odkaz:
https://doaj.org/article/cfcdbc179cc3433da96d703a873286af
Autor:
Toshitaka Sawamura, Shigehiro Karashima, Satoshi Nagase, Hidetaka Nambo, Eiko Shimizu, Takuya Higashitani, Daisuke Aono, Azusa Ohbatake, Mitsuhiro Kometani, Masashi Demura, Kenji Furukawa, Yoshiyu Takeda, Takashi Yoneda
Publikováno v:
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Plasma aldosterone-to-renin ratio (ARR) is popularly used for screening primary aldosteronism (PA). Some medications, including diuretics, are known to have an effect on ARR and cause false-negative and false-positive results in P
Externí odkaz:
https://doaj.org/article/9a36327561d04eac83323f10dc0b544d
Autor:
Takuya Higashitani, Shigehiro Karashima, Daisuke Aono, Seigoh Konishi, Mitsuhiro Kometani, Rie Oka, Masashi Demura, Kenji Furukawa, Yuto Yamazaki, Hironobu Sasano, Takashi Yoneda, Yoshiyu Takeda
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-6 (2020)
Renovascular hypertension (RVHT) is an important and potentially treatable form of resistant hypertension. Hypercortisolemia could also cause hypertension and diabetes mellitus. We experienced a case wherein adrenalectomy markedly improved blood pres
Externí odkaz:
https://doaj.org/article/82e13783e66b47c5bce59383c27f1f3e
Autor:
Satoshi Nagase, Shigehiro Karashima, Hiromasa Tsujiguchi, Hirohito Tsuboi, Sakae Miyagi, Mitsuhiro Kometani, Daisuke Aono, Takuya Higashitani, Masashi Demura, Hiroyuki Sakakibara, Akihiro Yoshida, Akinori Hara, Hiroyuki Nakamura, Yoshiyu Takeda, Hidetaka Nambo, Takashi Yoneda, Shigefumi Okamoto
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Salt intake is one of the most important environmental factors impacting hypertension onset. Meanwhile, the potential roles of the gut microbiome (GM) in altering the health status of hosts have drawn considerable attention. Here, we aimed to perform
Externí odkaz:
https://doaj.org/article/586f3f1a2f31402a8b9038c8d9ac8922
Autor:
Yoko Ota, Natalia Korshunova, Masashi Demura, Midori Katsuyama, Hironobu Katsuyama, Sri Ratna Rahayu, Kiyofumi Saijoh
Publikováno v:
Environmental Health and Preventive Medicine, Vol 22, Iss 1, Pp 1-8 (2017)
Abstract Background A man-made chemical disaster occurred in the Amur River, leading to posttraumatic stress disorder (PTSD) in the Nanai people indigenous to the river’s surrounding area. PTSD severity measured by the total scores of Impact of Eve
Externí odkaz:
https://doaj.org/article/371114d95cf84538b5a1390519aa0712
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4587 (2021)
Angiotensinogen (AGT) and aldosterone play key roles in the regulation of blood pressure and are implicated in the pathogenesis of cardiovascular diseases. DNA methylation typically acts to repress gene transcription. The aldosterone synthase gene CY
Externí odkaz:
https://doaj.org/article/5517e19c77cd487a98ad1ddec5b66757
Autor:
Yoshimichi Takeda, Masashi Demura, Fen Wang, Shigehiro Karashima, Takashi Yoneda, Mitsuhiro Kometani, Atsushi Hashimoto, Daisuke Aono, Shin‐ichi Horike, Makiko Meguro‐Horike, Masakazu Yamagishi, Yoshiyu Takeda
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
BackgroundDNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We demonstrate that stimulatory signals can change the DNA methylation status around transc
Externí odkaz:
https://doaj.org/article/cafd199cef5c470fb67f4cd043f28428