Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Masashi, Mima"'
Autor:
Masanao Kyuuma, Ayaka Kaku, Chiemi Mishima-Tsumagari, Bunichiro Ogawa, Mayumi Endo, Yunoshin Tamura, Kei-ichiro Ishikura, Masashi Mima, Yutaka Nakanishi, Yasuyuki Fujii
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics have become an important component of treatment strategies for a variety of diseases, but the immunogenicity of large immune complexes (ICs) and aggregates of biologics may increase risk of adverse events is a concern for biologics and it r
Externí odkaz:
https://doaj.org/article/93e7dbb80a1a452d968da965f61623be
Autor:
Fumihito Ushiyama, Hideaki Amada, Tomoki Takeuchi, Nozomi Tanaka-Yamamoto, Harumi Kanazawa, Koichiro Nakano, Masashi Mima, Aiko Masuko, Iichiro Takata, Kosuke Hitaka, Kunihiko Iwamoto, Hiroyuki Sugiyama, Norikazu Ohtake
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
Externí odkaz:
https://doaj.org/article/17fa358e19ce435eaf8d3e740e6f6ab1
Autor:
Tomoki Takeuchi, Yusaku Nomura, Tomoko Tamita, Rie Nishikawa, Hiroyuki Kakinuma, Naoki Kojima, Kosuke Hitaka, Yunoshin Tamura, Masafumi Kamitani, Masashi Mima, Akiko Nozoe, Masato Hayashi
Publikováno v:
Journal of Medicinal Chemistry. 66:822-836
Matrix metalloproteinase-2 (MMP2) is a zinc-dependent endopeptidase and a promising target for various diseases, including cancer and fibrosis. Herein, we report the discovery of a novel MMP2-selective inhibitor with high chemical stability and slow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee2c823088d6fbc7258a75ecef0c88
https://doi.org/10.1021/acs.jmedchem.2c01698
https://doi.org/10.1021/acs.jmedchem.2c01698
Autor:
Tomoki Takeuchi, Masato Hayashi, Tomoko Tamita, Yusaku Nomura, Naoki Kojima, Akiko Mitani, Takuya Takeda, Kosuke Hitaka, Yuki Kato, Masafumi Kamitani, Masashi Mima, Hidetoh Toki, Masahiko Ohkubo, Akiko Nozoe, Hiroyuki Kakinuma
Publikováno v:
Journal of Medicinal Chemistry. 65:8493-8510
Matrix metalloproteinase-2 (MMP2) is a zinc-dependent endopeptidase that plays important roles in the degradation of extracellular matrix proteins. MMP2 is considered to be an attractive target for the treatment of various diseases such as cancer, ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56fb1ec00ef8793d1de48786c789f9e
https://doi.org/10.1021/acs.jmedchem.2c00613
https://doi.org/10.1021/acs.jmedchem.2c00613
Autor:
Aiko Masuko, Hiroyuki Sugiyama, Fumihito Ushiyama, Harumi Kanazawa, Koichiro Nakano, Norikazu Ohtake, Masashi Mima, Kosuke Hitaka, Hideaki Amada, Takeuchi Tomoki, Nozomi Tanaka-Yamamoto, Kunihiko Iwamoto, Iichiro Takata
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
DNA gyrase and topoisomerase IV are well-validated pharmacological targets, and quinolone antibacterial drugs are marketed as their representative inhibitors. However, in recent years, resistance to these existing drugs has become a problem, and new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ab8f6fd6bd3f2be8c5a152b9adb049
https://doi.org/10.1021/acsomega.0c00865
https://doi.org/10.1021/acsomega.0c00865
Autor:
Yudai, Imai, Daisuke, Wakasugi, Ryo, Suzuki, Sota, Kato, Mami, Sugisaki, Masashi, Mima, Hiroh, Miyagawa, Mayumi, Endo, Natsuko, Fujimoto, Takuya, Fukunaga, Sayaka, Kato, Shoichi, Kuroda, Teisuke, Takahashi, Hiroyuki, Kakinuma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 79:129050
Heparanase-1 (HPSE1) is an endo-β-d-glucuronidase that cleaves heparan sulfate proteoglycans into short-chain heparan sulfates (HS). The inhibition of HPSE1 has therapeutic potential for proteinuric diseases such as nephrotic syndrome because increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1989640235cab9d4f57fea5d757fd63
https://doi.org/10.1016/j.bmcl.2022.129050
https://doi.org/10.1016/j.bmcl.2022.129050
Autor:
Yuya Ogata, Harumi Kanazawa, Macias Alba, Norikazu Ohtake, Allan E. Surgenor, Iichiro Takata, Hajime Takashima, Walmsley David, Kiyoko Fujita, Hayley Angove, Kunihiko Iwamoto, Masashi Mima, Hiroyuki Sugiyama, Fumihito Ushiyama, Junya Yamagishi, Yousuke Yamada, Alan P. Robertson, Kosuke Hitaka, Koichiro Nakano, Hayato Watanabe, Atsushi Okada, Yohei Matsuda, Roderick E. Hubbard, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Risa Kurimoto-Tsuruta, Lisa Baker, Akihiro Tanaka, R. Harris
Publikováno v:
Journal of medicinal chemistry. 63(23)
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-negative bacteria. The most advanced, disclosed Lp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019ee8a95fea26f38a355f0054fb803d
https://pubmed.ncbi.nlm.nih.gov/33210531
https://pubmed.ncbi.nlm.nih.gov/33210531
Autor:
Yuya Ogata, Nozomi Tanaka-Yamamoto, Naoki Sasamoto, Iichiro Takata, Katsumasa Otake, Hajime Takashima, Yohei Matsuda, Haruhiro Yamashita, Mayumi Endo, Kiyoko Fujita, Kaori Ueki, Masashi Mima, Satoshi Tsuji, Hirotoshi Okumura, Hiroyuki Sugiyama, Fumihito Ushiyama, Risa Kurimoto-Tsuruta
Publikováno v:
Bioorganicmedicinal chemistry. 30
Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5917a1ea67529b22ac1ee7b5021a36ec
https://pubmed.ncbi.nlm.nih.gov/33385955
https://pubmed.ncbi.nlm.nih.gov/33385955
Autor:
Mayumi Endo, Hideaki Amada, Masafumi Kamitani, Takeuchi Tomoki, Norikazu Ohtake, Yunoshin Tamura, Aiko Masuko, Nozomi Tanaka-Yamamoto, Hiroyuki Sugiyama, Fumihito Ushiyama, Yasuhiro Mihara, Kosuke Hitaka, Iichiro Takata, Reiko Wada, Masashi Mima
Publikováno v:
Bioorganicmedicinal chemistry. 28(22)
The global increase in multidrug-resistant pathogens has caused severe problems in the treatment of infections. To overcome these difficulties, the advent of a new chemical class of antibacterial drug is eagerly desired. We aimed at creating novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c778902e9c7dd887132f2d7e97ce1d0
https://pubmed.ncbi.nlm.nih.gov/33032189
https://pubmed.ncbi.nlm.nih.gov/33032189
Autor:
Kumsun Paku, Hiroyoshi Matsumura, Yusuke Mori, Tomoya Kitatani, Koji Tomoo, Tsuyoshi Inoue, Hiroaki Adachi, Satoshi Murakami, Shigeru Sugiyama, Masashi Mima, Syou Maki, Takahiro Iwamoto, Satomi Kita, Toshimasa Ishida, Hiroshi Yoshikawa, Chika Kawai, Kazufumi Takano
Publikováno v:
Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(No. Pt 12):1125-7
The plasma-membrane Na(+)/Ca(2+) exchanger (NCX) regulates intracellular Ca(2+) levels in cardiac myocytes. Two Ca(2+)-binding domains (CBD1 and CBD2) exist in the large cytosolic loop of NCX. The binding of Ca(2+) to CBD1 results in conformational c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645a7e55d27bd3c7f52c77ef7844b456
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100713093
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100713093