Pten dose dictates cancer progression in the prostate.

Autor: Lloyd C Trotman, Masaru Niki, Zohar A Dotan, Jason A Koutcher, Antonio Di Cristofano, Andrew Xiao, Alan S Khoo, Pradip Roy-Burman, Norman M Greenberg, Terry Van Dyke, Carlos Cordon-Cardo, Pier Paolo Pandolfi

Publikováno v: PLoS Biology, Vol 1, Iss 3, p E59 (2003)

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PT

Externí odkaz: https://doaj.org/article/587d4e0ca2bb4667b766fc985dd850f7

Identification of DOK genes as lung tumor suppressors

Autor: Janos Szoke, Marc Ladanyi, Agnes Viale, Masaru Niki, Alice H. Berger, William L. Gerald, Nicholas D. Socci, Cameron Brennan, Noriko Motoi, Julie Teruya-Feldstein, Barry S. Taylor, Pier Paolo Pandolfi, Alessandro Morotti, Paul B. Rothman

Publikováno v: Nature Genetics. 42:216-223

Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci remain to be determined. Here we identify the dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a524193f936b10f249d251d788a7310
https://doi.org/10.1038/ng.527

Role of Dok-1 and Dok-2 in Leukemia Suppression

Autor: Mingming Zhao, Pier Paolo Pandolfi, Antonio Di Cristofano, Linda Van Aelst, Carlos Cordon-Cardo, Hiroaki Honda, Masaru Niki, Hisamaru Hirai

Publikováno v: The Journal of Experimental Medicine

Chronic myelogenous leukemia (CML) is characterized by the presence of the chimeric p210bcr/abl oncoprotein that shows elevated and constitutive protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase. Although several p210bcr/a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836f038fd3569de0791ada506ba4050e
https://doi.org/10.1084/jem.20041306

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

Autor: Pier Paolo Pandolfi, Kavita Shah, Friedhelm Bladt, Tony Pawson, Jean Y. J. Wang, Jill Meisenhelder, Sam A. Johnson, Guo-Lei Zhou, Tony Hunter, Pamela J. Woodring, Masaru Niki, Jeffrey Field

Publikováno v: The Journal of cell biology, vol 165, iss 4
The Journal of Cell Biology
Woodring, PJ; Meisenhelder, J; Johnson, SA; Zhou, GL; Field, J; Shah, K; et al.(2004). c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. Journal of Cell Biology, 165(4), 493-503. doi: 10.1083/jcb.200312171. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/740752hq

Filopodia are dynamic F-actin structures that cells use to explore their environment. c-Abl tyrosine kinase promotes filopodia during cell spreading through an unknown mechanism that does not require Cdc42 activity. Using an unbiased approach, we ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a1ab93cd914b38e0a3efff7f7db382
https://doi.org/10.1083/jcb.200312171

P62dok, a Negative Regulator of Ras and Mitogen-Activated Protein Kinase (Mapk) Activity, Opposes Leukemogenesis by P210bcr-abl

Autor: Fredrick G. Karnell, Bayard D. Clarkson, Mingming Zhao, Warren S. Pear, Masaru Niki, Antonio Di Cristofano, Linda Van Aelst, Pier Paolo Pandolfi

Publikováno v: The Journal of Experimental Medicine

p62(dok) has been identified as a substrate of many oncogenic tyrosine kinases such as the chronic myelogenous leukemia (CML) chimeric p210(bcr-abl) oncoprotein. It is also phosphorylated upon activation of many receptors and cytoplamic tyrosine kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b80da1e2f06ac8b59231e12906831d4
http://europepmc.org/articles/PMC2193466