Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Masaru Kanekiyo"'
Autor:
Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leuk
Externí odkaz:
https://doaj.org/article/086e3f3dbf7c436b9fc0aa65fce2326a
Autor:
Yuhe R. Yang, Julianna Han, Hailee R. Perrett, Sara T. Richey, Alesandra J. Rodriguez, Abigail M. Jackson, Rebecca A. Gillespie, Sarah O’Connell, Julie E. Raab, Lauren Y. Cominsky, Ankita Chopde, Masaru Kanekiyo, Katherine V. Houser, Grace L. Chen, Adrian B. McDermott, Sarah F. Andrews, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114171- (2024)
Summary: Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed adul
Externí odkaz:
https://doaj.org/article/a0c95ce71b2948fb906573474156e723
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012159 (2024)
Human enteroviruses are the most common human pathogen with over 300 distinct genotypes. Previous work with poliovirus has suggested that it is possible to generate antibody responses in humans and animals that can recognize members of multiple enter
Externí odkaz:
https://doaj.org/article/03502cb352934548b90cce83f5bbdec5
Autor:
Geoffrey B. Hutchinson, Olubukola M. Abiona, Cynthia T. Ziwawo, Anne P. Werner, Daniel Ellis, Yaroslav Tsybovsky, Sarah R. Leist, Charis Palandjian, Ande West, Ethan J. Fritch, Nianshuang Wang, Daniel Wrapp, Seyhan Boyoglu-Barnum, George Ueda, David Baker, Masaru Kanekiyo, Jason S. McLellan, Ralph S. Baric, Neil P. King, Barney S. Graham, Kizzmekia S. Corbett-Helaire
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notabl
Externí odkaz:
https://doaj.org/article/977b93340ceb4969a382e3a4758201f2
Autor:
Annie Dosey, Daniel Ellis, Seyhan Boyoglu-Barnum, Hubza Syeda, Mason Saunders, Michael J. Watson, John C. Kraft, Minh N. Pham, Miklos Guttman, Kelly K. Lee, Masaru Kanekiyo, Neil P. King
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113553- (2023)
Summary: The receptor-binding domain (RBD) of influenza virus hemagglutinin (HA) elicits potently neutralizing yet mostly strain-specific antibodies. Here, we evaluate the ability of several immunofocusing techniques to enhance the functional breadth
Externí odkaz:
https://doaj.org/article/3cefb334ae1442beba2b9a737c54329f
Autor:
Daniel Ellis, Annie Dosey, Seyhan Boyoglu-Barnum, Young-Jun Park, Rebecca Gillespie, Hubza Syeda, Geoffrey B. Hutchinson, Yaroslav Tsybovsky, Michael Murphy, Deleah Pettie, Nick Matheson, Sidney Chan, George Ueda, Jorge A. Fallas, Lauren Carter, Barney S. Graham, David Veesler, Masaru Kanekiyo, Neil P. King
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113552- (2023)
Summary: Immunogen design approaches aim to control the specificity and quality of antibody responses elicited by next-generation vaccines. Here, we use computational protein design to generate a nanoparticle vaccine platform based on the receptor-bi
Externí odkaz:
https://doaj.org/article/f0b10a69337b4749a61aac233ea0c282
Autor:
Masaru Kanekiyo, Rebecca A. Gillespie, Morgan Midgett, Katherine J. O’Malley, Connor Williams, Syed M. Moin, Megan Wallace, Luke Treaster, Kristine Cooper, Hubza Syeda, Gwenddolen Kettenburg, Hasala Rannulu, Tabitha Schmer, Lucia Ortiz, Priscila Da Silva Castanha, Jacqueline Corry, Mengying Xia, Emily Olsen, Daniel Perez, Gabin Yun, Barney S. Graham, Simon M. Barratt-Boyes, Douglas S. Reed
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107830- (2023)
Summary: Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model of
Externí odkaz:
https://doaj.org/article/64d9ec9d91b942c4adacf65285a4edf8
Autor:
Mallory L. Myers, John R. Gallagher, De’Marcus D. Woolfork, Regan K. Stradtmann-Carvalho, Samantha Maldonado-Puga, Kevin W. Bock, Seyhan Boyoglu-Barnum, Hubza Syeda, Adrian Creanga, Derron A. Alves, Masaru Kanekiyo, Audray K. Harris
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/bb7b3f7edfea42d98380f173f65a6023
Autor:
Dustin M McCraw, Mallory L Myers, Neetu M Gulati, Madhu Prabhakaran, Joshua Brand, Sarah Andrews, John R Gallagher, Samantha Maldonado-Puga, Alexander J Kim, Udana Torian, Hubza Syeda, Seyhan Boyoglu-Barnum, Masaru Kanekiyo, Adrian B McDermott, Audray K Harris
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011514 (2023)
Despite the availability of seasonal vaccines and antiviral medications, influenza virus continues to be a major health concern and pandemic threat due to the continually changing antigenic regions of the major surface glycoprotein, hemagglutinin (HA
Externí odkaz:
https://doaj.org/article/82d3481038c84757a30ef4e14fbf435c
Autor:
Sean A. Nelson, Katherine A. Richards, Maryah A. Glover, Francisco A. Chaves, Michelle C. Crank, Barney S. Graham, Masaru Kanekiyo, Andrea J. Sant
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Nanoparticle vaccines based on H. pylori ferritin are increasingly used as a vaccine platform for many pathogens, including RSV, influenza, and SARS-CoV-2. They have been found to elicit enhanced, long-lived B cell responses. The basis for i
Externí odkaz:
https://doaj.org/article/fdb8daa72b4e4c18aca6e6142b4badea