Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Masao Yuda"'
Publikováno v:
eLife, Vol 12 (2024)
Gametocytes play key roles in the Plasmodium lifecycle. They are essential for sexual reproduction as precursors of the gametes. They also play an essential role in parasite transmission to mosquitoes. Elucidation of the gene regulation at this stage
Externí odkaz:
https://doaj.org/article/b61fd853bc1d41a3aa2a575f6bf0cc82
Autor:
Shiroh Iwanaga, Rie Kubota, Tsubasa Nishi, Sumalee Kamchonwongpaisan, Somdet Srichairatanakool, Naoaki Shinzawa, Din Syafruddin, Masao Yuda, Chairat Uthaipibull
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Plasmodium falciparum malaria is treated using artemisinin combination therapy (ACT), in which artemisinin is supplied along with partner drugs such as mefloquine, piperaquine, and lumefantrine. However, resistance has been reported in endemic region
Externí odkaz:
https://doaj.org/article/994ca7c9bea84ed992fa78d880984241
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Malaria transmission to humans begins with sporozoite infection of the liver. The elucidation of gene regulation during the sporozoite stage will promote the investigation of mechanisms of liver infection by this parasite and contribute to t
Externí odkaz:
https://doaj.org/article/a5f4d958171e41f5ac4814595e0309a2
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1010890 (2023)
Gametocyte development is a critical step in the life cycle of Plasmodium. Despite the number of studies on gametocyte development that have been conducted, the molecular mechanisms regulating this process remain to be fully understood. This study in
Externí odkaz:
https://doaj.org/article/59decff1b8a1460c895491b6e2e372e9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The CRISPR/Cas9 system is a powerful genetic engineering technology for Plasmodium falciparum. We here report further improvement of the CRISPR/Cas9 system by combining the Cas9-expressing parasite with a liner donor template DNA. The Cas9-e
Externí odkaz:
https://doaj.org/article/b96891bd3e9d4dfa8a10bff40afe263f
Autor:
Yang Xu, Ziyou Zhou, Brad Brooks, Tammy Ferguson, Judy Obliosca, Jing Huang, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Yukiko Tsuji, Huitang Zhang, Christina C. Luo, Xunqing Jiang, Xiang-Peng Kong, Moriya Tsuji, Christopher K. Tison
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Developing a safe and effective malaria vaccine is critical to reducing the spread and resurgence of this deadly disease, especially in children. In recent years, vaccine technology has seen expanded development of subunit protein, peptide, and nucle
Externí odkaz:
https://doaj.org/article/01b7c35a60b940dea07528b88ec9daeb
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010510 (2022)
The sexual phase of Plasmodium represents a crucial step in malaria transmission, during which these parasites fertilize and form ookinetes to infect mosquitoes. Plasmodium development after fertilization is thought to proceed with female-stored mRNA
Externí odkaz:
https://doaj.org/article/ba188a7d30c04236878d9aadcf0281e3
Autor:
Ana Rafaela Teixeira, Begoña Pérez-Cabezas, David M. Costa, Mónica Sá, Sylvain Golba, Hélèna Sefiane-Djemaoune, Joana Ribeiro, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji, Silvia Beatriz Boscardin, Rogerio Amino, Anabela Cordeiro-da-Silva, Joana Tavares
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Malaria is a major public health concern, as a highly effective human vaccine remains elusive. The efficacy of a subunit vaccine targeting the most abundant protein of the sporozoite surface, the circumsporozoite protein (CSP) has been hindered by di
Externí odkaz:
https://doaj.org/article/39b48b40b8af477b896617e5648234ba
Autor:
Daniel Addo-Gyan, Haruka Matsushita, Enya Sora, Tsubasa Nishi, Masao Yuda, Naoaki Shinzawa, Shiroh Iwanaga
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Spatial arrangement of chromosomes is responsible for gene expression in Plasmodium parasites. However, methods for rearranging chromosomes have not been established, which makes it difficult to investigate its role in detail. Here, we report a metho
Externí odkaz:
https://doaj.org/article/6d16249d95b944a4993a3757844d5718
Publikováno v:
Expert Review of Vaccines, Vol 16, Iss 1, Pp 73-80 (2017)
Objectives: A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated sporozoites (RAS)-based malaria vaccine in mice. In the current study, we aim to determi
Externí odkaz:
https://doaj.org/article/ddfa46264bd04bb08225df93457a7ef6