Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Masao Ohashi"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Pericyclase enzymes are an expanding family of enzymes. Here, the authors identify the norbornene synthase SdnG, a pericyclase for the intramolecular Diels-Alder reaction between a cyclopentadiene and an olefinic dienophile to form the sordaricin nor
Externí odkaz:
https://doaj.org/article/7d335afb622f40cc83bd744b9064bc56
Publikováno v:
Journal of the American Chemical Society. 145:6643-6647
Autor:
Masao Ohashi, Dan Tan, Jiayan Lu, Cooper S. Jamieson, Daiki Kanayama, Jiahai Zhou, K. N. Houk, Yi Tang
Publikováno v:
Journal of the American Chemical Society. 145:3301-3305
Publikováno v:
Org Lett
Terpenoids are an important class of natural products with diverse structures and bioactivities. Their hydrocarbon scaffolds are mainly derived from the terpenes produced by terpene cyclases (TCs). Otherwise, new hydrocarbon scaffolds can be achieved
Publikováno v:
Org Lett
4-Hydroxy-2-pyridone alkaloids have attracted attention for synthetic and biosynthetic studies due to their broad biological activities and structural diversity. Here, we elucidated the pathway and chemical logic of (−)-sambutoxin (1) biosynthesis.
Publikováno v:
Natural product reports.
Covering: 2010 to 2022Heterologous expression of natural product biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of ne
Publikováno v:
Org Lett
Quinolone-containing natural products are widely found in bacterial, fungi and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here, we uncovered a concise nonribosomal peptide syn
Autor:
Jennifer Soto, Guojun Chen, Gianpietro Dotti, Peter Abdou, Zejun Wang, Di Wen, Denis Fourches, Yuqi Zhang, Qian Chen, Ming Liu, Song Li, Jinqiang Wang, Masao Ohashi, George Van Den Driessche, Zhen Gu, Hongjun Li, Quanyin Hu
Publikováno v:
Matter. 1:1203-1214
Summary Tumor-associated adipocytes promote tumor growth by providing energy and causing chronic inflammation. Here, we have exploited the lipid metabolism to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site.
Autor:
Yi Tang, Hosea M. Nelson, Matthew Asay, Dan Tan, Masao Ohashi, Jose A. Rodriguez, Zhuan Zhang, Lee Joon Kim, Duilio Cascio
Publikováno v:
Nature chemical biology, vol 17, iss 8
More than 60% of pharmaceuticals are related to natural products (NPs), chemicals produced by living organisms. Despite this, the rate of NP discovery has slowed over the past few decades. In many cases the rate-limiting step in NP discovery is struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3363a26376709357ceb0be41fa1d58d
https://escholarship.org/uc/item/80j7540x
https://escholarship.org/uc/item/80j7540x
Autor:
Mengting Liu, Masao Ohashi, Yiu-Sun Hung, Kenji Watanabe, Yi Tang, Christian Hertweck, Kirstin Scherlach
Publikováno v:
J Am Chem Soc
Enzymes that can perform halogenation of aliphatic carbons are of significant interests to the synthetic and biocatalysis communities. Here we describe the characterization of AoiQ, a single-component flavin-dependent halogenase (FDH) that catalyzes