Výsledky vyhledávání - "Masao Kimoto"

MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface

Autor: Ritsu Ito, Hiroki Tsukamoto, Yoshihisa Tomioka, Masao Kimoto, Yoshitaka Ikeda, Naoto Suzuki, Ippo Ukai, Hideyuki Ihara

Publikováno v: Biochemical and Biophysical Research Communications. 440:31-36

MD-2 is essential for lipopolysaccharide (LPS) recognition of Toll-like receptor 4 (TLR4) but not for cell surface expression. The TLR4/MD-2 complex is formed intracellularly through co-expression. Extracellular complex formation remains a matter for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455d1e5ec86f46d35d4cb0294eaaea15
https://doi.org/10.1016/j.bbrc.2013.09.004

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Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation

Autor: Kiyoshi Takatsu, Uleng Bahrun, Shoichiro Ohta, Kenji Fukudome, Masao Kimoto, Yoshinori Nagai, Tsutomu Yanagibashi, Naoko Tsuneyoshi, Nurlaely Mida Rachmawati, Hiroki Tsukamoto

Publikováno v: International Immunology. 25:117-128

Stimulation of Toll-like receptor 4 (TLR4) induces not only innate but also adaptive immune responses, and has been suggested to exert adjuvant effects. Additional to such positive effects, pre-stimulation of TLR4 induces endotoxin tolerance where an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c48dd77ce096bb05a22a8fb3259503
https://doi.org/10.1093/intimm/dxs096

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Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs

Autor: Hideyuki Ihara, Naoko Tsuneyoshi, Shoko Takao, Yoshitaka Ikeda, Masao Kimoto, Hiroki Tsukamoto, Kenji Fukudome

Publikováno v: International Immunology. 24:495-506

Recognition of LPS by the toll-like receptor 4 (TLR4)/MD-2 complex is a trigger of innate immune defense against bacterial invasion. However, excessive immune activation by this receptor complex causes septic shock and autoimmunity. Manipulation of T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd84b761efc7aea9eb4f858c3084d907
https://doi.org/10.1093/intimm/dxs053

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Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells

Autor: Masao Kimoto, Hiroki Tsukamoto, Kenji Fukudome, Naoko Tsuneyoshi, Shoko Takao

Publikováno v: International Immunology. 22:271-280

Toll-like receptor (TLR) 4/MD-2 dimerization is thought to be required for the initiation of signaling during innate immune responses. In this study, we examined the molecular mechanisms underlying receptor dimerization in the context of accessory mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74062cf2e05d1a5d1171cd4cc87be242
https://doi.org/10.1093/intimm/dxq005

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Preparation and Characterization of Agonistic Monoclonal Antibodies Against Toll-Like Receptor 4-MD-2 Complex

Autor: Hiroki Tsukamoto, Masao Kimoto, Uleng Bahrun, Kenji Fukudome, Jun Kohara, Naoko Tsuneyoshi

Publikováno v: Hybridoma. 26:393-400

Ligands for toll-like receptors (TLR) are known to induce a variety of immune responses. Selective induction of desirable responses would be important for the treatment of individual diseases with various pathogenesis. For this purpose, we establishe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0802bebc01a398e6d0dd52ed27c8c760
https://doi.org/10.1089/hyb.2007.0523

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Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies

Autor: Shino Takeuchi, Sao Kozakai, Hiroki Tsukamoto, Yoshihisa Tomioka, Yuki Yamagata, Kanae Kubota, Masao Kimoto, Ippo Ukai, Naoto Suzuki

Publikováno v: FEBS letters. 589(24 Pt)

Excessive activation of Toll-like receptor 4 (TLR4)/MD-2 by lipopolysaccharide (LPS) causes septic shock. We previously produced an inhibitory antibody, HT52, against LPS-induced human TLR4 activation independently of LPS binding of MD-2. Consistent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6164a6292b70d65665299d1855de533
https://pubmed.ncbi.nlm.nih.gov/26602081

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Induction of Long-Term Lipopolysaccharide Tolerance by an Agonistic Monoclonal Antibody to the Toll-Like Receptor 4/MD-2 Complex

Autor: Rintaro Shimazu, Shoichiro Ohta, Kenji Fukudome, Hidetomo Matsushita, Uleng Bahrun, Masao Kimoto

Publikováno v: Clinical and Vaccine Immunology. 13:1131-1136

We have established an agonistic monoclonal antibody, UT12, that induces stimulatory signals comparable to those induced by lipopolysaccharide (LPS) through Toll-like receptor 4 and MD-2. UT12 activated nuclear factor κB and induced the production o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad290e839ab2e95d39670125e0fb4a36
https://doi.org/10.1128/cvi.00173-06

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Preparation and Characterization of Monoclonal Antibodies to Thrombomodulin

Autor: Masao Kimoto, Naoko Tsuneyoshi, Kaoru Higuchi, Kenji Fukudome

Publikováno v: Hybridoma. 24:189-196

Thrombomodulin (TM) is an endothelial cell surface molecule, capable of specific binding for thrombin. The thrombin/TM complex promotes activation of plasma anticoagulant protein C (PC) and negatively regulates blood coagulation. Along with anticoagu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a144450e42ecea0b065df50272facd1
https://doi.org/10.1089/hyb.2005.24.189

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