Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Masao Kaneki"'
Publikováno v:
Metabolites, Vol 12, Iss 9, p 800 (2022)
Burn injury remains a significant public health issue worldwide. Metabolic derangements are a major complication of burn injury and negatively affect the clinical outcomes of severely burned patients. These metabolic aberrations include muscle wastin
Externí odkaz:
https://doaj.org/article/cbe410c41a6f48ab9b9f314e8ba733c4
Autor:
Naohide Kuriyama, Tomoyuki Nakamura, Harumasa Nakazawa, Tyler Wen, Lorenzo Berra, Edward A. Bittner, Jeremy Goverman, Masao Kaneki
Publikováno v:
Metabolites, Vol 12, Iss 7, p 613 (2022)
Mitochondrial dysfunction has been implicated in the pathogenesis of inflammation and multi-organ dysfunction in major trauma, including burn injury. Coenzyme Q10 (CoQ10) is a metabolite of the mevalonate pathway and an essential cofactor for the ele
Externí odkaz:
https://doaj.org/article/8237cd931f2c49468bed50e97812cae8
Autor:
Allison M Owen, Samir P Patel, Jeffrey D Smith, Beverly K Balasuriya, Stephanie F Mori, Gregory S Hawk, Arnold J Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G Rabchevsky, Timothy A Butterfield, Karyn A Esser, Charlotte A Peterson, Marlene E Starr, Hiroshi Saito
Publikováno v:
eLife, Vol 8 (2019)
Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of se
Externí odkaz:
https://doaj.org/article/2921515ccd0a436c8613cc46de0a4720
Autor:
Harumasa Nakazawa, Kazuhiro Ikeda, Shohei Shinozaki, Masayuki Kobayashi, Yuichi Ikegami, Ming Fu, Tomoyuki Nakamura, Shingo Yasuhara, Yong-Ming Yu, J. A. Jeevendra Martyn, Ronald G. Tompkins, Kentaro Shimokado, Tomoko Yorozu, Hideki Ito, Satoshi Inoue, Masao Kaneki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Noneth
Externí odkaz:
https://doaj.org/article/afe79a61568341ec8376c8fb9c5a6d31
Autor:
Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kaneki
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170391 (2017)
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. We and others have shown that inducible nitric oxide synthase (iNOS), a major mediator
Externí odkaz:
https://doaj.org/article/14c5f0c8233b4e7d8f0091f301afeab0
Autor:
Yoko Yamada, Masato Eto, Yuki Ito, Satoru Mochizuki, Bo-Kyung Son, Sumito Ogawa, Katsuya Iijima, Masao Kaneki, Koichi Kozaki, Kenji Toba, Masahiro Akishita, Yasuyoshi Ouchi
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136597 (2015)
Metabolic syndrome causes insulin resistance and is associated with risk factor clustering, thereby increasing the risk of atherosclerosis. Recently, endothelial nitric oxide synthase deficient (eNOS-/-) mice have been reported to show metabolic diso
Externí odkaz:
https://doaj.org/article/265b0c2a02fc4eb681de31c21a53e7e1
Autor:
Takamasa Tsuzuki, Shohei Shinozaki, Hideko Nakamoto, Masao Kaneki, Sataro Goto, Kentaro Shimokado, Hiroyuki Kobayashi, Hisashi Naito
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132029 (2015)
Voluntary exercise can ameliorate insulin resistance. The underlying mechanism, however, remains to be elucidated. We previously demonstrated that inducible nitric oxide synthase (iNOS) in the liver plays an important role in hepatic insulin resistan
Externí odkaz:
https://doaj.org/article/a6f8301c0c67427bbcb687bab80f19eb
Autor:
Harumasa Nakazawa, Marina Yamada, Tomokazu Tanaka, Joshua Kramer, Yong-Ming Yu, Alan J Fischman, J A Jeevendra Martyn, Ronald G Tompkins, Masao Kaneki
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116633 (2015)
OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a posttranslational lipid modification
Externí odkaz:
https://doaj.org/article/52ffc0e83e014b10845bffe620ce492d
Autor:
Akihiro Asai, Nita Sahani, Masao Kaneki, Yasuyoshi Ouchi, J A Jeevendra Martyn, Shingo Egusa Yasuhara
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e806 (2007)
Duchenne Muscular Dystrophy (DMD) is characterized by increased muscle damage and an abnormal blood flow after muscle contraction: the state of functional ischemia. Until now, however, the cause-effect relationship between the pathogenesis of DMD and
Externí odkaz:
https://doaj.org/article/a50d6fc6cb5c4723ab38cd44868b0abc
Autor:
Hideo Baba, Hiroshi Takamori, Masahiko Hirota, Satoshi Furuhashi, Masao Kaneki, Hiroki Sugita
Nitric oxide (NO), which plays a role in the posttranslational modification of proteins, exhibits tumoricidal activity. However, the mechanism remains largely unclear. We investigated whether the regulation of insulin receptor substrate (IRS)-1 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904127c3bafff4aaab65be3bd786f4f4
https://doi.org/10.1158/1541-7786.c.6542173.v1
https://doi.org/10.1158/1541-7786.c.6542173.v1