Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Masao Hiraiwa"'
Autor:
Nicole O'Brien, S. Tarran Jones, David G. Williams, H. Brad Cunningham, Kelli Moreno, Barbara Visentin, Angela Gentile, John Vekich, William Shestowsky, Masao Hiraiwa, Rosalia Matteo, Amy Cavalli, Douglas Grotjahn, Maria Grant, Geneviève Hansen, Mary-Ann Campbell, Roger Sabbadini
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 11, Pp 2245-2257 (2009)
Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid involved in multiple physiological processes. Importantly, dysregulated S1P levels are associated with several pathologies, including cardiovascular and inflammatory diseases and cancer.
Externí odkaz:
https://doaj.org/article/ec8f3648f48c40f293d4a40be6d4c008
Autor:
Kanemasa Fukuda, Yuka Takenaka, Masao Hiraiwa, Masakazu Kasuya, Yukako Kuramoto, Hiroshi Shimeno, Roberta Misasi, Shinji Soeda, Masahiko Kimura, Takashi Ochiai
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1780:1441-1447
Prosaposin triggers G-protein-coupled receptor (GPCR)-mediated protein kinase B (Akt)/extracellular signal-regulated kinase (ERK) phosphorylation cascades to exert its neurotrophic and myelinotrophic activity capable of preventing neural cell death a
Autor:
Masao Hiraiwa, Sabrina Molinari, Vincenzo Mattei, Laura Ciarlo, Maurizio Sorice, Luisa Di Marzio, Vincenzo Tasciotti, Tina Garofalo, Roberta Misasi
Publikováno v:
FEBS Journal. 275:4903-4912
Prosaposin is a neurotrophic factor that has been demonstrated to mediate trophic signalling events in different cell types; it distributes to surface membranes of neural cells and also exists as a secreted protein in different body fluids. Prosaposi
Autor:
T.-J. Lee, Masao Hiraiwa, Zoran Culig, Ardalan Minokadeh, Shahriar Koochekpour, Ruoxiang Wang, G.A. Grabowski, Nathalie Delorme, Ying Sun
Publikováno v:
Journal of Cellular Biochemistry. 101:631-641
Androgen-regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen-independent (AI) or me
Autor:
Haiyen E. Zhau, Charles L. Sawyers, Rameen Beroukhim, Mark A. Rubin, Joy L. Ware, Yujun Zhang, Robert L. Vessella, Shahriar Koochekpour, Kenneth J. Pienta, Matthias D. Hofer, Ronald B. Luftig, Daniel Y. Pattan, Oliver Sartor, William R. Sellers, Masao Hiraiwa, Konrad Sandhoff, Chia-Ling Hsieh
Publikováno v:
Genes, Chromosomes and Cancer. 44:351-364
We identified prosaposin (PSAP) as a secreted protein expressed in androgen-independent (AI) prostate cancer cells by cloning/sequencing, after probing a PC-3 cDNA library expressed in the λTriplEx phagemid expression vector with a polyclonal rabbit
Autor:
Masao Hiraiwa, Paola Del Bianco, Vincenzo Mattei, Sergio Scaccianoce, Roberta Misasi, Maurizio Sorice, Chiara Gizzi
Publikováno v:
Hippocampus. 14:275-280
Several studies indicate that stress can produce remarkable effects on neurotrophic factors. In this regard, hippocampus is the most interesting structure of the brain because of its broad involvement in behavioral and neuroendocrine phenomena. In th
Colocalization and Complex Formation Between Prosaposin and Monosialoganglioside GM3 in Neural Cells
Autor:
Maria Giammatteo, Masao Hiraiwa, Antonio Pavan, Maurizio Sorice, John S. O'Brien, T. Griggi, W M Campana, Giuseppe M. Pontieri, Tina Garofalo, Roberta Misasi
Publikováno v:
Scopus-Elsevier
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor in vitro as well as in vivo. Its neurotrophic activity has been localized to a linear 12-amino acid sequence located in the NH2-terminal portion of
Autor:
Lars Terenius, Ellen Hertz, Nikolas Stroth, Ebba Gregorsson Lundius, Vladana Vukojević, Per Svenningsson, Masao Hiraiwa, Andreas Cederlund
Publikováno v:
The Journal of biological chemistry. 289(8)
The subcellular distribution of the G protein-coupled receptor GPR37 affects cell viability and is implicated in the pathogenesis of parkinsonism. Intracellular accumulation and aggregation of GPR37 cause cell death, whereas GPR37 located in the plas
Publikováno v:
Glia. 26:353-360
Recently, we demonstrated that prosaposin and prosaptides (peptides encompassing the neurotrophic sequence in prosaposin) prevent cell death and increase extracellular regulated kinase (ERK) phosphorylation and sulfatide content in primary Schwann ce
Publikováno v:
The FASEB Journal. 12:307-314