Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Masanosuke Yoshikawa"'
Publikováno v:
Microbiology and Immunology. 45:497-506
Cytolethal distending toxin (CDT) has been found in various pathogenic bacterial species and causes a cell distending and a G2 arrest against eukaryotic cells. All the cdtABC genes, which encode CDT, are known to be required for the CDT activities al
Autor:
Hiroyuki Tsuji, Chihiro Sasakawa, Ruairí A. Mac Síomóin, Tatuo Murai, N. Nakata, Masanosuke Yoshikawa
Publikováno v:
Molecular Microbiology. 19:599-609
The virulent phenotype of Shigella requires loci on the chromosome as well as on the large virulence plasmid, and is regulated via a complex web of interactions amongst various chromosomal and large plasmid genes. To further investigate the role of c
Autor:
Masanosuke Yoshikawa, Toru Tobe, C. Sasakawa, Kei-ichi Uchiya, Toshihiko Suzuki, Masahisa Watarai, Ichirou Fukuda, K. Komatsu
Publikováno v:
Molecular Microbiology. 17:241-250
A novel virulence gene (virA) was identified upstream of the virG gene on the large plasmid of Shigella flexneri 2a YSH6000. Characterization of virA mutants infecting MK2 epithelial cell monolayers revealed that their invasive capacity was decreased
Autor:
H Munakata, Eisaku Katayama, C. Sasakawa, Toshiharu Suzuki, N Hayashi, Masanosuke Yoshikawa, I. Fukuda
Publikováno v:
Journal of Bacteriology. 177:1719-1726
The large plasmid-encoded outer membrane protein VirG (IcsA) of Shigella flexneri is essential for bacterial spreading by eliciting polar deposition of filamentous actin (F-actin) in the cytoplasm of epithelial cells. Recent studies have indicated th
Publikováno v:
Journal of Bacteriology. 177:1094-1097
Transcription of the virB gene, a transcriptional regulator of invasion genes on the large plasmid of Shigella flexneri, is strictly regulated by growth temperature; when bacteria are grown at 37 degrees C, virB transcription is highly activated, whi
Autor:
Ayako Kohno, Hideo Nariuchi, Masanosuke Yoshikawa, N Okada, Hirofumi Danbara, Mitsuru Nakayama, Masao Takasaka, Yasuhiro Yoshikawa, Hiroyuki Shimada, C. Sasakawa, Masaki Toriumi
Publikováno v:
Vaccine. 13:1436-1440
A virG thyA double mutant of Shigella flexneri 2a was constructed as a candidate live-attenuated oral vaccine. In the keratoconjunctivitis model it did not provoke any adverse reaction by itself on guinea pigs' eyes and completely protected them from
Autor:
Masanosuke Yoshikawa, Chihiro Sasakawa, I. Fukuda, Masahisa Watarai, Toshiharu Suzuki, N Nakata, K. Komatsu, Toru Tobe, J M Durand, N Okada
Publikováno v:
Journal of Bacteriology. 176:4627-4634
The genetic determinants required for invasion of epithelial cells by Shigella flexneri and for the subsequent bacterial spreading are encoded by the large virulence plasmid. Expression of the virulence genes is under the control of various genes on
Publikováno v:
Molecular Microbiology. 11:31-41
Summary Intercellular spreading of shigellae Is a prerequisite for shigellosis, although the molecular mechanisms underlying the phenomenon are still largely obscure. To elucidate some of these mechanisms, we performed random TniO insertion mutagenes
Autor:
Masanosuke Yoshikawa, Chihiro Sasakawa
Publikováno v:
Journal of the agricultural chemical society of Japan. 68:246-249
Publikováno v:
Journal of Bacteriology. 175:6142-6149
Expression of invasion genes encoded by the large 230-kb plasmid of Shigella flexneri is controlled by the virB gene, which is itself activated by another regulator, virF. Transcription of the invasion genes is temperature regulated, since they are a