Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Masanori Wakisaka"'
Autor:
Yutaro Hirashima, Toshiaki Nakano, Kumiko Torisu, Seishi Aihara, Masanori Wakisaka, Takanari Kitazono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to be renoprotective in ischemia-reperfusion (I/R) injury, with several proposed mechanisms, though additional mechanisms likely exist. This study investigated the impact of l
Externí odkaz:
https://doaj.org/article/58543e0d461e40c6957e870f9ac93c59
Autor:
Masamitsu Takashima, Kuniyuki Nakamura, Takuya Kiyohara, Yoshinobu Wakisaka, Masaoki Hidaka, Hayato Takaki, Kei Yamanaka, Tomoya Shibahara, Masanori Wakisaka, Tetsuro Ago, Takanari Kitazono
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Pre-treatment of non-diabetic mice with the SGLT2 inhibitor, luseogliflozin, reduces brain damage and neurological dysfunction following middle cerebral artery occlusion by acquiring ischemic tolerance in pericytes.
Externí odkaz:
https://doaj.org/article/fc79054bf7484c98ac90aeb360eb57f2
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151585 (2016)
PURPOSE:Mesangial cells play an important role in regulating glomerular filtration by altering their cellular tone. We report the presence of a sodium glucose cotransporter (SGLT) in rat mesangial cells. This study in rat mesangial cells aimed to eva
Externí odkaz:
https://doaj.org/article/784ba6ef3e7847b3a8f46f73aa0cbd50
Publikováno v:
Diabetes research and clinical practice. 192
SGLT2 is expressed in mesangial cells and pericytes, and is upregulated byhigh glucose and ischemia. Upregulated SGLT2 in both cells might directly worsen ischemia in kidney interstitial legion, heart and brain. The overexpression of SGLT2 in these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d95282a373267b2afbd6c1600771d8
https://pubmed.ncbi.nlm.nih.gov/36174778
https://pubmed.ncbi.nlm.nih.gov/36174778
Publikováno v:
Journal of the Endocrine Society
We have been studying the presence of sodium-glucose cotransporter 2 (SGLT2) in mesangial cells and pericytes since 1992. Recent large placebo-controlled studies of SGLT2 inhibitors in patients with type 2 diabetes mellitus have reported desirable ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3de00292a757483e8151980e38456d
https://doi.org/10.1210/jendso/bvab083
https://doi.org/10.1210/jendso/bvab083
Publikováno v:
The American Journal of Case Reports
Patient: Female, 63 Final Diagnosis: Diabetic macular edema Symptoms: Visual disturbance Medication: — Clinical Procedure: Treatment with sodium glucose transporter 2 inhibitor Specialty: Ophthalmology Objective: Unusual or unexpected effect of tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dc8dda0aec7aec0a47b641e6f12c20
https://doi.org/10.12659/ajcr.909708
https://doi.org/10.12659/ajcr.909708
Publikováno v:
International Journal of Molecular Sciences
Recent large placebo-controlled trials of sodium glucose co-transporter 2 (SGLT2) inhibitors revealed desirable effects on heart failure (HF) and renal dysfunction; however, the mechanisms underlying these effects are unknown. The characteristic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556c41644ac1ec5c494466606c82a83b
http://europepmc.org/articles/PMC6888253
http://europepmc.org/articles/PMC6888253
Autor:
Yasutaka Maeda, Masanori Wakisaka, Yoshihiro Ogawa, Toshinobu Maki, Sayaka Maeno, Noriyuki Sonoda, Toyoshi Inoguchi, Mayumi Yamato
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Several clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on diabetic nephropathy. The underlying mechanisms are not fully understood. We found that administration of canagliflozin at a low dose (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61069e6f14a6e9409e92ec91a6c06d91
http://europepmc.org/articles/PMC6423112
http://europepmc.org/articles/PMC6423112
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151585 (2016)
PLoS ONE
PLoS ONE
Purpose Mesangial cells play an important role in regulating glomerular filtration by altering their cellular tone. We report the presence of a sodium glucose cotransporter (SGLT) in rat mesangial cells. This study in rat mesangial cells aimed to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f93fb0b2a6edba75b176388bb436da3
http://europepmc.org/articles/PMC4801351?pdf=render
http://europepmc.org/articles/PMC4801351?pdf=render
Autor:
Mitsuo Iida, Hiroaki Ooboshi, Noriko Hagiwara, Setsuro Ibayashi, Masahiro Kamouchi, Tetsuro Ago, Kuniyuki Nakamura, Masanori Wakisaka, Takanari Kitazono, Junya Kuroda
Publikováno v:
Neuroscience Letters. 416:12-16
Objective: The aims of the present study were to elucidate the interaction of reactive oxygen species (ROS) and Ca2+ response in central nervous system (CNS) pericytes. Methods: The intracellular Ca2+ concentration was measured using fluorescent Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe66f4c1b22195613da4c38c3d1bfa7
https://doi.org/10.1016/j.neulet.2007.01.039
https://doi.org/10.1016/j.neulet.2007.01.039