Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Masanori Miwa"'
Autor:
Sachio Shibata, Satoshi Sogabe, Masanori Miwa, Takuya Fujimoto, Nobuyuki Takakura, Akihiko Naotsuka, Shuji Kitamura, Tomohiro Kawamoto, Tomoyoshi Soga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell pr
Externí odkaz:
https://doaj.org/article/f9c30a90aae44dd1abe0ffa04ef29aac
Autor:
Kotaro Sakamoto, Yoko Kanematsu-Yamaki, Yusuke Kamada, Masahiro Oka, Toshiyuki Ohnishi, Masanori Miwa, Taiji Asami, Hiroshi Inooka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 33-39 (2017)
ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with
Externí odkaz:
https://doaj.org/article/45d8df8431974c9889a7941bd6119f0a
Autor:
Fumito Takada, Takahito Kasahara, Kentaro Otake, Takamitsu Maru, Masanori Miwa, Kei Muto, Minoru Sasaki, Yoshihiko Hirozane, Masato Yoshikawa, Junichiro Yamaguchi
Publikováno v:
ACS medicinal chemistry letters. 13(9)
We report the discovery of two compounds, TKD150 and TKD152, that promote the aggregation of α-synuclein (aSN) using a real-time quaking-induced conversion (RT-QuIC) assay to detect abnormal aSN. By utilizing a Pd-catalyzed C-H arylation of benzoxaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79e7747819aea5c3676c37b62c2a7f0
https://pubmed.ncbi.nlm.nih.gov/36105342
https://pubmed.ncbi.nlm.nih.gov/36105342
Autor:
Tomoyoshi Soga, Satoshi Sogabe, Takuya Fujimoto, Tomohiro Kawamoto, Nobuyuki Takakura, Shuji Kitamura, Masanori Miwa, Sachio Shibata, Akihiko Naotsuka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4268160f6405b1c33fef5e186d4693a5
https://doi.org/10.21203/rs.3.rs-95794/v1
https://doi.org/10.21203/rs.3.rs-95794/v1
Autor:
Taiji Asami, Masahiro Oka, Yusuke Kamada, Yoko Kanematsu-Yamaki, Toshiyuki Ohnishi, Masanori Miwa, Kotaro Sakamoto, Hiroshi Inooka
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 33-39 (2017)
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 33-39 (2017)
ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec95b51ccd63a2fc1971367208fb1229
https://doi.org/10.1016/j.bbrep.2017.06.001
https://doi.org/10.1016/j.bbrep.2017.06.001
Autor:
Kazumasa Ogawa, Tomohiro Kawamoto, Kazuhiro Tsuchinaga, Kengo Okada, Tsutomu Henta, Masanori Miwa, Shoichi Ohkubo, Ryutaro Adachi, Robert J. Skene
Publikováno v:
Biochemical and Biophysical Research Communications. 488:393-399
Prolyl-tRNA synthetase (PRS) is a member of the aminoacyl-tRNA synthetase family of enzymes and catalyzes the synthesis of prolyl-tRNAPro using ATP, l-proline, and tRNAPro as substrates. An ATP-dependent PRS inhibitor, halofuginone, was shown to supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eda38696010c642c099155e1680748b
https://doi.org/10.1016/j.bbrc.2017.05.064
https://doi.org/10.1016/j.bbrc.2017.05.064
Autor:
Satoshi Sogabe, Ayumu Niida, Tomoya Sameshima, Kazuko Yonemori, Junichi Sakamoto, Masanori Miwa, Shigekazu Sasaki, Kotaro Sakamoto, Yusuke Kamada, Masahiro Kamaura
Publikováno v:
ACS Medicinal Chemistry Letters. 8:732-736
The Ras proteins play roles in cell differentiation, proliferation, and survival. Aberrant signaling through Ras-mediated pathways in tumor cells occurs as a result of several types of mutational damage, which most frequently affects the amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a09652ed8be2e587bf598942edbaef0
https://doi.org/10.1021/acsmedchemlett.7b00128
https://doi.org/10.1021/acsmedchemlett.7b00128
Publikováno v:
Biochemical and biophysical research communications. 503(3)
Vasoactive intestinal peptide receptor 2 (VIPR2, also known as VPAC2) is a class B G-protein coupled receptor (GPCR) and plays important roles in the physiology of central nervous system (CNS) by interaction with natural ligands; vasoactive intestina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f4438ef3e0d25d29f70d5995b2ada1
https://pubmed.ncbi.nlm.nih.gov/30077368
https://pubmed.ncbi.nlm.nih.gov/30077368
Autor:
Masanori Miwa, Tetsuro Tokoro
Publikováno v:
2017 International Symposium on Electrical Insulating Materials (ISEIM).
Since silicone rubber has good hydrophobicity, lightweight and stain-resistant, it is used for polymeric outdoor insulators. However, we have not evaluated the retention of hydrophobicity under AC and DC voltage stress yet. Therefore, CIGRE starts Dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5c40986739ace9bbca0c962574b735
https://doi.org/10.23919/iseim.2017.8088739
https://doi.org/10.23919/iseim.2017.8088739
Autor:
Michael G. Klein, Masanori Miwa, Daisuke Morishita, Kazuko Yonemori, Masahiro Ito, Toshio Tanaka, Atsushi Nakanishi, Richard Tjhen, Ling Qin, Hironobu Maezaki, Tomohiro Kawamoto, Takeshi Yamamoto, Satoshi Endo, Misa Iwatani-Yoshihara
Publikováno v:
Journal of medicinal chemistry. 60(13)
Brr2 is an RNA helicase belonging to the Ski2-like subfamily and an essential component of spliceosome. Brr2 catalyzes an ATP-dependent unwinding of the U4/U6 RNA duplex, which is a critical step for spliceosomal activation. An HTS campaign using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d0731eca68c6f35ea0913ed644693e
https://pubmed.ncbi.nlm.nih.gov/28586220
https://pubmed.ncbi.nlm.nih.gov/28586220