Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Masanori Kayano"'
Publikováno v:
Japanese Journal of Hospital Pharmacy. 25:169-175
A simple and sensitive reversed-phase high-performance liquid chromatographic method was developed for the analysis of warfarin (WF) in both human serum and serum ultrafiltrate. WF and internal standard (I.S.) were extracted from the serum by simple
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 688:101-106
A sensitive reversed-phase high-performance liquid chromatographic (HPLC) method with fluorescence detection was developed for the analysis of a new angiotensin II receptor antagonist, E4177, in human plasma and urine. The analyte and internal standa
Publikováno v:
Drug Development and Industrial Pharmacy. 21:2227-2237
Tablets containing anhydrous theophylline, a hygroscopic material such as magnesium chloride or potassium acetate, and other constituents were stored for 4 and 12 weeks under 90% relative humidity at 37°C. During storage, whisker-like crystals appea
Publikováno v:
International Journal of Pharmaceutics. 85:29-38
Solved mixtures of hydrogels (SMH), composed of hydroxypropylcellulose (HPC), a pseudo-hydrogel, and ethylcellulose, a water-insoluble polymer, were prepared by solvent evaporation. Phenylpropanolamine hydrochloride was used as a model drug. The amou
Publikováno v:
International Journal of Pharmaceutics. 85:65-73
The dissolution behavior of two controlled-release matrix tablets, formualtions A and B, containing phenylpropanolamine HCl as a model drug was studied using a paddle method and a paddle-beads procedure. The paddle-beads method involves a system in w
Publikováno v:
Drug Development and Industrial Pharmacy. 18:453-467
Needle-like crystals appeared on the surface of theophylline tablets containing anhydrous theophylline, hygroscopic materials such as potassium, and other formulation ingredients, when stored under conditions of high relative humidity. X-ray powder d
Autor:
Masanori Kayano, Akira Matsumoto, Eiji Uchida, Shinichi Kobayashi, Sumiko Takahashi, Katsuji Oguchi, Hajime Yasuhara, Kenji Nakano, Tomio Takamatsu, Shigeyuki Iida, Hitoshi Sakai
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 23:651-656
The urinary excretion of metabolites of bifemelane hydrochloride (BFM) was studied in both young and elderly volunteers. BFM (50mg) was administered orally after breakfast to young healthy subjects (n=8) and elderly subjects (n=15). Urine was collect
Autor:
Masanori Kayano, Hiroshi Ozawa, Tomoaki Hino, Hirofumi Takeuchi, Toshiyuki Niwa, Yoshiaki Kawashima, Hiroshi Sakamoto, Eiji Kawakatsu, Katsumi Ida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:472-478
Phospholipid nanosphere dispersions incorporating a lipophilic drug were prepared by the heating method. Prepared dispersions were powdered by depositing them on sugar nuclei in a fluidized-bed granulator in an aqueous system. Resultant free-flowing
Autor:
Yoshiaki Kawashima, Katsumi Ida, Hiroshi Ozawa, Toshiyuki Niwa, Masanori Kayano, Hirofumi Takeuchi, Tomoaki Hino, Eiji Kawakatsu
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:1911-1916
Phospholipid nanosphere dispersion was prepared from phosphatidylcholine with or without vitamin E by the heating method. The dispersed particles had diameters of 8.6-150 nm. These nanosphere dispersions were powdered with sugars such as sucrose, lac
Publikováno v:
Journal of Pharmaceutical Sciences. 80:1153-1156
In a previous study, we developed a multiple-unit type of oral floating dosage system, which is a new type of floating pill composed of both an effervescent layer and a swellable membrane layer coated on sustained-release pills. The system was shown