Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Masanori Hizue"'
1
An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury
Autor: Lisa D. Marroquin, Eri Uchida, Yuka Uchida, Shingo Oda, Jessica Whritenour, Yusuke Matsui, Petra H. Koza-Taylor, Masanori Hizue, Michael D. Aleo, Tsuyoshi Yokoi
Publikováno v: Archives of toxicology. 95(1)
Preventing clinical drug-induced liver injury (DILI) remains a major challenge, because DILI develops via multifactorial mechanisms. Immune and inflammatory reactions are considered important mechanisms of DILI; however, biomarkers from in vitro syst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716b856555d39f4d7ee672de894ec245
https://pubmed.ncbi.nlm.nih.gov/32816093
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2
Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies
Autor: Masanori Hizue, Shizuo Yamada, Kimio Sugaya, Hidetomi Yamagami, Katsumi Kadekawa, Saori Nishijima, Yoshihiko Ito
Publikováno v: Lower Urinary Tract Symptoms
Objectives To examine the effect of combining a nonselective muscarinic receptor antagonist, 5‐hydroxymethyl tolterodine (an active metabolite of fesoterodine), with a β3 adrenoceptor agonist, mirabegron, in a rat model of pelvic congestion. Metho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2a65421761c720f39e9fd11049a3c1
https://pubmed.ncbi.nlm.nih.gov/31758673
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3
Synergy between a NR2B receptor antagonist DHQ and 3-methyl-gabapentin in mice with neuropathic pain
Autor: Aki Imai, Masanori Hizue, Katsuo Toide
Publikováno v: European Journal of Pharmacology. 588:244-247
The synergistic effect of a selective NR2B NMDA receptor antagonist, (−)-(R)-6-{2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl-3,4-dihydro-2(1H)-quinolinone (DHQ), and a α2δ ligand, 3-methyl-gabapentin (3M-GBP), was investigated in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421874ec890a4740aed4ac0834c7ac74
https://doi.org/10.1016/j.ejphar.2008.04.033
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4
Adverse Drug Reactions for Medicines Newly Approved in Japan from 1999 to 2013: Hypertension and Hypotension
Autor: Takashi Nagayama, Masato Fujiyoshi, Yamato Ogino, Masanori Hizue, Minoru Nishida
Publikováno v: Basicclinical pharmacologytoxicology. 118(4)
In this survey, the correlation between adverse drug reactions (ADRs) in human and animal toxicities was investigated for 393 medicines which were approved in Japan from September 1999 to March 2013. ADRs were collected from each Japanese package ins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6b4c379c82c48d832c9008eb800131
https://pubmed.ncbi.nlm.nih.gov/26407539
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6
Pharmacological Studies on the Novel Antiallergic Drug HQL-79: I. Antiallergic and Antiasthmatic Effects in Various Experimental Models
Autor: Masanori Hizue, Kumi Hayashi, Ichiro Hirotsu, Nobutoshi Matsushita, Yoshiyuki Kimura, Tadato Tani, Kazuhiko Mitsui, Masatoshi Hayashi, Ayumi Takada, Kosuke Aritake, Hiromichi Nakajima
Publikováno v: Japanese Journal of Pharmacology. 78:1-10
The effects of oral administration of 4-benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]piperidine (HQL-79), a newly synthesized antiallergic drug, in various experimental allergic and asthmatic models were investigated. HQL-79 markedly inhibited immedi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e60ef028117635bd5e512e55b7e8c
https://doi.org/10.1254/jjp.78.1
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7
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan
Autor: Kazuhiko Suzuki, Takashi Nagayama, Yasuo Yoneta, Kazuichi Nakamura, Chihiro Tamaki, Masanori Hizue, Yamato Ogino, Daisaku Yasugi, Masamichi Hashiba, Yoshiharu Takashima, Hiroshi Kodaira, Masato Fujiyoshi, Minoru Nishida, Shigeru Hisada, Takako Ohkura
Publikováno v: The Journal of toxicological sciences. 38(4)
The objective of this study was to elucidate the range of abilities of nonclinical safety assessment for predicting adverse drug reactions (ADRs) in humans. The dataset included 1256 ADRs with an incidence rate of 5% or more collected from 142 drugs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3288624d1998cdff9d0fa3bf569d5b
https://pubmed.ncbi.nlm.nih.gov/23824014
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8
Enantiotopic Selectivity in Monodemethylation of Fenitrothion by Rat Liver Glutathione S-Transferase Isoenzymes and Mouse Liver Cytosol
Autor: Masanori Hizue, Norio Kurihara, Hiroshi Nozaki, Koji Wakabayashi, Mitsuru Nakayama
Publikováno v: Journal of Pesticide Science. 19:277-284
Monodemethylation of fenitrothion catalyzed by any of five purified glutathione S-transferases from rat liver predominantly produced the (S P ) -(-)-enantiomer of desmethyl fenitrothion. Mouse liver cytosolic fraction demethylated fenitrothion in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60dce6bc43142f9ddb34a2f4fdaf6cf4
https://doi.org/10.1584/jpestics.19.4_277
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9
[Pharmacological profile and clinical findings of Maraviroc (Celsentri® Tablets)]
Autor: Masanori, Hizue
Publikováno v: Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 136(6)
マラビロクは，HIV（human immunodeficiency virus）が宿主細胞に侵入する際に補受容体として利用するCCケモカイン受容体5（CCR5）に対して選択的に作用するCCR5阻害薬である．既存の抗HIV薬とは
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9420ae4437645da822b6bfa20e413163
https://pubmed.ncbi.nlm.nih.gov/21139287
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