Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Masanori, Yoshinaga"'
Autor:
Noriki Iwai, Kotaro Akaki, Fabian Hia, Wei Li, Masanori Yoshinaga, Takashi Mino, Osamu Takeuchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The ATP-dependent RNA helicase UPF1 plays a crucial role in various mRNA degradation pathways, most importantly in nonsense-mediated mRNA decay (NMD). Here, we show that UPF1 is upregulated during the early stages of B cell development and i
Externí odkaz:
https://doaj.org/article/4a18ea25ea8f464a96d19444bd27e11f
Autor:
Masanori Yoshinaga, Osamu Takeuchi
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-14 (2024)
Abstract Inflammation orchestrates a finely balanced process crucial for microorganism elimination and tissue injury protection. A multitude of immune and non-immune cells, alongside various proinflammatory cytokines and chemokines, collectively regu
Externí odkaz:
https://doaj.org/article/5bd0604507614f37ba666f00762fa3a1
Autor:
Masanori Yoshinaga
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 6, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/f4ffe7dd97af4d5aaafdcb2abb6a3690
Autor:
Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai, Pedro H. C. Cruz, Alexis Vandenbon, Yutaka Suzuki, Yukio Kawahara, Izuho Hatada, Michael C. Bassik, Osamu Takeuchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In this work, Yoshinaga et al. use functional CRISPR screens and in vivo analyses to show that an RNA methyltransferase METTL16 and MTR4-nuclear exosome play an essential role in maintaining erythropoiesis and regulating DNA repair in erythroblasts.
Externí odkaz:
https://doaj.org/article/f78942b01fb44792b4c4ca4cc22d55e8
Autor:
Masanori Yoshinaga, Osamu Takeuchi
Publikováno v:
Immunological Medicine, Vol 42, Iss 2, Pp 53-64 (2019)
Autoimmune disease is induced by the breakdown of immune tolerance to self-antigens. This is brought about by an imbalance between the activation and the repression of immune responses. Dysregulation of the immune response is driven by the excess of
Externí odkaz:
https://doaj.org/article/e4baf719748c4152b02b6b744c0b7687
Autor:
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1614-1630 (2017)
Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we
Externí odkaz:
https://doaj.org/article/4478bd5cf27044d5a529b547ea52d3dc
Autor:
Masanori Yoshinaga, Osamu Takeuchi
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 6, Pp n/a-n/a (2019)
Abstract Inflammation is the host response against stresses such as infection. Although the inflammation process is required for the elimination of pathogens, uncontrolled inflammation leads to tissue destruction and inflammatory diseases. To avoid t
Externí odkaz:
https://doaj.org/article/c1025cde7a2142e3817e43f2177e4bb3
Autor:
Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Makoto Kinoshita, Tatsusada Okuno, Osamu Takeuchi
Publikováno v:
Science Translational Medicine. 14
Regnase-1 is an ribonuclease that plays essential roles in restricting inflammation through degrading messenger RNAs (mRNAs) involved in immune reactions via the recognition of stem-loop (SL) structures in the 3′ untranslated regions (3′UTRs). Dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936c7cb1dc16967d36a8ffd4025b207c
https://doi.org/10.1126/scitranslmed.abo2137
https://doi.org/10.1126/scitranslmed.abo2137
Autor:
Yee Kien Chong, Sarang Tartey, Yuki Yoshikawa, Koshi Imami, Songling Li, Masanori Yoshinaga, Ai Hirabayashi, Guohao Liu, Alexis Vandenbon, Fabian Hia, Takuya Uehata, Takashi Mino, Yutaka Suzuki, Takeshi Noda, Dominique Ferrandon, Daron M. Standley, Yasushi Ishihama, Osamu Takeuchi
Publikováno v:
Science Signaling. 15
Toll-like receptor (TLR) stimulation induces glycolysis and the production of mitochondrial reactive oxygen species (ROS), both of which are critical for inflammatory responses in macrophages. Here, we demonstrated that cyclin J, a TLR-inducible memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2e93383911afcd00ee76510da5c4b2
https://doi.org/10.1126/scisignal.abm5011
https://doi.org/10.1126/scisignal.abm5011
Autor:
Masanori, Yoshinaga, Kyuho, Han, David W, Morgens, Takuro, Horii, Ryosuke, Kobayashi, Tatsuaki, Tsuruyama, Fabian, Hia, Shota, Yasukura, Asako, Kajiya, Ting, Cai, Pedro H C, Cruz, Alexis, Vandenbon, Yutaka, Suzuki, Yukio, Kawahara, Izuho, Hatada, Michael C, Bassik, Osamu, Takeuchi
Publikováno v:
Nature communications. 13(1)
During erythroid differentiation, the maintenance of genome integrity is key for the success of multiple rounds of cell division. However, molecular mechanisms coordinating the expression of DNA repair machinery in erythroid progenitors are poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe4886e01524ebe8390334a64d9dd9ce
https://pubmed.ncbi.nlm.nih.gov/36307435
https://pubmed.ncbi.nlm.nih.gov/36307435