Zobrazeno 1 - 10
of 608
pro vyhledávání: '"Masanobu Uchiyama"'
Autor:
Takafumi Nakano, Yasuhisa Oida, Shinichi Morimoto, Kentaro Muranishi, Soichiro Ushio, Takuya Yamashina, Masanobu Uchiyama, Kenichi Mishima, Kiyoyuki Kitaichi, Yoshihiko Nakamura, Koichi Matsuo
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Background Fentanyl is widely used as an analgesic and sedative for patients with severe burn injuries in intensive care units. However, pharmacokinetic (PK) data for fentanyl, particularly for continuous intravenous infusion during the acut
Externí odkaz:
https://doaj.org/article/6fdd3d0357a14b8e8072e4b38aed2e85
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Photolysis is an attractive method in organic synthesis to produce free radicals through direct bond cleavage. However, in this method, specific irradiation wavelengths of light have been considered indispensable for excitation through S0–
Externí odkaz:
https://doaj.org/article/145cbd5962854ec4b0d3dc51605424a7
Autor:
Shiho Ishigaki, Yuki Nagashima, Daiki Yukimori, Jin Tanaka, Takashi Matsumoto, Kazunori Miyamoto, Masanobu Uchiyama, Ken Tanaka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Organoboron and organosilicon compounds have potential applications in various fields including materials science and medicinal chemistry. Here the authors report a protocol that enables the dearomative carbo-sila-boration of quinolines.
Externí odkaz:
https://doaj.org/article/497613bd44ca452ca4c93f983cd6f43f
Autor:
Yuta Matsukawa, Atsuya Muranaka, Tomotaka Murayama, Masanobu Uchiyama, Hikaru Takaya, Yoichi M. A. Yamada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract We demonstrated microwave-assisted photooxidation of sulfoxides to the corresponding sulfones using ethynylbenzene as a photosensitizer. Efficiency of the photooxidation was higher under microwave irradiation than under conventional thermal
Externí odkaz:
https://doaj.org/article/8c63cc9d5e9e4a5ba23c24b2384e95f9
Publikováno v:
JACS Au, Vol 1, Iss 8, Pp 1231-1239 (2021)
Externí odkaz:
https://doaj.org/article/fad9f8c4ae6e40c2971cf4956c10a244
Autor:
Junki Morimoto, Kazunori Miyamoto, Yuki Ichikawa, Masanobu Uchiyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Decreasing the partition coefficient (LogP) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. Since melting point is related to aqueo
Externí odkaz:
https://doaj.org/article/6da4c61e46e044feab315317688174ce
Autor:
Mio Matsumura, Takahiro Teramoto, Masato Kawakubo, Masatoshi Kawahata, Yuki Murata, Kentaro Yamaguchi, Masanobu Uchiyama, Shuji Yasuike
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 671-677 (2021)
Phosphole-fused π-conjugated acenes have been attracting interest because of the attractive features of the phosphole moiety, such as fluorescence and chemically modifiable properties. Herein, 6-phenyl-6H-benzo[f]naphtho[2,3-b]phosphoindole was prep
Externí odkaz:
https://doaj.org/article/0ce9979f2a8244e98d2ed54c033991c5
Publikováno v:
BMC Health Services Research, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background The substantial increase in the use of expensive anticancer drugs has been accompanied by an increase in the amount of disposing residual liquid from drug preparations. Many Western countries, including the United States, have imp
Externí odkaz:
https://doaj.org/article/96f1b9ca53314ef9a76c0dc7ea350b7c
Autor:
Kazunori Miyamoto, Shodai Narita, Yui Masumoto, Takahiro Hashishin, Taisei Osawa, Mutsumi Kimura, Masahito Ochiai, Masanobu Uchiyama
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Diatomic carbon (C2) is historically an elusive chemical species, considered to require high physical energy for its generation. Here, the authors describe the first room-temperature chemical synthesis of C2 and present experimental evidence for its
Externí odkaz:
https://doaj.org/article/67317a9a45f645f189f2bed624424990
Autor:
Motoyasu Miyazaki, Koichi Matsuo, Masanobu Uchiyama, Yoshihiko Nakamura, Yuya Sakamoto, Momoko Misaki, Kaoko Tokura, Shiro Jimi, Keisuke Okamura, Sen Adachi, Tomohiko Yamamoto, Kazuyuki Shirai, Hidenori Urata, Osamu Imakyure
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 6, Iss 1, Pp 1-11 (2020)
Abstract Background Inappropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical safety and efficacy; however, little is known about clinical data associated with an inappropriate DOAC dosing in Japan. In addition, the
Externí odkaz:
https://doaj.org/article/ceba16bf961246adabeb4c98dae885b4