Výsledky vyhledávání - "Masanobu Shinoda"

Akademický článek

Antidiabetic and Hypolipidemic Effects of a Novel Dual Peroxisome Proliferator-Activated Receptor (PPAR) α/γ Agonist, E3030, in db/db Mice and Beagle Dogs

Autor: Shunji Kasai, Takashi Inoue, Hideki Yoshitomi, Taro Hihara, Fumiyoshi Matsuura, Hitoshi Harada, Masanobu Shinoda, Isao Tanaka

Publikováno v: Journal of Pharmacological Sciences, Vol 108, Iss 1, Pp 40-48 (2008)

We investigated the antidiabetic effects of E3030, which is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) α and PPARγ, in an animal model of diabetes, C57BL/KsJ-db/db mice (db/db mice), and the lipidemic effects of E3

Externí odkaz: https://doaj.org/article/664910121db649939e3a89f3fc927c2c

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Antidiabetic and Hypolipidemic Effects of a Novel Dual Peroxisome Proliferator-Activated Receptor (PPAR) α/γ Agonist, E3030, in db/db Mice and Beagle Dogs

Autor: Taro Hihara, Fumiyoshi Matsuura, Hideki Yoshitomi, Masanobu Shinoda, Isao Tanaka, Takashi Inoue, Hitoshi Harada, Shunji Kasai

Publikováno v: Journal of Pharmacological Sciences, Vol 108, Iss 1, Pp 40-48 (2008)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f048ba19ead866a5a4a914c844ede9
http://www.sciencedirect.com/science/article/pii/S1347861319313726

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Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats

Autor: Richard Clark, Takashi Inoue, Isao Tanaka, Kazuto Yamazaki, Masanobu Shinoda, Yukiko Sugaya, Tadashi Nagakura, Eiichi Yamamoto, Takao Saeki, Nobuyuki Yasuda

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 320:738-746

Several combination therapies have been tried for treating of type 2 diabetes to control more effectively fasting hyperglycemia and postprandial hyperglycemia. In this study, we have examined the effects of combining a novel, selective, and competiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48f38d1e8c7ce752e129dcf2c2d4767
https://doi.org/10.1124/jpet.106.112011

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Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

Autor: C. Abe, Hiroshi Shirota, Masanobu Shinoda, K. Chiba, Naoki Nagakura, Numata Hirotoshi, Seiichi Kobayashi, Tatsuo Horizoe

Publikováno v: Inflammation Research. 48:432-436

Objective and Design: To investigate effects of ER-34122, a novel dual 5-lipoxygenase (LOX)/cyclooxygenase (COX) inhibitor, and indomethacin on progression of articular lesions in MRL/MpJ-lpr/lpr (MRL/l) mice.¶Material: 100 male MRL/l mice.¶Treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422aa26d224a019d3a95e203a758c0d8
https://doi.org/10.1007/s000110050483

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ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model

Autor: Hiroshi Shirota, K. Chiba, Tatsuo Horizoe, Seiichi Kobayashi, Numata Hirotoshi, Naoki Kobayashi, Naoki Nagakura, Masanobu Shinoda, Yasushi Okamoto

Publikováno v: Inflammation Research. 47:375-383

Objective and Design: To investigate the effect of ER-34122, a novel pyrazole derivative, on 5-lipoxygenase (LOX) and cyclooxygenase (COX) metabolite production in vitro, ex vivo and in vivo.¶Material: In vitro, lysate of rat basophilic leukemia cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e61b38f300a265e811563681b31cb0e
https://doi.org/10.1007/s000110050347

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Structure−Activity Relationships of (E)-3-(1,4-Benzoquinonyl)-2-[(3-pyridyl)- alkyl]-2-propenoic Acid Derivatives That Inhibit Both 5-Lipoxygenase and Thromboxane A2 Synthetase

Autor: Isao Yamatsu, Katsuya Tagami, Kokichi Harada, Numata Hirotoshi, Masanobu Shinoda, Tetsuya Kawahara, Kaname Miyamoto, Shigeki Hibi, Naoki Kobayashi, Yasushi Okamoto

Publikováno v: Journal of Medicinal Chemistry. 39:3148-3157

As part of our research for the development of novel antiinflammatory drug candidates, we have designed and synthesized a series of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)alkyl]-2-propenoic acid derivatives as dual inhibitors of 5-lipoxygenase (5-LO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7588b7bd6ce1503ffa62ce64365cf31
https://doi.org/10.1021/jm950725r

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Radio frequency plasma sputter type heavy negative ion source

Autor: Masanobu Shinoda, Junzo Ishikawa, Hiroshi Tsuji, Yukio Okada, Yasuhito Gotoh

Publikováno v: Vacuum. 44:203-207

A rf plasma sputter type heavy negative ion source with mA-class ion currents in dc operation has been developed. Although maximum negative ion production efficiencies by sputtering on a cesiated sputtering target surface were high (about 10% or more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e58406cc7f2522d20a2793b701471600
https://doi.org/10.1016/0042-207x(93)90154-3

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ChemInform Abstract: Structure-Activity Relationships of (E)-3-(1,4-Benzoquinonyl)-2-((3- pyridyl)alkyl)-2-propenoic Acid Derivatives That Inhibit Both 5- Lipoxygenase and Thromboxane A2 Synthetase

Autor: Naoki Kobayashi, Kokichi Harada, Yasushi Okamoto, Tetsuya Kawahara, Isao Yamatsu, Kaname Miyamoto, Katsuya Tagami, Numata Hirotoshi, Masanobu Shinoda, Shigeki Hibi

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f25f82de8e74b16352822a9ebb363bf
https://doi.org/10.1002/chin.199648146

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E3710, a new proton pump inhibitor, with a long-lasting inhibitory effect on gastric acid secretion

Autor: Hiroki Terauchi, Hiroshi Kato, Sou Yasui, Daisuke Iida, Masanobu Shinoda, Yoshikuni Tabata, Kotaro Kodama, Hitoshi Harada, Hiroko Kuramochi, Tetsuya Kawahara, Masato Ueda, Hideaki Fujisaki, Junichi Nagakawa, Kubota Atsuhiko, Miki Murota, Shuhei Miyazawa, Kazuo Hirota, Nobuhisa Watanabe

Publikováno v: The Journal of pharmacology and experimental therapeutics. 334(2)

We have investigated the pharmacology of sodium (R)-2-[4-(2,2-dimethyl-1,3-dioxan-5-yl) methoxy-3,5-dimethylpyridin-2-yl]methylsulfinyl-1H-benzimidazol (E3710), a new proton pump inhibitor (PPI), and its effect on gastric acid secretion. E3710 irreve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b06d5f878b1b39eab24295f04c7ebd
https://pubmed.ncbi.nlm.nih.gov/20484556

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7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity

Autor: Kazuto Yamazaki, Isao Tanaka, Masanobu Shinoda, Takashi Inoue, Takao Saeki, Kazunobu Kira, Nobuyuki Yasuda, Tadashi Nagakura

Publikováno v: The Journal of pharmacology and experimental therapeutics. 319(3)

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one (ER-319711) is a novel dipeptidyl peptidase (DPP)-IV inhibitor discovered in our laboratories. In this study, we have characterized this DPP-IV inhibitor in vitro and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e88e5cf7f409c9090e3a44e1b47821
https://pubmed.ncbi.nlm.nih.gov/16980568

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