Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Masanobu Naruto"'
Publikováno v:
International Immunopharmacology. 3:609-614
A converting activity was characterized in human diploid fibroblasts, which secrete 72IL-8 and 77IL-8 in treatment with IFN-β and poly I: poly C. 77IL-8 was significantly converted to 72IL-8 by a partially purified fraction of the culture supernatan
Publikováno v:
Journal of Interferon & Cytokine Research. 16:995-1000
Circulating interleukin-6 (IL-6) levels are directly correlated to fatal outcome in both patients and animal models with endotoxin shock. However, whether IL-6 is deleterious or protective in regard to survival is obscure. We investigated the action
Autor:
Shizuo Akira, Xue-Jie Wang, Yukihiro Nishio, Taiji Matsusaka, Masanobu Naruto, Masahiro Inoue, Tadamitsu Kishimoto, Tetsuo Sudo, Shi We, Kanji Yoshida
Publikováno v:
Cell. 77:63-71
Acute-phase response factor (APRF) is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. We report here the purification and cloning of APRF. APRF exhibi
Effects of natural human interleukin-6 on thrombopoiesis and tumor progression in tumor-bearing mice
Autor:
Akiko Izawa, Nobutaka Ida, Tasuku Okamoto, Masanobu Naruto, Yu-ichiro Satoh, Ken-ichi Yoshizawa, Keiko Moriya
Publikováno v:
Cancer Letters. 79:83-89
The growth of inoculated colon 26 adenocarcinoma (colon 26) in mice gradually increased the platelet count owing to murine IL-6 secreted from the tumor, while Lewis lung carcinoma (LLC) decreased the platelet count in the hosts, depending on the tumo
Autor:
Shizuo Akira, Tatsuru Sasagawa, Shigemi Kinoshita, Koichi Sasaki, Tadamitsu Kishimoto, Masanobu Naruto, Toshihiro Nakajima
Publikováno v:
Proceedings of the National Academy of Sciences. 90:2207-2211
NF-IL6, a member of the basic leucine zipper (bZIP) family transcription factors, is involved in expression of inducible genes involved in immune and inflammatory responses. We observed that coexpression of oncogenic p21ras stimulated the transactiva
Autor:
Emiko Sano, Keigo Endo, Masanobu Naruto, Kensaku Ohashi, Kaoru Tohyama, Yataro Yoshida, Hisataka Kobayashi, Toru Nakamura
Publikováno v:
Japanese Journal of Cancer Research : Gann
A multiple growth factor-producing tumor cell line (NIM-1) was newly established from a patient with thyroid cancer and remarkable neutrophilia. NIM-1 cells also caused severe neutrophilia in nude mice bearing tumors. NIM-1-conditioned medium (NIM-1C
Publikováno v:
Biochemical and Biophysical Research Communications. 167:1326-1332
We have cloned a full length cDNA for human leukocyte elastase (HLE, EC 3.4.21.37)/medullasin from the cDNA library of human leukemic cell line, ML3. Recombinant plasmid for the expression of HLE cDNA in eukaryotic cells was constructed in which HLE
Publikováno v:
Biochimica et biophysica acta. 1649(1)
IL-8 is produced by various cells, and the NH2-terminal amino acid sequence of IL-8 displays heterogeneity among cell types. The mature form of IL-8 has 72 amino acids (72IL-8), while a precursor form (77IL-8) of IL-8 has five additional amino acids
Autor:
Hiroyuki Anaguchi, Masanobu Naruto, Hitoaki Okazaki, Kensaku Ohashi, Masakazu Hattori, Ritsuko Sawada, Nagahiro Minato
Publikováno v:
DNA and cell biology. 9(3)
To identify the primary structure of CD59 antigen and to elucidate its function, a full-length cDNA clone of CD59 was isolated. The cDNA sequence contained an open reading frame that encodes an 128-amino-acid peptide. The amino-terminal 25 amino acid
Autor:
Kiyoshi Okano, Masahiko Iizuka, Sigeyasu Kobayashi, Emiko Sano, Koichi Kamata, Tetsuo Sudo, Ritsuko Sawada, Masanobu Naruto
Publikováno v:
Cell Structure and Function. 13:143-159
Two expression plasmids (pSVIFN gamma/BPV97 and pSVIFN gamma/AdDHFR) for constitutive production of human interferon-gamma (HuIFN-gamma) were constructed and introduced into the two different mammalian cell lines, mouse C127 cells and Chinese hamster