Výsledky vyhledávání - "Masanobu Komiya"

Novel, Highly Potent Aldose Reductase Inhibitors: (R)-(−)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3‘-pyrrolidine-1,2‘,3,5‘-tetrone (AS-3201) and Its Congeners

Autor: Kenji Suzuki, Jun-Ichi Matsumoto, Makoto Murata, Toshiyuki Negoro, Yoshiyuki Ono, Buichi Fujitani, Akemi Kuromiya, Masanobu Komiya, Ueda Shozo

Publikováno v: Journal of Medicinal Chemistry. 41:4118-4129

A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors (ARIs) on the basis of their abilities to inhibit porcine lens aldose reductase (AR) in vitro and to inhibit sorbitol accumul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9528354190fd338af75d0f5c468a2e4
https://doi.org/10.1021/jm9802968

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ChemInform Abstract: Novel, Highly Potent Aldose Reductase Inhibitors: (R)-(-)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo [1,2-a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone (AS-3201) and Its Congeners

Autor: Buichi Fujitani, Jun-Ichi Matsumoto, Makoto Murata, Toshiyuki Negoro, Akemi Kuromiya, Kenji Suzuki, Yoshiyuki Ono, Masanobu Komiya, Ueda Shozo

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::512bdb8cec62e9730ccb4f61dfdf1b3b
https://doi.org/10.1002/chin.199911179

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Improvement of 5-HT3 Receptor Binding Assay: Enhancement of Specific [3H]Quipazine Binding with Triton X-100-Treated Membranes from Rat Cortex

Autor: Masanobu Komiya, Kiyoshi Furukawa, Teruaki Une

Publikováno v: Japanese Journal of Pharmacology. 57:197-203

The 5-hydroxytryptamine (5-HT)3 receptor binding assay using [3H]quipazine was examined. It was impossible to obtain specific [3H]quipazine binding with the membrane fractions from rat cortex prepared by the usual procedure. When the membranes were p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8a21463840fab9c38eeb52f7a1a585
https://doi.org/10.1254/jjp.57.197

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Proteolysis of human tumor necrosis factor (TNF) by endo- and exopeptidases: process of proteolysis and formation of active fragments

Autor: Masanobu Komiya, Keiji Nakamura

Publikováno v: Biologicalpharmaceutical bulletin. 19(5)

Recombinant human tumor necrosis factor (TNF) was digested with endopeptidases under mild conditions. Incubation of the TNF (155-amino-acid TNF) with trypsin, Staphylococcus aureus V-8 protease or chymotrypsin initially released small peptides derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7859af794e9727041b6ff3346f39da
https://pubmed.ncbi.nlm.nih.gov/8741573

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Pharmacologic properties of a novel Ca2+ entry blocker, AJ-2615, in vitro

Autor: Mikio Kurokawa, Takashi Nukuda, Buichi Fujitani, Teruaki Une, Kiyoshi Furukawa, Hirofumi Okamura, Masanobu Komiya

Publikováno v: Journal of cardiovascular pharmacology. 22(6)

We studied the in vitro vascular relaxant properties of AJ-2615, (+/-)-N-[6,11-dihydrodibenzo[b,e]-thiepin-11-yl]-4-[4- fluorophenyl]-1-piperazinebutanamide monomaleate, a novel compound with long-lasting antihypertensive activity. AJ-2615 inhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89297708dd7cf859cab6f8c0ca52c53
https://pubmed.ncbi.nlm.nih.gov/7509897

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