Výsledky vyhledávání - "Masanobu Kawai"

Akademický článek

Factors associated with low bone mineral density in Turner syndrome: a multicenter prospective observational study

Autor: Kento Ikegawa, Eri Koga, Tomoyo Itonaga, Hideya Sakakibara, Masanobu Kawai, Yukihiro Hasegawa

Publikováno v: Endocrine Journal, Vol 71, Iss 6, Pp 561-569 (2024)

Turner syndrome (TS) is associated with a high risk of fracture due to low bone mineral density (BMD). While hypogonadism is known to play a role in decreasing BMD, other factors have not been studied well. Focusing on diet, exercise, and bone metabo

Externí odkaz: https://doaj.org/article/ff3f977af4fa4045a39c7616b9989b81

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Akademický článek

Skeletal Characteristics of Children and Adolescents with Turner Syndrome

Autor: Masanobu Kawai, Yukihiro Hasegawa

Publikováno v: Endocrines, Vol 3, Iss 3, Pp 476-487 (2022)

Turner syndrome (TS) is a chromosomal disorder characterized by a short stature and gonadal dysgenesis, the latter of which requires estrogen replacement therapy (ERT) to induce and maintain secondary sexual characteristics. Insufficient ERT is assoc

Externí odkaz: https://doaj.org/article/d2df93cef6244237a55b1f40752508d3

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Akademický článek

Pubertal induction in Turner syndrome without gonadal function: A possibility of earlier, lower-dose estrogen therapy

Autor: Yukihiro Hasegawa, Tomonobu Hasegawa, Mari Satoh, Kento Ikegawa, Tomoyo Itonaga, Marie Mitani-Konno, Masanobu Kawai

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Delayed and absent puberty and infertility in Turner syndrome (TS) are caused by primary hypogonadism. A majority of patients with TS who are followed at hospitals during childhood will not experience regular menstruation. In fact, almost all patient

Externí odkaz: https://doaj.org/article/c6a2e79f36c04ccd89e88025d421dc58

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Akademický článek

Constitutional mismatch repair deficiency in childhood colorectal cancer harboring a de novo variant in the MSH6 gene: a case report

Autor: Keinosuke Hizuka, Shin-ichiro Hagiwara, Takatoshi Maeyama, Hitoshi Honma, Masanobu Kawai, Kiwamu Akagi, Michiko Yasuhara, Naohiro Tomita, Yuri Etani

Publikováno v: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-6 (2021)

Abstract Background Constitutional mismatch repair deficiency (CMMRD) is caused by biallelic pathogenic variants in one of the mismatch repair genes, and results in early onset colorectal cancer, leukemia, brain tumors and other childhood malignancie

Externí odkaz: https://doaj.org/article/48b0b1b0743c4afab9404bf39cc76449

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Akademický článek

Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels

Autor: Masanobu Kawai, Saori Kinoshita, Keiichi Ozono, Toshimi Michigami

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Abstract Fibroblast growth factor 23 (FGF23) has been centric to the regulation of phosphate (Pi) metabolism; however, the regulatory network of FGF23 in osteocytes has not yet been defined in detail. We herein investigated the role of PTEN (phosphat

Externí odkaz: https://doaj.org/article/7d2edd74e21949f0a5221a6d3d04539a

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Akademický článek

Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.

Autor: Kazuaki Miyagawa, Miwa Yamazaki, Masanobu Kawai, Jin Nishino, Takao Koshimizu, Yasuhisa Ohata, Kanako Tachikawa, Yuko Mikuni-Takagaki, Mikihiko Kogo, Keiichi Ozono, Toshimi Michigami

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93840 (2014)

Osteocytes express multiple genes involved in mineral metabolism including PHEX, FGF23, DMP1 and FAM20C. In Hyp mice, a murine model for X-linked hypophosphatemia (XLH), Phex deficiency results in the overproduction of FGF23 in osteocytes, which lead

Externí odkaz: https://doaj.org/article/039439087a5d4e2880e218a3b22cb5d7

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