Výsledky vyhledávání - "Masanobu Funamoto"

CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation

Autor: Junichi Azuma, Masanobu Funamoto, Yasushi Fujio, Tsuyoshi Fukuda, Chieko Nakajima-Taniguchi, Risa Ueki, Tomoko Kubota, H Hara, Makiko Maeda, K Kawashima, E Tange

Publikováno v: The Pharmacogenomics Journal. 6:115-119

CYP2A6 is the main enzyme that catalyzes nicotine into cotinine. Interindividual differences in nicotine metabolism result at least partially from polymorphic variation of CYP2A6 gene. In this study, we evaluated the influence of CYP2A6 polymorphisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0ea5e367d71e69e1ff430cc58f37b8
https://doi.org/10.1038/sj.tpj.6500348

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Final results of the CAPAS trial

Autor: Etsuo Tsuchikane, Masahiro Izumi, Nobuhisa Awata, Masanobu Funamoto, Tohru Kobayashi, Satoru Otsuji, Satoru Sumitsuji, Makoto Sakurai, Tomoko Kobayashi

Publikováno v: American Heart Journal. 142:782-789

The Cutting Balloon (Interventional Technologies Inc) is a new-concept balloon that incorporates 3 to 4 blades to create sharp incisions on the luminal surface of the lesion during dilation without causing severe tearing injury to the vessel wall. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09727b3d182b173a0f2fc340e6989ef9
https://doi.org/10.1067/mhj.2001.119129

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Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway

Autor: Yoshikazu Nakaoka, Masahiro Izumi, Tomoaki Osugi, Keiko Yamauchi-Takihara, Keita Kunisada, Tadamitsu Kishimoto, Masanobu Funamoto, Shinji Negoro, Yuichi Oshima, Hisao Hirota, Yasushi Fujio, Eiro Tone

Publikováno v: Journal of Biological Chemistry. 276:31133-31141

Bone morphogenetic protein (BMP)-2 has been shown to induce ectopic expression of cardiac transcription factors and beating cardiomyocytes in non-precardiac mesodermal cells, suggesting that BMP-2 is an inductive signaling molecule that participates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8a0470c25ff6eff1e30ed8306c64c2
https://doi.org/10.1074/jbc.m101463200

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Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes

Autor: Kazuyuki Yoshizaki, Masahiro Izumi, Eiroh Tone, Masanobu Funamoto, Tomoaki Osugi, Keiko Yamauchi-Takihara, Tadamitsu Kishimoto, Kenneth Walsh, Keita Kunisada, Hisao Hirota, Shinji Negoro, Yasushi Fujio

Publikováno v: Journal of Biological Chemistry. 275:10561-10566

Activation of glycoprotein (gp) 130 transduces hypertrophic and cytoprotective signals in cardiac myocytes. In the present study, we have demonstrated that signals through gp130 increase the expression of vascular endothelial growth factor (VEGF) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4defecdda6ea0f95ae441f03e1d047
https://doi.org/10.1074/jbc.275.14.10561

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Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Autor: Keiko Yamauchi-Takihara, Tadamitsu Kishimoto, Masahiro Izumi, Keita Kunisada, Martine I. Darville, Shinji Negoro, Yoshikazu Nakaoka, Yuichi Oshima, Decio L. Eizirik, Tomoaki Osugi, Hisao Hirota, Masanobu Funamoto, Yasushi Fujio

Publikováno v: Circulation. 104:979-981

Background Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3 signal may be involved in the detoxification of reactive oxygen species (ROS). M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7a233c63253f24b7ca3cb50bbbb798
https://doi.org/10.1161/hc3401.095947

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Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients

Autor: Yasuhiko Takemoto, Masanobu Funamoto, Shinpei Nonen, Yuiko Masunaga, Akiko Yamamoto, Yasushi Fujio, Junichi Azuma, Ayumu Ono, Yasushi Kouno, Genta Miura, Tomoko Tanabe, Kinya Otsu, Masako Ohno

Publikováno v: European journal of clinical pharmacology. 65(11)

The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population.We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a96cfc41720bde73234194a1eec9e
https://pubmed.ncbi.nlm.nih.gov/19582440

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Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor

Autor: Ichiro Kawase, Hirokazu Uyama, Yorihide Okuda, Kenya Yoshida, Hideji Nakamura, Allen D. Everett, Masanobu Funamoto, Tomonori Hirotani, Hirayuki Enomoto, Hiroaki Ito, Toshikazu Hada

Publikováno v: Cancer science. 94(12)

Hepatoma-derived growth factor (HDGF) is highly expressed in tumor cells, and stimulates their proliferation. In the present study, we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. Stable transfectants of NIH3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9bceed7e7cdba1c75c9e5d975b5a88
https://pubmed.ncbi.nlm.nih.gov/14662017

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Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

Autor: Shinji Negoro, Eiroh Tone, Yasushi Fujio, Yoshikazu Nakaoka, Masahiro Izumi, Keiko Yamauchi-Takihara, Masanobu Funamoto, Hisao Hirota, Tomoaki Osugi, Yuichi Oshima, Keita Kunisada

Publikováno v: Cardiovascular research. 53(4)

Objective: We recently reported that doxorubicin (Dox), an effective anti-cancer drug, induces apoptosis in cardiac myocytes in association with reduction of Bcl-xl expression. In the present study, we further examined whether overexpression of Bcl-x

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd65fac8b214f17765fd395c67d707be
https://pubmed.ncbi.nlm.nih.gov/11922903

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Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart

Autor: Atsuko Yamashita, Keita Kunisada, Shinji Negoro, Masahiro Izumi, Tadamitsu Kishimoto, Yasushi Fujio, Masaru Okabe, Yuichi Oshima, Tomoaki Osugi, Hisao Hirota, Masanobu Funamoto, Yoshikazu Nakaoka, Ichiro Kawase, Keiko Yamauchi-Takihara

Publikováno v: The Journal of biological chemistry. 277(8)

Signal transducer and activator of transcription 3 (STAT3) functions in cell proliferation, differentiation, and cell survival. Previously, we have demonstrated that the activation of STAT3 is required for glycoprotein 130-mediated induction of VEGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c982912a5f30d311f02278df613814
https://pubmed.ncbi.nlm.nih.gov/11744720

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Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

Autor: Keiko Yamauchi-Takihara, Hidemasa Oh, Masanobu Funamoto, Keita Kunisada, Shinji Negoro, Eiroh Tone, Tadamitsu Kishimoto

Publikováno v: Cardiovascular research. 47(4)

Objectives: We reported that the activation of gp130 transduced hypertrophic and cytoprotective signals via Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in cardiac myocytes. Recent in vivo experiments have demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae901d9ea7d95d1b8a44cc0127b6696
https://pubmed.ncbi.nlm.nih.gov/10974228

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