Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Masano Sugiyama"'
Publikováno v:
Organic Process Research & Development. 18:636-642
A new and efficient process to prepare di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, from chloromethyl chlorosulfate (CMCS) and di-tert-butyl potassium phosphate (DTBPP) is described. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31457cd7a11d23d6b17bbd8b42bfcc29
https://doi.org/10.1021/op500066f
https://doi.org/10.1021/op500066f
Autor:
Boguslaw Mudryk, Adrian Ortiz, Zhongping Shi, James R. Sawyer, David A. Conlon, David R. Kronenthal, Bin Zheng, Masano Sugiyama, Ian S. Young, R. Michael Corbett, Amit Joshi, Jale Muslehiddinoglu
Publikováno v:
Synlett. 24:305-312
An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514 ( 1 ) is described. Strategic modifications in both approach and procedure addressed several issues, which led to a safe, efficient, and economical proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::246b3cef3de6de011e6f199343bd6e72
https://doi.org/10.1055/s-0032-1317540
https://doi.org/10.1055/s-0032-1317540
Autor:
David A. Conlon, Bin Zheng, Martin D. Eastgate, Saravanababu Murugesan, Fritz Alan W, Masano Sugiyama
Publikováno v:
Organic Process Research & Development. 16:1827-1831
A new and efficient synthesis of chloromethyl chlorosulfate (CMCS) from chloroiodomethane and chlorosulfonic acid is described. This process leverages a chlorosulfonic acid-mediated iodide oxidation to drive the equilibrating displacement process to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53cc3b33062758785a12f6d1e9bf70a
https://doi.org/10.1021/op300246d
https://doi.org/10.1021/op300246d
Autor:
Ling Chen, Qi Gao, Zhiwei Guo, Masano Sugiyama, Cuniere Nicolas, Lopa V. Desai, Jason Zhu, Yi Hsiao, Thorsten Rosner, Yu Fan, Collin Chan, David K. Leahy, Guanglin Luo, Ronald L. Hanson
Publikováno v:
Organic Letters. 14:4938-4941
An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new synthesis showcases a chemo- and enantioselective reduction of a cyclohepta[b]pyridine-5,9-dione as well as a Pd-catalyzed al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702037661a40da959f209ef00178f87a
https://doi.org/10.1021/ol302262q
https://doi.org/10.1021/ol302262q
Publikováno v:
Crystal Growth & Design. 8:4208-4214
A continuously fed microfluidic chamber has been developed for determination of solution phase diagrams for protein−precipitant systems. Laminar flow and diffusion in the chamber create significant gradients in concentration, so crystals form in on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d36c93ba2d23069aeaeb02c2eed63d67
https://doi.org/10.1021/cg800657k
https://doi.org/10.1021/cg800657k
Autor:
Masano Sugiyama, Vanessa Grife, Marc Rubenzik, Eva V. Varga, Henry I. Yamamura, Victor J. Hruby, Kenner C. Rice, William R. Roeske, Dagmar Stropova
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:109-115
Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance, dependence, and withdrawal. In the present study, we investigated the involvement of protein kinases in chronic delta-opioid agonist-mediated AC superacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee90274cb050858806c2eb97482700f
https://doi.org/10.1124/jpet.103.049643
https://doi.org/10.1124/jpet.103.049643
Autor:
Masano Sugiyama, Adrian Ortiz, Zhongping Shi, Yi Hsiao, Ian S. Young, Melissa Chau, David A. Conlon, James R. Sawyer, R. Michael Corbett, Amarjit Singh
Publikováno v:
Organicbiomolecular chemistry. 10(27)
Four synthetic strategies were evaluated towards the preparation of (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol (1), which was constructed with control over the relative and absolute stereochemistry of the 4,3-amino alcohol moiety. The first s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d327e94abe43a2c9ebf72fd6f1a75d
https://pubmed.ncbi.nlm.nih.gov/22648308
https://pubmed.ncbi.nlm.nih.gov/22648308
Autor:
Masano Sugiyama, Victor H. Barocas
Publikováno v:
ASME 2009 Summer Bioengineering Conference, Parts A and B.
A protein’s atomic level three-dimensional structure is typically determined by X-ray diffraction of a high-quality protein crystal (Figure 1a). The X-ray bream is diffracted inside the crystal producing spots at various locations (Figure 1b) which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4cb1c1dbedf092ce8fcf9330a558df
https://doi.org/10.1115/sbc2009-205229
https://doi.org/10.1115/sbc2009-205229
Publikováno v:
Lab on a chip. 8(8)
A continuously-fed crystallization chamber that allows for kinetic path control through the crystallization phase diagram (from labile/nucleation to metastable/growth) was fabricated and used to crystallize lysozyme. A lumped kinetic model was develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120e11ce89a2d0bf4b6fe46019ab8493
https://pubmed.ncbi.nlm.nih.gov/18651085
https://pubmed.ncbi.nlm.nih.gov/18651085
Autor:
Eva V. Varga, William R. Roeske, Masano Sugiyama, Vanessa Grife, Dagmar Stropova, Henry I. Yamamura, Marc Rubenzik
Publikováno v:
European Journal of Pharmacology. 451:101-102
Chronic delta-opioid receptor agonist treatment of Chinese hamster ovary (CHO) cells stably expressing the human delta-opioid receptor (hDOR/CHO) leads to increased cAMP formation after the removal of the agonist (adenylyl cyclase superactivation). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2f3249b73fb1036f3ec974c5165eea
https://doi.org/10.1016/s0014-2999(02)02220-3
https://doi.org/10.1016/s0014-2999(02)02220-3