Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Masamitsu Shimazawa"'
Autor:
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health. In this study, we conducted pharmacological exper
Externí odkaz:
https://doaj.org/article/b3f0c584a6654d6986335acb20a55dc8
Autor:
Kanta Yamazaki, Kodai Ishida, Wataru Otsu, Aomi Muramatsu, Shinsuke Nakamura, Wakana Yamada, Hideshi Tsusaki, Hiroshi Shimoda, Hideaki Hara, Masamitsu Shimazawa
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Blue light exposure is known to induce reactive oxygen species (ROS) production and increased endoplasmic reticulum stress, leading to apoptosis of photoreceptors. Maqui berry (Aristotelia chilensis) is a fruit enriched in anthocy
Externí odkaz:
https://doaj.org/article/d865dad8afd8404b82ffe56ad659dd73
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 10, Pp 395-411 (2023)
Abstract Myocardial infarction (MI) is a lethal disease that causes irreversible cardiomyocyte death and subsequent cardiovascular remodeling. We have previously shown that the administration of recombinant progranulin (PGRN) protects against myocard
Externí odkaz:
https://doaj.org/article/e5899a43e4154047b0d500b993546eaf
Autor:
Wataru Otsu, Tomohiro Yako, Emi Sugisawa, Shinsuke Nakamura, Hideshi Tsusaki, Naofumi Umigai, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 279-288 (2022)
The corneal epithelium is located at the outermost layer of the ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV) radiation from sunlight. UV irradiation causes excessive production of reactive oxygen species
Externí odkaz:
https://doaj.org/article/ebe40e94454f4839a05ac87daad2912d
Autor:
Wataru Otsu, Naoki Chinen, Emi Sugisawa, Haru Kitano, Shinsuke Nakamura, Naofumi Umigai, Hideshi Tsusaki, Masamitsu Shimazawa
Publikováno v:
Journal of Functional Foods, Vol 106, Iss , Pp 105611- (2023)
Tobacco smoke contains many toxic chemicals, such as highly unstable free radicals, reactive oxygen species, and carbonyl compounds such as acrolein. Crocetin, a natural carotenoid found in plants, has various biological properties, including antioxi
Externí odkaz:
https://doaj.org/article/e97c947ccec24118a02be51149ea0696
Autor:
Hirofumi Matsubara, Takahiko Imai, Shohei Tsuji, Natsumi Oka, Yusuke Egashira, Yukiko Enomoto, Noriyuki Nakayama, Shinsuke Nakamura, Masamitsu Shimazawa, Toru Iwama, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 65-72 (2022)
This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the management of subarachnoid hemorrhage (SAH). SAH was induced by endovascular perforation in male mice. Nafamostat was administered intraperitoneally four times
Externí odkaz:
https://doaj.org/article/7cdb7c0464d34752bdf319921347a145
Autor:
Honoka Fujimori, Takuya Ohba, Masashi Mikami, Shinsuke Nakamura, Kenichi Ito, Hiroyuki Kojima, Tatsuji Takahashi, Arunasiri Iddamalgoda, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 162-171 (2022)
Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia
Externí odkaz:
https://doaj.org/article/3d55ef5857af4bbaaa120fb1b9bc7cec
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 4, Pp 367-375 (2021)
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-indu
Externí odkaz:
https://doaj.org/article/f23ab132a29f4a4b80ae396a6cbf0861
Autor:
Wataru Morozumi, Kota Aoshima, Satoshi Inagaki, Yuki Iwata, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 211-221 (2021)
Trabecular meshwork (TM) regulates the intraocular pressure (IOP) through the control of aqueous humor outflow. Previous reports show that TM cells express 11 types of mechanosensitive molecules, including Piezo 1, which sense mechanical stimuli. How
Externí odkaz:
https://doaj.org/article/e1ffb3e5e9c445d5913be6528669d20e
Autor:
Yakumo Aoyama, Satoshi Inagaki, Kota Aoshima, Yuki Iwata, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 200-207 (2021)
Leber hereditary optic neuropathy (LHON) is caused by mitochondrial DNA mutations and is the most common inherited mitochondrial disease. It is responsible for central vision loss in young adulthood. However, the precise mechanisms of onset are unkno
Externí odkaz:
https://doaj.org/article/5ec818b32baa4fd7a98f4e587a05750c