Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Masamichi Kimura"'
Autor:
Mayu Yoshida, Juntaro Matsuzaki, Koji Fujita, Masamichi Kimura, Tomohiro Umezu, Noi Tokuda, Tomoko Yamaguchi, Masahiko Kuroda, Takahiro Ochiya, Yoshimasa Saito, Kiminori Kimura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract There is an unmet need for antifibrotic therapies to prevent the progression of liver cirrhosis. Previously, we conducted an exploratory trial to assess the safety and antifibrotic efficacy of PRI-724, a selective CBP/β-catenin inhibitor, i
Externí odkaz:
https://doaj.org/article/e973a4feb8e641d6a1cfb726a0e430a8
Autor:
Hiroyuki Gatanaga, Tsunamasa Watanabe, Masayuki Kurosaki, Masamichi Kimura, Jun Imamura, Ichiro Ieiri, Kiminori Kimura, Junko Tanuma, Mikio Yanase, Tomoyuki Endo, Hiroshi Yotsuyanagi
Publikováno v:
BMJ Open Gastroenterology, Vol 11, Iss 1 (2024)
Objective Patients with haemophilia and HIV who acquire hepatitis C virus (HCV) after receiving contaminated blood products can experience accelerated progression of liver fibrosis and a poor prognosis, making liver disease a prominent cause of morta
Externí odkaz:
https://doaj.org/article/1600739dd4794fb68b8346d1ff583f63
Publikováno v:
Cancers, Vol 16, Iss 2, p 320 (2024)
In this retrospective study, we investigated the potential application of serum stem cell growth factor beta (SCGF-β) as a biomarker for predicting the therapeutic response and prognosis in patients with hepatocellular carcinoma (HCC) undergoing ate
Externí odkaz:
https://doaj.org/article/efde027cf8fd45a1b9c39878ac3bcbba
Autor:
Masamichi Kimura, Koji Nishikawa, Yosuke Osawa, Jun Imamura, Kenzaburo Yamaji, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Kouichi Miura, Atsushi Tanaka, Tatsuya Kanto, Michinori Kohara, Terumi Kamisawa, Kiminori Kimura
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2732-2747 (2022)
Abstract Chronic cholestatic liver diseases are characterized by injury of the bile ducts and hepatocytes caused by accumulated bile acids (BAs) and inflammation. Wnt/β‐catenin signaling is implicated in organ fibrosis; however, its role in choles
Externí odkaz:
https://doaj.org/article/d5276f048b864db68f6d4c442a93004d
Autor:
Eiichi Ogawa, Atsushi Tanaka, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Masamichi Kimura, Jun Imamura, Masanao Saio, Yoshihiro Ikura, Kouichi Miura, Ichiro Ieiri, Kiminori Kimura
Publikováno v:
BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)
Objective This study aimed to evaluate the safety and tolerability of OP-724, a CREB-binding protein/β-catenin inhibitor, in patients with advanced primary biliary cholangitis (PBC).Design An open-label, non-randomised, phase 1 trial was conducted a
Externí odkaz:
https://doaj.org/article/cabfe85f53b94df4a8a96a71c3bfa66f
Autor:
Kiminori Kimura, Tatsuya Kanto, Shinji Shimoda, Kenichi Harada, Masamichi Kimura, Koji Nishikawa, Jun Imamura, Eiichi Ogawa, Masanao Saio, Yoshihiro Ikura, Takuji Okusaka, Kazuaki Inoue, Tetsuya Ishikawa, Ichiro Ieiri, Junji Kishimoto, Koji Todaka, Terumi Kamisawa
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104069- (2022)
Summary: Background: We conducted an exploratory study to assess the safety tolerability, and anti-fibrotic effects of PRI-724, a CBP/β-catenin inhibitor, in patients with hepatitis C virus (HCV)- and hepatitis B virus (HBV)-induced cirrhosis. Metho
Externí odkaz:
https://doaj.org/article/a68a8544980a4b5a8162b15098cfe871
Autor:
Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 79-87 (2017)
Background: There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt si
Externí odkaz:
https://doaj.org/article/17a6c1e0f18841c184e14890ad5fd895
Autor:
Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Masamichi Kimura, Yorimitsu Koshikawa, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Hiroshi Nakase
Publikováno v:
Intestinal Research, Vol 13, Iss 3, Pp 250-258 (2015)
Background/AimsThe long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with
Externí odkaz:
https://doaj.org/article/06131b10447443ad9c848f58a1cdd462
Autor:
Takuya Yoshino, Minoru Matsuura, Naoki Minami, Satoshi Yamada, Yusuke Honzawa, Masamichi Kimura, Yorimitsu Koshikawa, Ali Madian, Takahiko Toyonaga, Hiroshi Nakase
Publikováno v:
Intestinal Research, Vol 13, Iss 3, Pp 266-273 (2015)
Background/AimsEarly use of biologics in patients with Crohn's disease (CD) improves quality of life. However, the effects of the early use of immunomodulators on long-term outcomes remain unclear. This study aimed to evaluate the effects of immunomo
Externí odkaz:
https://doaj.org/article/048f5f37ee504b74b366c78b3a546139
Autor:
Masamichi Kimura, Yoshihisa Tsuji, Masako Iwai, Masahiro Inagaki, Ali Madian, Takuya Yoshino, Minoru Matsuura, Hiroshi Nakase
Publikováno v:
Intestinal Research, Vol 13, Iss 2, Pp 166-169 (2015)
Behçet's disease (BD) is a systemic vasculitis, while myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic disorders characterized by ineffective hematopoiesis. Some studies suggest a relationship between MDS and BD, especia
Externí odkaz:
https://doaj.org/article/c2b12fd9f67e4bed812999d44e47b73f