Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Masamichi, Ohkura"'
Autor:
Khaled Ghandour, Noriaki Ohkawa, Chi Chung Alan Fung, Hirotaka Asai, Yoshito Saitoh, Takashi Takekawa, Reiko Okubo-Suzuki, Shingo Soya, Hirofumi Nishizono, Mina Matsuo, Makoto Osanai, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Yasunori Hayashi, Takeshi Sakurai, Takashi Kitamura, Tomoki Fukai, Kaoru Inokuchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to c
Externí odkaz:
https://doaj.org/article/d96ece91fcd34bc6904590181d831291
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recording the activity of neurons over large brain regions requires expanding the field of view of the optics without losing on spatial and temporal resolution. Here, the authors report a micro-opto-mechanical device that enables two-photon imaging a
Externí odkaz:
https://doaj.org/article/92c101dd3b0d4c3eaa6a3e419950508e
Publikováno v:
Zoological Letters, Vol 4, Iss 1, Pp 1-14 (2018)
Abstract Background Tyramine, known as a “trace amine” in mammals, modulates a wide range of behavior in invertebrates; however, the underlying cellular and circuit mechanisms are not well understood. In the nematode Caenorhabditis elegans (C. el
Externí odkaz:
https://doaj.org/article/bacf19de9b8742bca12e66b1ac519638
Autor:
Mica Ohara-Imaizumi, Kyota Aoyagi, Hajime Yamauchi, Masashi Yoshida, Masayuki X. Mori, Yamato Hida, Ha Nam Tran, Masamichi Ohkura, Manabu Abe, Yoshihiro Akimoto, Yoko Nakamichi, Chiyono Nishiwaki, Hayato Kawakami, Kazuo Hara, Kenji Sakimura, Shinya Nagamatsu, Yasuo Mori, Junichi Nakai, Masafumi Kakei, Toshihisa Ohtsuka
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1213-1226.e7 (2019)
Summary: Pancreatic β cells secrete insulin by Ca2+-triggered exocytosis. However, there is no apparent secretory site similar to the neuronal active zones, and the cellular and molecular localization mechanism underlying polarized exocytosis remain
Externí odkaz:
https://doaj.org/article/5c1ff8df43a5413b832a744435d040af
Autor:
Hiromu Monai, Masamichi Ohkura, Mika Tanaka, Yuki Oe, Ayumu Konno, Hirokazu Hirai, Katsuhiko Mikoshiba, Shigeyoshi Itohara, Junichi Nakai, Youichi Iwai, Hajime Hirase
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
While transcranical direct current stimulation (tDCS) is used in clinical setting, its cellular mechanism of action is unclear. Here, Hajime Hirase and colleagues visualize cellular response in mouse brain to tDCS and show robust astrocyte activation
Externí odkaz:
https://doaj.org/article/ae0783c67e994315983234e3e289a89c
Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion
Publikováno v:
eLife, Vol 6 (2017)
In vivo two-photon calcium imaging currently allows us to observe the activity of multiple neurons up to ~900 µm below the cortical surface without cortical invasion. However, many important brain areas are located deeper than this. Here, we used an
Externí odkaz:
https://doaj.org/article/7c119775041040eab9d82c3e91260034
Autor:
Philipp Bethge, Stefano Carta, Dayra A Lorenzo, Ladan Egolf, Despoina Goniotaki, Linda Madisen, Fabian F Voigt, Jerry L Chen, Bernard Schneider, Masamichi Ohkura, Junichi Nakai, Hongkui Zeng, Adriano Aguzzi, Fritjof Helmchen
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179460 (2017)
Genetically encoded calcium indicators (GECIs) enable imaging of in vivo brain cell activity with high sensitivity and specificity. In contrast to viral infection or in utero electroporation, indicator expression in transgenic reporter lines is induc
Externí odkaz:
https://doaj.org/article/9d5958315bad49cea2046cab5a5cf390
Autor:
Toshio Ohshima, Yasunori Hayashi, Takashi Saito, Junichi Nakai, Tanvir Islam, Takaomi C. Saido, Masaaki Sato, Yukiko Sekine, Masamichi Ohkura, Kotaro Mizuta, Risa Takamura
Publikováno v:
J Neurosci
Impairment of episodic memory, a class of memory for spatiotemporal context of an event, is an early symptom of Alzheimer's disease. Both spatial and temporal information are encoded and represented in the hippocampal neurons, but how these represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcfa7ebd2f40e703699151454694b70
https://doi.org/10.1523/jneurosci.0208-21.2021
https://doi.org/10.1523/jneurosci.0208-21.2021
Autor:
Tsubasa Ito, Midori Kobayashi, Yoshinori Kuroiwa, Masaru Horikoshi, Kenta Kobayashi, Takahiro Ode, Atsushi Miyawaki, Hiroyuki Hioki, Yoshiki Ito, Masamichi Ohkura, Muneki Ikeda, Keisuke Ota, Masafumi Oizumi, Junya Matsushita, Hiroyuki Uwamori, Toru Aonishi, Masanori Murayama, Maya Odagawa, Yasuhiro Oisi, Chie Matsubara, Takayuki Suzuki, Junichi Nakai
Publikováno v:
Neuron. 109(Issue 11):1810-1824
Summary Fast and wide field-of-view imaging with single-cell resolution, high signal-to-noise ratio, and no optical aberrations have the potential to inspire new avenues of investigations in biology. However, such imaging is challenging because of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c87ce652c737a5553739ccb25be3c0
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100849154
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100849154
Autor:
Takashi Takekawa, Masanori Nomoto, Hirotaka Asai, Noriaki Ohkawa, Reiko Okubo-Suzuki, Khaled Ghandour, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Shin-ichi Muramatsu, Yasunori Hayashi, Kaoru Inokuchi, Tomoki Fukai
Currently, calcium imaging allows for the long-term recording of large-scale neuronal activity in diverse states. However, it remains difficult to extract neuronal dynamics from recorded imaging data. In this study, we propose an improved CNMF-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20447df11a6c942bfa01cbed1b88bb62
https://doi.org/10.1101/2022.04.05.487077
https://doi.org/10.1101/2022.04.05.487077
