Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Masami Ukawa"'
Autor:
Yuri Fujioka, Hideto Ueki, Ruhan A, Akari Sasajima, Takumi Tomono, Masami Ukawa, Haruya Yagi, Shinji Sakuma, Koichi Kitagawa, Toshiro Shirakawa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5997 (2024)
Cancer immunotherapy using antigen-pulsed dendritic cells can induce strong cellular immune responses by priming cytotoxic T lymphocytes. In this study, we pulsed tumor cell lysates with VP-R8, a cell-penetrating D-octaarginine-linked co-polymer of N
Externí odkaz:
https://doaj.org/article/8599f8ba7564433c95da9b953185f470
Autor:
Wellington Pham, Shawn Barton, Bo Li, Michael Siuta, Vaibhav A. Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma
Publikováno v:
Precision Nanomedicine, Vol 1, Iss 3 (2018)
The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging probe, the t
Externí odkaz:
https://doaj.org/article/c56a8962414042c48370c70d6d02a06b
Autor:
Haruya Yagi, Takumi Tomono, Yuma Handa, Natsuki Saito, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma
Publikováno v:
Molecular Pharmaceutics. 20:303-313
We have been investigating the potential of cell-penetrating peptides anchored to polymeric platforms as a novel absorption enhancer which delivers biologics into systemic circulation via mucosal routes. Our previous mouse experiments demonstrated th
Autor:
Saki SAKUMA, Mariko OKAMOTO, Nao MATSUSHITA, Masami UKAWA, Takumi TOMONO, Keiko KAWAMOTO, Teruo IKEDA, Shinji SAKUMA
Publikováno v:
Journal of Veterinary Medical Science. 84:484-493
Autor:
Saki, Sakuma, Mariko, Okamoto, Nao, Matsushita, Masami, Ukawa, Takumi, Tomono, Keiko, Kawamoto, Teruo, Ikeda, Shinji, Sakuma
Publikováno v:
The Journal of veterinary medical science. 84(4)
Poly(N-vinylacetamide-co-acrylic acid) coupled with d-octaarginine (VP-R8) promotes the cellular uptake of peptides/proteins in vitro; however, details of the transfection efficacy of VP-R8, such as the cell types possessing high gene transfer, are n
Autor:
Hideo Kobayashi, Etsuo Tobita, Takahiro Miwa, Kohei Miyata, Seiya Ishizaki, Masami Ukawa, Mao Nonomura, Shinji Sakuma, Ryoji Igi, Haruya Yagi, Takumi Tomono, Hironori Kumagai
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 154:186-194
Our previous mouse studies demonstrated that mean bioavailability of exendin-4, which is an injectable glucagon-like peptide-1 (GLP-1) analogue whose molecular weight (Mw) and isoelectric point (pI) are ca. 4.2 kDa and 4.5, respectively, administered
Autor:
Etsuo Tobita, Masanori Baba, Sohei Tanishita, Shinji Sakuma, Masami Ukawa, Kohei Miyata, Takumi Tomono, Takumi Tsujioka, Tomofumi Uto, Yuki Yoshida
Publikováno v:
Bioconjugate Chemistry. 30:3028-3037
Mucosal vaccination, which secretion of immunoglobulin A (IgA) on the mucosa is accompanied by induction of immunoglobulin G (IgG) in the blood, is one of the most effective ways to circumvent influenza epidemics caused by incorrect prediction of epi
Autor:
Masami Ukawa
Publikováno v:
Drug Delivery System. 37:272-273
Autor:
Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
Publikováno v:
International journal of pharmaceutics. 613
We have developed an aggregate of D-octaarginine immobilized at multiple points on a co-polymer of N-vinylacetamide and acrylic acid. Previous studies revealed that immunoglobulin G and A were induced when mice were inoculated with influenza virus an
Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues
Autor:
Takumi Tomono, Etsuo Tobita, Hironori Kumagai, Kanako Nakai, Minoru Matsuura, Kosuke Yamada, Hiroshi Nakase, Kohta Mohri, Takaaki Eguchi, Takuya Yoshino, Masami Ukawa, Shinji Sakuma, Wellington Pham, Tokio Kitamura, Testuya Yoshizaki, Takumi Fukuchi
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 136:29-37
We are investigating an imaging agent for early detection of colorectal cancer. The agent, named the nanobeacon, is coumarin 6-encapsulated polystyrene nanospheres whose surfaces are covered with poly(N-vinylacetamide) and peanut agglutinin that redu