Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Masami Miyamoto"'
Publikováno v:
Journal of Japan Academy of Nursing Science. 29:50-55
Autor:
Isabelle Stücker, Noritaka Ariyoshi, Masami Miyamoto, Tetsuya Kamataki, Marie-Anne Loriot, Sylvie Cénée, Sandra Rebuissou, Mikael Oscarson, Denis Hémon, Philippe Beaune
Publikováno v:
Pharmacogenetics. 11:39-44
Cytochrome P450 2A6 (CYP2A6) is involved in the C-oxidation of nicotine and in the metabolic activation of tobacco nitrosamines. Recent data have suggested that CYP2A6 genetic polymorphisms might play a role in tobacco dependence and consumption as w
Autor:
Yuki Takahashi, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu, Satoshi Daigo, Noritaka Ariyoshi, Philippe Beaune, Tetsuya Kamataki, Tsuyoshi Yokoi, Ken-ichi Nunoya
Publikováno v:
Drug Metabolism and Pharmacokinetics. 15:57-61
CYP2A6 has been characterized as a coumarin 7-hydroxylase in humans. A large interindividual difference in the activity of coumarin 7-hydroxylation suggested an existence of genetic polymorphism of this enzyme. In fact, CYP2A6*2 variant allele which
Autor:
Masami Miyamoto
Publikováno v:
HISPANICA / HISPÁNICA. 1992:105-119
Autor:
Hideo Kunitoh, Masami Miyamoto, Jun Yokota, Nobuo Nemoto, Noritaka Ariyoshi, Hirotoshi Dosaka-Akita, Kunio Sato, Yuichi Sawamura, Yuri Umetsu, Tetsuya Kamataki
Publikováno v:
Biochemical and Biophysical Research Communications. 261:658-660
CYP2A6 is an enzyme with a high ability to activate a nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to its potent and ultimate carcinogen. In the present study, we investigated the relationship between genetic polymorphism of CYP
Autor:
Noritaka, Ariyoshi, Masami, Miyamoto, Yuri, Umetsu, Hideo, Kunitoh, Hirotoshi, Dosaka-Akita, Yu-Ichi, Sawamura, Jun, Yokota, Nobuo, Nemoto, Kunio, Sato, Tetsuya, Kamataki
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 11(9)
Cytochrome P450 2A6 (CYP2A6) is the principal enzyme involved in the metabolic activation of tobacco-specific nitrosamines to their ultimate carcinogenic forms and metabolism of nicotine. We investigated the effects of the CYP2A6*4, an entire CYP2A6
Autor:
Yoshiyuki Yamazaki, Ken-ichi Fujita, Tetsuya Kamataki, Noritaka Ariyoshi, Kazuo Nakayama, Masami Miyamoto
Publikováno v:
Drug metabolism reviews. 34(3)
The role of human cytochrome P450 (CYP) in the metabolic activation of tobacco-related N-nitrosamines was examined by Salmonella mutation test using a series of genetically engineered Salmonella typhimurium YG7108 strains each co-expressing a form of
Autor:
Tomonori Tateishi, Masami Miyamoto, Moritoshi Kinoshita, Isabelle Stücker, Yoshihiro Mizorogi, Tetsuya Kamataki, Yuki Takahashi, Shinichi Kobayashi, Marie-Anne Loriot, Noritaka Ariyoshi, Satoshi Daigo, Yuri Umetsu, Philippe Beaune
Publikováno v:
Pharmacogenetics. 10(8)
During the course of investigating the frequency of a CYP2A6 whole deletion-type polymorphism (CYP2A6 * 4C) in Japanese, an unexpectedly large population of heterozygotes for CYP2A6 * 4C and the wild-type (CYP2A6 * 1A) was found. Cloning of a cDNA en
Autor:
Jun-Tack Kwon, Fred F. Kadlubar, Philippe Beaune, Yuki Takahashi, Tetsuya Kamataki, Satoshi Daigo, Rashimi Shinha, Noritaka Ariyoshi, Tsuyoshi Yokoi, Ken-ichi Nunoya, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:100-101
CYP2A6 is known as an enzyme responsible for the metabolism of coumarin. As its toxicological significance, aflatoxin B1 and NNK are metabolically activated by this CYP to mutagens. In our recent studies, we found that a newly developed drug, SM-1250