Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Masami Masuda-Suzukake"'
Autor:
Shiori Awa, Genjiro Suzuki, Masami Masuda-Suzukake, Takashi Nonaka, Minoru Saito, Masato Hasegawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Accumulation of phosphorylated α-synuclein aggregates has been implicated in several diseases, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and is thought to spread in a prion-like manner. Elucidating the mechanisms
Externí odkaz:
https://doaj.org/article/3ea9c0290fc6461ebe5edf9ab1de5edf
Autor:
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cereb
Externí odkaz:
https://doaj.org/article/bb04ab8adf9d41ed8dc3cbb1e5c3ee4c
Autor:
Isabelle Lavenir, Daniela Passarella, Masami Masuda-Suzukake, Annabelle Curry, Janice L. Holton, Bernardino Ghetti, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Synucleinopathies [Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous α-synuclein assemblies in nerve cells and glial cells. We compared the abilities of brain extracts from MSA
Externí odkaz:
https://doaj.org/article/f2e2357037754171bea60e9a5183766a
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200763 (2018)
Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. It has previously been shown that alpha-synuclein is a substra
Externí odkaz:
https://doaj.org/article/0448ba0d1490483ea32b72b028dec65e
Autor:
Takashi Nonaka, Masami Masuda-Suzukake, Tetsuaki Arai, Yoko Hasegawa, Hiroyasu Akatsu, Tomokazu Obi, Mari Yoshida, Shigeo Murayama, David M.A. Mann, Haruhiko Akiyama, Masato Hasegawa
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 124-134 (2013)
TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS). Here, we report the characterization of prion-like properties of ag
Externí odkaz:
https://doaj.org/article/7a1050a8368944ce822e6c1591c16f3e
Autor:
Masato Hosokawa, Tetsuaki Arai, Masami Masuda-Suzukake, Takashi Nonaka, Makiko Yamashita, Haruhiko Akiyama, Masato Hasegawa
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52389 (2012)
In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggre
Externí odkaz:
https://doaj.org/article/89ea75920ebc412aba8bcf1565ed51e7
Autor:
Genjiro Suzuki, Hiroshi Shitara, Tetsuaki Arai, Masato Hasegawa, Aki Shimozawa, Hiromi Kondo, Masato Hosokawa, William Campbell, Masami Masuda-Suzukake, Takashi Nonaka
Publikováno v:
Brain. 145:349-361
The phenomenon of ‘prion-like propagation’ in which aggregates of abnormal amyloid-fibrilized protein propagate between neurons and spread pathology, is attracting attention as a new mechanism in neurodegenerative diseases. There is a strong corr
Autor:
Masami Masuda-Suzukake, Michel Goedert, Daniela Passarella, Isabelle Lavenir, Dennis W. Dickson, Sophie A. Morgan, X. Bernardino Ghetti, Michael DeTure, Juan Fan
Publikováno v:
The Journal of Biological Chemistry
Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient cent
Autor:
Janice L. Holton, Zane Jaunmuktane, John L Chen, Thomas T. Warner, Masami Masuda-Suzukake, Michel Goedert, Annabelle Grossman, Richard Berks, Manuel Schweighauser, Isabelle Lavenir, Jennifer A. Macdonald
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86869e0e4249259b4e469687b4f3482
https://www.repository.cam.ac.uk/handle/1810/331029
https://www.repository.cam.ac.uk/handle/1810/331029
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2322
The propagation of assembled α-synuclein (αS) is key to understanding the pathological mechanisms of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Here we describe a nonhuman primate model of