Výsledky vyhledávání - "Masami Hirota"

Data from Ckap2 Regulates Aneuploidy, Cell Cycling, and Cell Death in a p53-Dependent Manner

Autor: Tak Wah Mak, Samuel Benchimol, Christopher D. Richardson, Robert Rottapel, Marees Harris-Brandts, Annick Itie-YouTen, Alexandra Ho, Kathrin Zaugg, Masami Hirota-Tsuchihara, Lauren Brown, Hitoshi Okada, Christopher Bakal, Valentina Lapin, Katsuya Tsuchihara

We used DNA microarray screening to identify Ckap2 (cytoskeleton associated protein 2) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0e1daa8971436483fc28863c43c00e
https://doi.org/10.1158/0008-5472.c.6493653.v1

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Ckap2 Regulates Aneuploidy, Cell Cycling, and Cell Death in a p53-Dependent Manner

Autor: Annick Itie-Youten, Marees Harris-Brandts, Valentina Lapin, Katsuya Tsuchihara, Masami Hirota-Tsuchihara, Kathrin Zaugg, Lauren E. Brown, Tak W. Mak, Samuel Benchimol, Alexandra Ho, Hitoshi Okada, Chris Bakal, Robert Rottapel, Christopher D. Richardson

Publikováno v: Cancer Research. 65:6685-6691

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9affe5f98d757836f9e087db21bc0ace
https://doi.org/10.1158/0008-5472.can-04-4223

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Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers

Autor: Jürgen Ruland, Norman M. Kneteman, Masami Hirota-Tsuchihara, Jingyu Diao, D. Lorne Tyrrell, Cathy Iorio, Giovanni Migliaccio, Farida Sarangi, Christopher D. Richardson, Eric Hsu, Belinda Hsi

Publikováno v: Nature Biotechnology. 21:519-525

Hepatitis C virus (HCV) encodes a polyprotein consisting of core, envelope (E1, E2, p7), and nonstructural polypeptides (NS2, NS3, NS4A, NS4B, NS5A, NS5B). The serine protease (NS3/NS4A), helicase (NS3), and polymerase (NS5B) constitute valid targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec9501d5064ca1bc2d393e94ab4ec8a
https://doi.org/10.1038/nbt817

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HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

Autor: Shoji Yamaoka, Kunitada Shimotohno, Masami Hirota, Osamu Masui, Yoichi Taya, Yasuo Ariumi, Atsushi Kaida, Jye Yee Lin

Publikováno v: Oncogene. 19:1491-1499

The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein repressed the transcriptional activity of wild-type p53 through its N-terminal trans-activation domain. Although Tax did not directly bind to p53, this repression required the activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9b05549a2dfb95db110b838322d04a
https://doi.org/10.1038/sj.onc.1203450

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Studies on rat hepatic hydroxysteroid sulfotransferase — immunochemistry, development and pI variants

Autor: Mie Takahashi, Minoru Kamakura, Hiroshi Homma, Michio Matsui, Masami Hirota, Izumi Nakagome

Publikováno v: Chemico-Biological Interactions. 92:15-24

Rat hepatic hydroxysteroid sulfotransferase with sulfoconjugates androsterone (androsterone-sulfating sulfotransferase) is an oligomer consisting of several subunits with distinct pI values but with the same molecular mass (pI variants). N-terminal a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b2fe7b4602ee55c6ec86cafdab19e
https://doi.org/10.1016/0009-2797(94)90049-3

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[A case of fluvoxamine overdose]

Autor: Hiroyasu, Oka, Yoichi, Shirakawa, Kazuhiro, Koyama, Soichi, Maekawa, Masami, Hirota, Osamu, Nishizaki, Shinya, Fukumoto, Genro, Ochi

Publikováno v: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 15(1)

Selective serotonin reuptake inhibitors (SSRI) are newly developed-antidepressants authorized in 1999 in Japan. We experienced a case of drug poisoning including fluvoxamine, one of SSRI. A comatose nineteen-year-old girl was transported to our ER in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99cd350b45e720a87bb6c047a3bc3b8c
https://pubmed.ncbi.nlm.nih.gov/11977737

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Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation

Autor: Nobuyuki Kato, Masami Hirota, Makoto Hijikata, Kunitada Shimotohno, Shin Ichi Asabe, Shinya Satoh, Michinori Kohara, Kyoko Tsukiyama-Kohara

Publikováno v: Virology. 257(1)

We previously showed that two proteins with molecular weights of 56 and 58 kDa are produced from nonstructural protein 5A (NS5A) derived from hepatitis C virus (HCV)-1b genotype. The 56-kDa protein is phosphorylated at serine residues in NS5A, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da6faa976f22b5cc6efafb33db72327
https://pubmed.ncbi.nlm.nih.gov/10208927

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Site-directed mutagenesis of rat hepatic hydroxysteroid sulfotransferases

Autor: Kazuaki Ogawa, Masami Hirota, Michio Matsui, Keiko Hirono, Isamu Tanahashi, Yoriko Morioka, Hiroshi Homma

Publikováno v: Biochimica et biophysica acta. 1296(2)

Two cDNA clones of rat hepatic hydroxysteroid sulfotransferase (ST) (ST-40 and ST-20) were isolated and expressed in Escherichia coli cells. Several histidine residues in their coding regions are highly conserved in the ST superfamily, and histidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547f05fc50e97e01cdf5a6aa4b6dc658
https://pubmed.ncbi.nlm.nih.gov/8814222

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