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Anhedonia, depression, anxiety, and craving in opiate dependent patients stabilized on oral naltrexone or an extended release naltrexone implant

Autor: E. Verbitskaya, Anna Pecoraro, Marina Tsoy-Podosenin, Masalov Dv, Natalia Bushara, Evgeny Krupitsky, Valentina Wahlgren, Edwin Zvartau, Romanova Tn, Elena Blokhina, Burakov Am, T Yaroslavtseva, Vladimir Palatkin, George E. Woody, Arina Tyurina

Publikováno v: The American Journal of Drug and Alcohol Abuse. 42:614-620

Naltrexone is a μ-opioid receptor antagonist that blocks opioid effects. Craving, depression, anxiety, and anhedonia are common among opioid dependent individuals and concerns have been raised that naltrexone increases them due to blocking endogenou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c5dd4a623ba872fd705a75a38e1c9d
https://doi.org/10.1080/00952990.2016.1197231

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[Anhedonia, depression, anxiety, and craving in opioid dependent patients stabilized on oral naltrexone or naltrexone implant]

Autor: Anna Pecoraro, Marina Tsoy-Podosenin, E. Verbitskaya, Tiurina Aa, Evgeny Krupitsky, Sulimov Gy, N. Bushara, Valentina Wahlgren, Edwin Zvartau, Masalov Dv, Elena Blokhina, T Yaroslavtseva, George E. Woody, Romanova Tn, Burakov Am, Vladimir Palatkin

Publikováno v: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 118(1. Vyp. 2)

To assess the relationship between long-term naltrexone treatment and anxiety, depression and craving in opioid dependent individuals.Opioid dependent patients (n=306) were enrolled in a three cell (102ss/cell) randomized, double blind, double dummy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd2862fe002a013eb0a775192962028
https://pubmed.ncbi.nlm.nih.gov/29658501

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Slow Release Naltrexone Implant vs Oral Naltrexone for Improving Treatment Outcomes in Opioid Addicted Participants with HIV: A Randomised Trial

Autor: Daniel D. Langleben, Masalov Dv, Robert E. Gross, Evgeny Krupitsky, E. Verbitskaya, Edwin Zvartau, Sabrina Poole, Natalia Bushara, M. Vetrova, T Yaroslavtseva, Olga Mamontova, Dmitry Lioznov, Burakov Am, Vladimir Palatkin, Elena Blokhina, George E. Woody

Publikováno v: SSRN Electronic Journal.

Background: Untreated opioid addiction in persons with HIV is associated with poor outcome. Agonist maintenance is not always available and some do not want it. Slow release naltrexone may be a useful option. Methods: The study was a 48-week trial in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11524a71c74835cb1124262b6aa663ef
https://doi.org/10.2139/ssrn.3273169

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[Stabilization of remission in patients with opioid dependence with naltrexone implant: a pharmacogenetic approach]

Autor: Е М Krupitsky, Т Kosten, Edwin Zvartau, Т S Yaroslavtseva, G Yu Sulimov, Е V Verbitskaya, Е А Blokhina, D Woody, David A. Nielsen, Т N Romanova, А М Burakov, V М Brodyansky, Natalia Bushara, N P Alekseeva, А О Kibitov, Masalov Dv, V.Ya. Palatkin

Publikováno v: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 115(4 Pt 2)

To evaluate the effect of opioid receptor genes and dopamine system genes polymorphisms on treatment outcomes of opioid dependence with implantable and oral naltrexone.Authors carried out a randomized double-blind, double-dummy, placebo-controlled cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2febeff504989ae68fde6c2f0d84cf53
https://pubmed.ncbi.nlm.nih.gov/26288297

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A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine

Autor: Т Kosten, Т N Romanova, Е М Krupitsky, Edwin Zvartau, Natalia Bushara, Masalov Dv, А М Burakov, David A. Nielsen, V М Brodyansky, N P Alekseeva, Е V Verbitskaya, G Yu Sulimov, Т S Yaroslavtseva, А О Kibitov, A Yа Grinenko, Е А Blokhina, V Yа Palatkin

Publikováno v: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 116:36

To evaluate an effect of opioid receptor and dopamine system gene polymorphisms on the efficacy of combined treatment with oral naltrexone and guanfacine in a randomized double blinded double dummy placebo controlled clinical trial.Three hundred and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8125f582a995deac5da047a0c9d4920d
https://doi.org/10.17116/jnevro201611611236-48

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A double-blind randomized placebo-controlled study of the efficacy of the combined treatment with naltrexone and guanfacine for relapse prevention in opiate dependence

Autor: Tiurina Aa, Grininko Ay, Edwin Zvartau, Evgeny Krupitsky, Bushara Em, Burakov Am, Vladimir Palatkin, Elena Blokhina, Rajita Sinha, Thomas R. Kosten, T Yaroslavtseva, Masalov Dv, Verbitskaya Ve, Romanova Tn

Publikováno v: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 115:39

Authors studied the effect of α-2-adrenoreceptor agonist guanfacine on replace prevention in opiate addicts.Three hundred and one recently detoxified opiate addicts were randomized under the double-blind double-dummy conditions into one of four trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411d17a3164d18754cf2a2892a693d4d
https://doi.org/10.17116/jnevro201511510139-46

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Prevention of suicide by naltrexone in a recently detoxified heroin addict

Autor: Edwin Zvartau, Evgeny Krupitsky, Romanova Tn, Masalov Dv, Burakov Am, T. Y. Didenko, George E. Woody

Publikováno v: European addiction research. 7(2)

This case describes a heroin addict who was participating in a placebo-controlled randomized trial of naltrexone as an aid to relapse prevention. The patient tried to commit suicide by taking a heroin overdose after learning that he was HIV-positive.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad25593425772fc07e7d30c55805e59
https://pubmed.ncbi.nlm.nih.gov/11455175

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Randomized Trial of Long-Acting Sustained-Release Naltrexone Implant vs Oral Naltrexone or Placebo for Preventing Relapse to Opioid Dependence

Autor: Marina Tsoy-Podosenin, Masalov Dv, Evgeny Krupitsky, T. Y. Slavina, Anna Pecoraro, Natalia Bushara, Burakov Am, Vladimir Palatkin, Edwin Zvartau, Valentina Wahlgren, Elena Blokhina, George E. Woody, Arina Tyurina, E. Verbitskaya, Romanova Tn

Publikováno v: Archives of General Psychiatry. 69:973

CONTEXT Sustained-release naltrexone implants may improve outcomes of nonagonist treatment of opioid addiction. OBJECTIVE To compare outcomes of naltrexone implants, oral naltrexone hydrochloride, and nonmedication treatment. DESIGN Six-month double-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1676e5ff5faca336100296c42e179dcb
https://doi.org/10.1001/archgenpsychiatry.2012.1a

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