De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.

Autor: Masalmeh RHA; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Taglini F; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Rubio-Ramon C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Musialik KI; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Higham J; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Davidson-Smith H; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Kafetzopoulos I; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Pawlicka KP; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Finan HM; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Clark R; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK., Wills J; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Finch AJ; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK., Sproul D; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK. Duncan.Sproul@igmm.ed.ac.uk.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK. Duncan.Sproul@igmm.ed.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 694. Date of Electronic Publication: 2021 Jan 29.

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m⁶A modification of ATG4a to promote NPCs senescence and IVDD progression.

Autor: Wu, Ouqiang, Jin, Yuxin, Zhang, Zhiguang, Zhou, Hao, Xu, Wenbin, Chen, Linjie, Jones, Morgan, Kwan, Kenny Yat Hong, Gao, Jianyuan, Zhang, Kai, Cheng, Xiaofei, Chen, Qizhu, Wang, Xinzhou, Li, Yan Michael, Guo, Zhenyu, Sun, Jing, Chen, Zhihua, Wang, Bin, Wang, Xiangyang, Shen, Shuying

Publikováno v: Bone Research; 11/21/2024, Vol. 12 Issue 1, p1-18, 18p

MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis.

Autor: Shin, Yonghwan, Kim, Sungmin, Liang, Gangning, An, Woojin

Publikováno v: Molecular Oncology; Aug2024, Vol. 18 Issue 8, p2001-2019, 19p

H3K36 trimethylation-mediated biological functions in cancer.

Autor: Xiao, Chu¹ (AUTHOR), Fan, Tao¹ (AUTHOR), Tian, He¹ (AUTHOR), Zheng, Yujia¹ (AUTHOR), Zhou, Zheng¹ (AUTHOR), Li, Shuofeng² (AUTHOR), Li, Chunxiang¹ (AUTHOR) lichunxiang@cicams.ac.cn, He, Jie¹ (AUTHOR) prof.jiehe@gmail.com

Publikováno v: Clinical Epigenetics. 10/29/2021, Vol. 13 Issue 1, p1-19. 19p.

DNMT3B PWWP mutations cause hypermethylation of heterochromatin.

Autor: Taglini F; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Kafetzopoulos I; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Altos Labs, Cambridge Institute, Cambridge, UK., Rolls W; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Musialik KI; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; MRC London Institute of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK., Lee HY; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Endocrine Oncology Research Group, Department of Surgery, The Royal College of Surgeons RCSI, University of Medicine and Health Sciences, Dublin, Ireland., Zhang Y; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Marenda M; IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy., Kerr L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK., Finan H; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Swiss Federal Institute of Technology, ETH Zürich, Institute of Molecular Health Sciences, Zürich, Switzerland., Rubio-Ramon C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France., Gautier P; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wapenaar H; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Kumar D; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Davidson-Smith H; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wills J; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Murphy LC; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wheeler A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wilson MD; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. Marcus.Wilson@ed.ac.uk., Sproul D; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. d.sproul@ed.ac.uk.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. d.sproul@ed.ac.uk.

Publikováno v: EMBO reports [EMBO Rep] 2024 Mar; Vol. 25 (3), pp. 1130-1155. Date of Electronic Publication: 2024 Jan 30.