Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Masako Muguruma"'
Autor:
Masako, Muguruma, Mariko, Asaoka, Saeko, Teraoka, Kana, Miyahara, Takahiko, Kawate, Takashi, Ishikawa
Publikováno v:
Anticancer Research. 42:4735-4742
We previously reported that the half maximal inhibitory concentration (ICWe investigated the expression levels of β-tubulin isoforms by real-time polymerase chain reaction and morphology of spheroid formation in the 13 TNBC cell lines cultured using
Autor:
Miki Okazaki, Masako Muguruma, Takako Komiya, Kana Miyahara, Takahiko Kawate, Ai Ueda, Saeko Teraoka, Mariko Asaoka, Eiichi Sato, Hajime Matsumura, Takashi Ishikawa
Publikováno v:
Breast Cancer. 29:343-351
Capsular contracture is the most common complication with smooth-type silicone implants. We investigated the preventive effect of an active metabolite of tamoxifen, 4-hydroxytamoxifen (4-OH TAM), on capsular contracture.A silicone sheet was implanted
Autor:
Masako Muguruma, Masahiko Kuroda, Kana Miyahara, Miki Okazaki, Saeko Teraoka, Mariko Asaoka, Ai Ueda, Takahiko Kawate, Takashi Ishikawa, Yohei Miyagi
Publikováno v:
Biochemical and Biophysical Research Communications. 533:268-274
Three-dimensional (3D) culture reflects tumor biology complexities compared with two-dimensional (2D) culture. Thus, 3D culture has attracted attention in cell biology studies including drug sensitivity tests. Herein, we investigated differences in a
Autor:
Takahiko Kawate, Kana Miyahara, Keisuke Miyazawa, Saeko Teraoka, Naoharu Takano, Takashi Ishikawa, Kimito Yamada, Hiroshi Kaise, Masako Muguruma
Publikováno v:
The Journal of surgical research. 250
Background Many triple-negative breast cancers (TNBCs) show impaired breast cancer susceptibility gene I (BRCA1) function, called BRCAness. BRCAness tumors may show similar sensitivities to anticancer drugs as tumors with BRCA1 mutations. In this stu
Publikováno v:
Cancer Research. 80:326-326
[BACKGROUND] In vitro chemosensitivity tests are not always consistent to clinical results (Hutchinston L et al., Nat Rev Clin Oncol. 2011), partly because of lacking extracellular matrix-cell interactions in 2-dimensional (2D) cell culture system (A
Autor:
Yukie Saegusa, Meilan Jin, Masako Muguruma, Kunitoshi Mitsumori, Toshiya Okamura, Takashi Umemura, Jihei Nishimura, Masako Tasaki, Yasuaki Dewa
Publikováno v:
Toxicology. 244:179-189
The tumour-promoting effects of beta-naphthoflavone (BNF), a novel aryl hydrocarbon receptor (AhR) agonist, were investigated using a medium-term hepatocarcinogenesis model in rats. Six-week-old male F344 rats received an intraperitoneal injection of
Autor:
Masako Muguruma, Masayoshi Takabatake, Yasuaki Dewa, Makoto Shibutani, Yuji Murata, Jihei Nishimura, Kunitoshi Mitsumori, Hironobu Yasuno
Publikováno v:
The Journal of Toxicological Sciences. 33:197-207
To examine the possible modifying effect of the extract of Siraitia grosvenori (SGE), a naturally occurring antioxidative agent, on piperonyl butoxide (PBO)-promoted hepatocarcinogenesis, male F344 rats were administered a single intraperitoneal inje
Autor:
Yasuaki Dewa, Taichi Kono, Meilan Jin, Masayoshi Takabatake, Makoto Shibutani, Kunitoshi Mitsumori, Masako Muguruma, Jihei Nishimura, Hironobu Yasuno
Publikováno v:
The Journal of Toxicological Sciences. 33:127-140
We previously found that administration of ascorbic acid (AA) enhances the liver tumor-promoting activity of kojic acid (KA) in mice. To examine the reproducibility of these results in rats and the underlying mechanism of this effect, we employed a t
Autor:
Meilan Jin, Mitsuyoshi Moto, Yoko Kashida, Miwa Okamura, Masako Muguruma, Kunitoshi Mitsumori
Publikováno v:
Food and Chemical Toxicology. 45:1231-1237
Siraitia grosvenori extract has been used as a food additive. As a part of the safety assessment of the extracts, a 13-week repeated dose toxicity study was performed in Wistar Hannover (GALAS) rats. Male and female rats were divided into five groups
Autor:
Keiji Hasumi, Kazumi Ito, Miwa Takahashi, Masako Muguruma, Kyoko Watanabe, Kunitoshi Mitsumori, Mitsuyoshi Moto, Taichi Kono, Yusuke Kenmochi, Meilan Jin
Publikováno v:
Archives of Toxicology. 81:883-894
To evaluate the carcinogenicity of troglitazone in rasH2 mice, 7-week-old male and female rasH2 mice were fed a diet containing 0, 3,000 or 6,000 ppm troglitazone for 26 weeks. An increased tendency in the incidence of vascular tumors was observed in