Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Masakiyo Sasahara"'
Autor:
Tsutomu Wada, Yuki Takeda, Akira Okekawa, Go Komatsu, Yuichi Iwasa, Yasuhiro Onogi, Ichiro Takasaki, Takeru Hamashima, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The platelet-derived growth factor (PDGF) family contributes to the progression of steatohepatitis; however, changes in and the characteristics of isoform-specific expression remain unclear. Since diabetes is a major driver of metabolic dysf
Externí odkaz:
https://doaj.org/article/9ad6bd0aed7a48259c8e1cabd12831d3
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Autor:
Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-15 (2024)
Abstract Background Pericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and en
Externí odkaz:
https://doaj.org/article/6a4c91fa21f741f8a3a01872afe49b70
Autor:
Allah Nawaz, Muhammad Bilal, Shiho Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, Koichi Tsuneyama, Ayumi Nishimura, Yasuhiro Nishida, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Hisashi Mori, Martin M. Matzuk, Fujimi Kudo, Ichiro Manabe, Akiyoshi Uezumi, Takashi Nakagawa, Yumiko Oishi, Kazuyuki Tobe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Muscle regeneration requires the contribution and communication of various different cell types. Here, Nawaz et al. show that CD206+ macrophages inhibit the secretion of the promyogenic factor follistatin by fibro-adipogenic progenitor cells, impedin
Externí odkaz:
https://doaj.org/article/940fc3d0e8834f71b70e400aa3500e3a
Autor:
Yasuhiro Nishida, Allah Nawaz, Tomonobu Kado, Akiko Takikawa, Yoshiko Igarashi, Yasuhiro Onogi, Tsutomu Wada, Toshiyasu Sasaoka, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Kumpei Tokuyama, Isao Usui, Takashi Nakagawa, Shiho Fujisaka, Yagi Kunimasa, Kazuyuki Tobe
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 241-258 (2020)
Abstract Background Skeletal muscle is mainly responsible for insulin‐stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), a natural antioxidant, h
Externí odkaz:
https://doaj.org/article/9494eddd07ec4af58e146f3efc1562e2
Autor:
Masashi Morita, Ai Toida, Yuki Horiuchi, Shiro Watanabe, Masakiyo Sasahara, Kosuke Kawaguchi, Takanori So, Tsuneo Imanaka
Publikováno v:
Heliyon, Vol 7, Iss 2, Pp e06228- (2021)
X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disease characterized by inflammatory demyelination, and activated astrocytes as well as microglia are thought to be involved in its pathogenesis. Conditionally immortalized astrocytic c
Externí odkaz:
https://doaj.org/article/d5d7697e14d54526a4f642e03ac52f4e
Autor:
Takahide Kuwano, Hironori Izumi, Muhammad Rahil Aslam, Yoshiko Igarashi, Muhammad Bilal, Ayumi Nishimura, Yoshiyuki Watanabe, Allah Nawaz, Tomonobu Kado, Koichi Ikuta, Seiji Yamamoto, Masakiyo Sasahara, Shiho Fujisaka, Kunimasa Yagi, Hisashi Mori, Kazuyuki Tobe
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248267 (2021)
Meflin (Islr) expression has gained attention as a marker for mesenchymal stem cells, but its function remains largely unexplored. Here, we report the generation of Meflin-CreERT2 mice with CreERT2 inserted under the Meflin gene promoter to label Mef
Externí odkaz:
https://doaj.org/article/21c085d407024df5a22ce3b5bee77b7b
Autor:
Hiromasa Takakura, Takeru Hamashima, Hirohiko Tachino, Akira Nakazato, Hiroshi Minato, Masakiyo Sasahara, Hideo Shojaku
Publikováno v:
Frontiers in Surgery, Vol 7 (2020)
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm of the nasopharynx. Accordingly, its clinical and pathological characteristics are not well-known. We report a case of TL-LGNPPA and review the r
Externí odkaz:
https://doaj.org/article/48cd3ec27344421d962cf06aa7b1fa03
Publikováno v:
Frontiers in Neural Circuits, Vol 14 (2020)
To understand functional neuronal circuits for emotion in the basal forebrain, patterns of neuronal activation were examined in mice by immunohistochemistry of immediate-early gene products (Zif268/Egr1 and c-Fos). In all mice examined, clusters of 3
Externí odkaz:
https://doaj.org/article/bb6cb0f96742459f9dab0cf64ac53d50
Autor:
Kohta Yamada, Takeru Hamashima, Yoko Ishii, Seiji Yamamoto, Noriko Okuno, Naofumi Yoshida, Moe Yamada, Ting Ting Huang, Norifumi Shioda, Kei Tomihara, Toshihiko Fujimori, Hisashi Mori, Kohji Fukunaga, Makoto Noguchi, Masakiyo Sasahara
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1461-1479 (2018)
Background/Aims: The migration of mesenchymal cells is a fundamental cellular process that has been implicated in many pathophysiological conditions and is induced by chemoattractants such as platelet-derived growth factors (PDGFs). However, the regu
Externí odkaz:
https://doaj.org/article/3d465d4d15984092acd4962982f84de8
Autor:
Hideyuki Kitahara, Sayaka Kajikawa, Yoko Ishii, Seiji Yamamoto, Takeru Hamashima, Erika Azuma, Hikari Sato, Takako Matsushima, Masabumi Shibuya, Yutaka Shimada, Masakiyo Sasahara
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 190-201 (2018)
Pericyte desorption from retinal blood vessels and subsequent vascular abnormalities are the pathogenesis of diabetic retinopathy (DR). Although the involvement of abnormal signals including platelet-derived growth factor receptor-β (PDGFRβ) and va
Externí odkaz:
https://doaj.org/article/b1b42ff4e43744cabfe57d68fdc1b0be