Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Masaki Okumura"'
Autor:
Kenta Arai, Masaki Okumura, Young-Ho Lee, Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, Kenji Inaba, Michio Iwaoka
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological
Externí odkaz:
https://doaj.org/article/3b226a8eb62b476ba0aaef9ad91a6b1c
Publikováno v:
Biophysics and Physicobiology, Vol 19 (2022)
Externí odkaz:
https://doaj.org/article/545a6aa8d14b43a794f3e73875a01f7f
Autor:
Yoko Suzuki, Miho Miyajima, Katsuya Ohta, Noriko Yoshida, Takafumi Watanabe, Mayo Fujiwara, Masaki Okumura, Mitsuru Nakamura, Tetsuo Sasano, Tokuhiro Kawara, Masato Matsuura, Eisuke Matsushima
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 1, Pp 2-9 (2019)
Abstract Aim Although electroencephalogram (EEG) seizure duration and seizure threshold change during a course of electroconvulsive therapy, the mechanisms by which these factors influence heart rate during subsequent electroconvulsive therapy sessio
Externí odkaz:
https://doaj.org/article/6aceac1afa40485e8b367d2f10f48527
Autor:
Chihiro Hirayama, Kodai Machida, Kentaro Noi, Tadayoshi Murakawa, Masaki Okumura, Teru Ogura, Hiroaki Imataka, Kenji Inaba
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102296- (2021)
Summary: The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis. Herein, we developed an in vitro system for directly monitoring PDI- or ERp46-catalyzed
Externí odkaz:
https://doaj.org/article/c7807790b9404aa6b960ab9790f2bca1
Autor:
Satoshi Ninagawa, Seiichiro Tada, Masaki Okumura, Kenta Inoguchi, Misaki Kinoshita, Shingo Kanemura, Koshi Imami, Hajime Umezawa, Tokiro Ishikawa, Robert B Mackin, Seiji Torii, Yasushi Ishihama, Kenji Inaba, Takayuki Anazawa, Takahiko Nagamine, Kazutoshi Mori
Publikováno v:
eLife, Vol 9 (2020)
Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance. Olanzapine is particularl
Externí odkaz:
https://doaj.org/article/98ac694ed74149188378b17d0d4cb89b
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 1192-1199 (2018)
Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic gra
Externí odkaz:
https://doaj.org/article/6f912bbf4e27445caabbd8ac17e11d45
Autor:
Motonori Matsusaki, Rina Okada, Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Mai Watabe, Hiroshi Yamaguchi, Tomohide Saio, Young-Ho Lee, Kenji Inaba, Masaki Okumura
Publikováno v:
Biology, Vol 10, Iss 11, p 1112 (2021)
P5 is one of protein disulfide isomerase family proteins (PDIs) involved in endoplasmic reticulum (ER) protein quality control that assists oxidative folding, inhibits protein aggregation, and regulates the unfolded protein response. P5 reportedly in
Externí odkaz:
https://doaj.org/article/45ecc0f3a89d47ea96fcc3025c60da76
Autor:
Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Motonori Matsusaki, Kimiko Kuroki, Hiroshi Yamaguchi, Katsumi Maenaka, Young-Ho Lee, Kenji Inaba, Masaki Okumura
Publikováno v:
Molecules, Vol 26, Iss 10, p 2853 (2021)
ERp57, a member of the protein disulfide isomerase family, is a ubiquitous disulfide catalyst that functions in the oxidative folding of various clients in the mammalian endoplasmic reticulum (ER). In concert with ER lectin-like chaperones calnexin a
Externí odkaz:
https://doaj.org/article/b328a3b2ab504ed68bb56b8aa12976b2
Publikováno v:
Molecules, Vol 26, Iss 4, p 879 (2021)
Oxidative protein folding is a biological process to obtain a native conformation of a protein through disulfide-bond formation between cysteine residues. In a cell, disulfide-catalysts such as protein disulfide isomerase promote the oxidative protei
Externí odkaz:
https://doaj.org/article/e3dec673a4154596aef5210e66455dd8
Publikováno v:
Redox Biology, Vol 7, Iss C, Pp 14-20 (2016)
Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys94, Cys99, Cys394, Cys397), Ero1α harbors four regulatory cysteines (Cys104, Cys131, Cys208, Cys241). Th
Externí odkaz:
https://doaj.org/article/d1b1d27844474dafb2faf9dd7124299f