Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Masaki Ohyagi"'
Autor:
Marenori Kojima, Katsuya Suzuki, Masaru Takeshita, Masaki Ohyagi, Mana Iizuka, Humitsugu Yamane, Keiko Koga, Taku Kouro, Yoshiaki Kassai, Tomoki Yoshihara, Ryutaro Adachi, Kentarou Hashikami, Yuichiro Ota, Keiko Yoshimoto, Yuko Kaneko, Rimpei Morita, Akihiko Yoshimura, Tsutomu Takeuchi
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract T cells play important roles in autoimmune diseases, but it remains unclear how to optimally manipulate them. We focused on the T cell immunoreceptor with Ig and ITIM domains (TIGIT), a coinhibitory molecule that regulates and is expressed i
Externí odkaz:
https://doaj.org/article/f0cee47f61f749aca6573a414bdab36e
Autor:
Hidetoshi Kaburagi, Tetsuya Nagata, Mitsuhiro Enomoto, Takashi Hirai, Masaki Ohyagi, Kensuke Ihara, Kie Yoshida-Tanaka, Satoe Ebihara, Ken Asada, Hiroyuki Yokoyama, Atsushi Okawa, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 910-919 (2022)
Neuropathic pain, a heterogeneous condition, affects 7%–10% of the general population. To date, efficacious and safe therapeutic approaches remain limited. Antisense oligonucleotide (ASO) therapy has opened the door to treat spinal muscular atrophy
Externí odkaz:
https://doaj.org/article/22296da924d746c2af59bc6a87710a40
Autor:
Masaki Ohyagi, Tetsuya Nagata, Kensuke Ihara, Kie Yoshida-Tanaka, Rieko Nishi, Haruka Miyata, Aya Abe, Yo Mabuchi, Chihiro Akazawa, Takanori Yokota
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Using gene silencing to regulate lymphocyte function is a promising therapeutic approach for autommunity, inflammation and cancer. Here the authors use a heteroduplex oligonucleotide for improved potency, efficacy and longer retention times.
Externí odkaz:
https://doaj.org/article/4b4fe927fe694d8682d8833aabacf921
Autor:
Shinichi Yamamoto, Ako Matsui, Masaki Ohyagi, Chie Kikutake, Yoshihiro Harada, Mana Iizuka-Koga, Mikita Suyama, Akihiko Yoshimura, Minako Ito
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cells (Tregs) are normally born in the thymus and activated in secondary lymphoid tissues to suppress immune responses in the lymph node and at sites of inflammation. Tregs are also resident in various tissues or accumulate in damaged ti
Externí odkaz:
https://doaj.org/article/b0b43ec9b97f436aab7b07d41aab01cf
Autor:
Setsuko Mise-Omata, Mari Ikeda, Masaru Takeshita, Yoshifumi Uwamino, Masatoshi Wakui, Tomoko Arai, Ayumi Yoshifuji, Kensaku Murano, Haruhiko Siomi, Kensuke Nakagawara, Masaki Ohyagi, Makoto Ando, Naoki Hasegawa, Hideyuki Saya, Mitsuru Murata, Koichi Fukunaga, Ho Namkoong, Xiuyuan Lu, Sho Yamasaki, Akihiko Yoshimura
Publikováno v:
The Journal of Immunology. 209:2104-2113
Although the immunological memory produced by BNT162b2 vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well studied and established, further information using different racial cohorts is necessary to understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a407a5ad119d5d9709416c62fe25dd2
https://doi.org/10.4049/jimmunol.2200525
https://doi.org/10.4049/jimmunol.2200525
Autor:
Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Kotaro Yoshioka, Naoto Arimura, Takanori Yokota, Frank Rigo, Toshiki Uchihara, Takashi Ishii, Kensuke Ihara, Kenichi Miyata, Haruka Miyata, Takeshi Wada, Kanjiro Miyata, Chrissa A. Dwyer, Punit P. Seth, Tetsuya Nagata, Rintaro Iwata Hara, Syunsuke Yamamoto, Hideki Hirabayashi, Satoe Ebihara, Tomoko Igari, C. Frank Bennett, Masaki Ohyagi, Berit Powers
Publikováno v:
Nature Biotechnology. 39:1529-1536
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dbc680bd2292680a38bb270a82d4
https://doi.org/10.1038/s41587-021-00972-x
https://doi.org/10.1038/s41587-021-00972-x
Publikováno v:
Advances in Immunology; 2023, Vol. 157, p29-58, 30p
Publikováno v:
Mol Ther
Microglial activation followed by recruitment of blood-borne macrophages into the central nervous system (CNS) aggravates neuroinflammation. Specifically, in multiple sclerosis (MS) as well as in experimental autoimmune encephalomyelitis (EAE), a rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5919bb7786eee89841d241d246d3aa4b
https://pubmed.ncbi.nlm.nih.gov/35189344
https://pubmed.ncbi.nlm.nih.gov/35189344
Autor:
Masaki Ohyagi, Takuya Ohkubo, Takashi Taniyama, Shoji Tomizawa, Atsushi Okawa, Takanori Yokota, Hidehiro Mizusawa
Publikováno v:
Journal of Global Infectious Diseases, Vol 4, Iss 2, Pp 132-134 (2012)
Spinal epidural abscess (SEA) is a rare infection complicated in patients who have some risk factors such as injection-drug use, diabetes mellitus, and several illnesses. However, no case of SEA associated with abortion has been reported. Here we rep
Externí odkaz:
https://doaj.org/article/9bda03276fe8473ba6323ddcc773f0a0
Autor:
Takanori Yokota, Eiichiro Amano, Hiroya Kuwahara, Akira Machida, Takashi Irioka, Takuya Ohkubo, Masaki Ohyagi, Yuko K Takahashi, Satoru Ishibashi
Publikováno v:
Internal Medicine
Objective Cryptococcal meningoencephalitis (CM) causes significant morbidity and mortality in human immunodeficiency virus (HIV)-negative and HIV-positive populations. White matter lesions (WMLs) have been reported in both populations of CM patients;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447b1fc15004e7b5c08411bb9d470147
http://europepmc.org/articles/PMC6875458
http://europepmc.org/articles/PMC6875458