Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Masaki Kumondai"'
Autor:
Masaki Kumondai, Reika Ogawa, Nagomi Hayashi, Yurika Ishida, Hanae Oshikiri, Yuji Sato, Masafumi Kikuchi, Yu Sato, Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Lenvatinib (LEN), a multitarget tyrosine kinase inhibitor used in various cancer treatments, is mainly metabolized by cytochrome P450 3A (CYP3A) enzymes. The importance of therapeutic drug monitoring (TDM) in patients administered LEN has be
Externí odkaz:
https://doaj.org/article/3c3b7eda38744636833b54cae65ec9d1
Autor:
Masahiro Watanabe, Masamitsu Maekawa, Keitaro Miyoshi, Toshihiro Sato, Yu Sato, Masaki Kumondai, Masayoshi Fukasawa, Nariyasu Mano
Publikováno v:
Metabolites, Vol 14, Iss 10, p 515 (2024)
Background: Niemann-Pick disease type C (NPC) is an inherited disorder characterized by a functional deficiency of cholesterol transport proteins. However, the molecular mechanisms and pathophysiology of the disease remain unknown. Methods: In this s
Externí odkaz:
https://doaj.org/article/3ff37a64e698467e9c8910ecc6474854
Autor:
Minami Yamauchi, Masamitsu Maekawa, Toshihiro Sato, Yu Sato, Masaki Kumondai, Mio Tsuruoka, Jun Inoue, Atsushi Masamune, Nariyasu Mano
Publikováno v:
Metabolites, Vol 14, Iss 9, p 513 (2024)
Imaging tests, tumor marker (TM) screening, and biochemical tests provide a definitive diagnosis of hepatocellular carcinoma (HCC). However, some patients with HCC may present TM-negative results, warranting a need for developing more sensitive and a
Externí odkaz:
https://doaj.org/article/f6e718526f93447587c02a0a64d33fa2
Autor:
Yu Sato, Hiroki Kondo, Yuji Sato, Ai Abe, Masafumi Kikuchi, Toshihiro Sato, Masaki Kumondai, Kohei Yoshikawa, Yoshihiro Hayakawa, Masamitsu Maekawa, Nariyasu Mano
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1138 (2024)
Therapeutic drug monitoring (TDM) is a personalized treatment approach that involves optimizing drug dosages based on patient-specific factors, such as drug plasma concentrations, therapeutic efficacy, or adverse reactions. The plasma concentration o
Externí odkaz:
https://doaj.org/article/797592a7facb4fbb992499f588035371
Autor:
Tensei Hirasawa, Masafumi Kikuchi, Shinya Takasaki, Masaki Kumondai, Yu Sato, Toshihiro Sato, Eishi Imoto, Yoshihiro Hayakawa, Masamitsu Maekawa, Nariyasu Mano
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16926- (2023)
Many types of oral molecular-targeted anticancer drugs are clinically used in cancer genomic medicine. Combinations of multiple molecular-targeted anticancer drugs are also being investigated, expecting to prolong the survival of patients with cancer
Externí odkaz:
https://doaj.org/article/5548934ceb984d27b8cf4fd6c31ce6d8
Autor:
Masaki Kumondai, Masamitsu Maekawa, Eiji Hishinuma, Yu Sato, Tshihiro Sato, Masafumi Kikuchi, Masahiro Hiratsuka, Nariyasu Mano
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:455-463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceafbead55edb94b4267c88561e6b6e
https://doi.org/10.1248/bpb.b22-00840
https://doi.org/10.1248/bpb.b22-00840
Autor:
Masaki Kumondai, Masafumi Kikuchi, Atsushi Mizuguchi, Nagomi Hayashi, Masahiro Ui, Takashi Hirama, Yoshinori Okada, Yu Sato, Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano
Publikováno v:
The Tohoku Journal of Experimental Medicine. 260:29-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee78afc82d418ff74736a5c3d892a40
https://doi.org/10.1620/tjem.2023.j016
https://doi.org/10.1620/tjem.2023.j016
Autor:
Akihiro Saito, Masafumi Kikuchi, Yuko Matsumoto, Erina Sugawara, Gesshu Takao, Hayato Inomata, Akane Takahashi, Yuji Sato, Masaki Kumondai, Yu Sato, Toshihiro Sato, Masashi Ninomiya, Jun Inoue, Masamitsu Maekawa, Nariyasu Mano
Publikováno v:
Therapeutic Drug Monitoring. 44:771-776
The anticancer drug, Lenvima (lenvatinib), has severe side effects. Therapeutic drug monitoring helps ensure its efficacy and safety. Regular and optimally timed blood sampling is tough, especially when lenvatinib is self-medicated. Microsampling usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1847664b9382cab7c9a95e22ab9fb24e
https://doi.org/10.1097/ftd.0000000000001013
https://doi.org/10.1097/ftd.0000000000001013
Autor:
Masamitsu, Maekawa, Keitaro, Miyoshi, Aya, Narita, Toshihiro, Sato, Yu, Sato, Masaki, Kumondai, Masafumi, Kikuchi, Katsumi, Higaki, Torayuki, Okuyama, Yoshikatsu, Eto, Hiroshi, Sakamaki, Nariyasu, Mano
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1259-1268
As Niemann-Pick disease type C (NPC) is difficult to diagnose owing to its various clinical symptoms; biomarker tests have been developed. Previously, we revealed urinary sulfated cholesterol metabolites as noninvasive biomarkers for NPC. However, LC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6facc513065b274d84f6aa20f7935063
https://doi.org/10.1248/bpb.b22-00185
https://doi.org/10.1248/bpb.b22-00185
Autor:
Ai Abe, Akiko Ueda, Masahiro Hiratsuka, Nariyasu Mano, Shu Tadaka, Evelyn Marie Gutiérrez Rico, Sakae Saito, Daisuke Saigusa, Kengo Kinoshita, Eiji Hishinuma, Masamitsu Maekawa, Noriyasu Hirasawa, Akifumi Oda, Tomoki Nakayoshi, Masaki Kumondai
Publikováno v:
Drug Metabolism and Disposition. 49:212-220
CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs. Therefore, interindividual variability in CYP3A4 activity is a frequent cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5634f5e3e0e8eafaf2f3ce1336327c72
https://doi.org/10.1124/dmd.120.000261
https://doi.org/10.1124/dmd.120.000261