Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Masaki KAMEYAMA"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Parkinson’s disease (PD), a common neurodegenerative disease characterized by motor dysfunction, results from the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Although the precise causes of PD are still unknown, severa
Externí odkaz:
https://doaj.org/article/4c09731535dd494ca64d97df983e2fca
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 187-194 (2018)
Activity of cardiac Cav1.2 channels is enhanced by cyclic AMP-PKA signaling. In this study, we studied the effects of PKA phosphorylation on the binding of calmodulin to the fragment peptide of the proximal C-terminal tail of α1C subunit (CT1, a.a.
Externí odkaz:
https://doaj.org/article/de87824c033c48a2997242118944e138
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 4, Pp 240-246 (2017)
Cardiac Cav1.2 channels, coupling membrane stimulation to intracellular Ca2+ signaling, are regulated by multiple cytoplasmic factors, such as calmodulin (CaM), phosphorylation, Ca2+, ATP and intramolecular fragments of the channel. The interaction b
Externí odkaz:
https://doaj.org/article/37ed073995fc4052a1d55fefaf29f8c9
Autor:
Yoshio YOSHIKUWA, Haruyuki KOMETANI, Yoshinori MIYAMOTO, Masaki KAMEYAMA, Manabu DEGUCHI, Toshihiko MIZUTANI
Publikováno v:
Nihon Kikai Gakkai ronbunshu, Vol 84, Iss 861, Pp 17-00450-17-00450 (2018)
Motors are used in many appliances, and noise reduction is strongly demanded. One of the main causes of noise is electromagnetic excitation force and it is well known that the excitation force is increased by the eccentricity of the rotor to the stat
Externí odkaz:
https://doaj.org/article/f35be1dc54a544ddb8016fa129934c3c
Autor:
Meimi Zhao, Rui Feng, Dongxue Shao, Shuyuan Liu, Ming Lei, Hongmei Wang, Xuefei Sun, Feng Guo, Huiyuan Hu, Masaki Kameyama, Liying Hao
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 3, Pp 143-149 (2015)
This study aimed to investigate the intracellular Mg2+ regulation of the L-type Ca2+ channels in guinea pig ventricular myocytes. By adopting the inside-out configuration of the patch clamp technique, single channel currents of the L-type Ca2+ channe
Externí odkaz:
https://doaj.org/article/cdbe2d1cba1a42c18af7429e014154e5
Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 137-143 (2015)
Although it has been well documented that redox can modulate Cav1.2 channel activity, the underlying mechanisms are not fully understood. In our study, we examined the effects of redox on Cav1.2 channel activity and on CaM interaction with the Cav1.2
Externí odkaz:
https://doaj.org/article/59f027f48aee4e559695587c156e092a
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 4, Pp 397-404 (2010)
Although calmodulin binding to various sites of the Cav1.2 Ca2+ channel has been reported, the mechanism of the interaction is not fully understood. In this study we examined calmodulin binding to fragment channel peptides using a semi-quantitative p
Externí odkaz:
https://doaj.org/article/4d21783f778f430b9811f0ce841ad959
Autor:
Dong-Yun Han, Etsuko Minobe, Wu-Yang Wang, Feng Guo, Jian-Jun Xu, Li-Ying Hao, Masaki Kameyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 3, Pp 310-319 (2010)
The L-type Ca2+ channel (Ca V 1.2) shows clear Ca2+-dependent facilitation and inactivation. Here we have examined the effects of calmodulin (CaM) and Ca2+ on Ca2+ channel in guinea-pig ventricular myocytes in the inside-out patch mode, where rundown
Externí odkaz:
https://doaj.org/article/9742e5767dff4ab78135ee3d4bf1508e
Autor:
Li-Ying Hao, Wu-Yang Wang, Etsuko Minobe, Dong-Yun Han, Jian-Jun Xu, Asako Kameyama, Masaki Kameyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 4, Pp 416-425 (2009)
In this study, we investigated the roles of calmodulin kinase II (CaMKII) and calmodulin (CaM) in the reversal of run-down of L-type Ca2+ channels. Single Ca2+-channel activities in guinea-pig ventricular myocytes were recorded using the patch-clamp
Externí odkaz:
https://doaj.org/article/57faa8652fe141c281356f308b6de87c
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 290-300 (2008)
The roles of calmodulin (CaM)-dependent protein kinase II (CaMKII) in the maintenance of basal activity and the reversion of run-down of L-type Ca2+ channels were studied in guinea-pig ventricular myocytes by the patch-clamp technique. In the cell-at
Externí odkaz:
https://doaj.org/article/946b2934b835407cbd79c37af208e954