Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Masaki Hagihara"'
Autor:
Yousuke Katsuda, Takuto Kamura, Tomoki Kida, Takeru Saeki, Yua Itsuki, Yuri Kato, Taishi Nakamura, Motohiro Nishida, Yusuke Kitamura, Toshihiro Ihara, Masaki Hagihara, Shin-ichi Sato
Summary paragraphThe elucidation of gene-silencing mechanisms by RNA interference (RNAi) and antisense oligomers has drawn increasing attention to nucleic acid medicine. However, several challenges remain to be overcome, such as in vivo stability1, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b24f0a9636cd3c542cb0e6a32d28e9
https://doi.org/10.1101/2023.04.18.537290
https://doi.org/10.1101/2023.04.18.537290
Autor:
Tomonori Shibata, Chikara Dohno, Yuta Hishinuma, Kaoru Saito, Masaki Hagihara, Kazuhiko Nakatani, Kazuhiro Sugimoto, Yuri Sohma
Publikováno v:
Chemistry Letters. 50:1848-1851
We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis...
Publikováno v:
Chemistry Letters. 50:1806-1809
Here we demonstrate that a guanine-to-adenine substitution within guanine repeat sequences in the MSH 5′-UTR weakens G-quadruplex stability, leading to increased protein synthesis. The abnormal pro...
Autor:
Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto, Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, Yoshiki Oosawatsu, Kenji Yatsuzuka, Yusuke Kitamura, Masaki Hagihara, Toshihiro Ihara, Motonari Uesugi
Publikováno v:
Nucleic acids research. 50(14)
Tandem repeats of guanine-rich sequences in RNA often form thermodynamically stable four-stranded RNA structures. Such RNA G-quadruplexes have long been considered to be linked to essential biological processes, yet their physiological significance i
Autor:
Nursakinah Mohd Zaifuddin, Mizuki Nihei, Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiko Nakatani
Publikováno v:
Chemical Communications. 57:3235-3238
We demonstrated that a synthetic ligand NA, which selectively binds to a 5′-CAG-3′/5′-CAG-3′ triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophore
Autor:
Masaki Hagihara
Publikováno v:
Chemical communications (Cambridge, England). 57(65)
We demonstrate that an RNA template containing eight GGG repeat sequences exhibits a unique tandem G-quadruplex structure in which two individual G-quadruplexes are aligned in close proximity. Because of their unexpected stability, tandem G-quadruple
Autor:
Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiro Sugimoto, Yuta Hishinuma, Yuri Sohma, Tomonori Shibata, Kazuhiko Nakatani
Publikováno v:
Chemistry Letters; Nov2021, Vol. 50 Issue 11, p1848-1851, 4p
Autor:
Yoshitaka Morimura, Yousuke Katsuda, Hiroshi Sugiyama, Shinichi Sato, Lisa Asano, Tomoyuki Furuta, Masaki Hagihara, Motonari Uesugi
Publikováno v:
Journal of the American Chemical Society. 138:9037-9040
The G-quadruplexes form highly stable nucleic acid structures, which are implicated in various biological processes in both DNA and RNA. Although DNA G-quadruplexes have been studied in great detail, biological roles of RNA G-quadruplexes have receiv
Autor:
Atsuya Momotake, Tomokazu Shibata, Yusaku Nakayama, Yasuhiko Yamamoto, Hikaru Hemmi, Takako Ohyama, Haruka Araki, Kosuke Hayasaka, Kentaro Ochi, Masaki Hagihara, Ryosuke Shinomiya
Publikováno v:
SC30201812260003
NARO成果DBd
NARO成果DBd
Heme in its ferrous and ferric states [heme(Fe2+) and heme(Fe3+), respectively] binds selectively to the 3′-terminal G-quartet of all parallel-stranded monomeric G-quadruplex DNAs formed from inosine(I)-containing sequences, i.e., d(TAGGGTGGGTTGGGT
Autor:
Masayuki Morikawa, Kentaro Takahama, Takanori Oyoshi, Katsuhito Kino, Takumi Shitara, Keita Mitsuya, Ayumu Yamamoto, Arisa Miyawaki, Masaki Hagihara
Publikováno v:
ACS Chemical Biology. 10:2564-2569
Human telomere DNA (Htelo) and telomeric repeat-containing RNA (TERRA) are integral telomere components containing the short DNA repeats d(TTAGGG) and RNA repeats r(UUAGGG), respectively. Htelo and TERRA form G-quadruplexes, but the biological signif