Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Masaki Daini"'
1
Akademický článek
Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome
Autor: Li Zhang, Genay Pilarowski, Emilio Merlo Pich, Atsushi Nakatani, John Dunlop, Rina Baba, Satoru Matsuda, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Haruhide Kimura, Hans Tomas Bjornsson
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 779-791 (2021)
Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha
Externí odkaz: https://doaj.org/article/6bb431629e2043e29d57edb98e0cfd0f
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2
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore
Autor: Yuta Tanaka, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki
Publikováno v: Journal of Medicinal Chemistry. 65:4270-4290
Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407ff68d50cb206d4c182ef36b2c1cf
https://doi.org/10.1021/acs.jmedchem.1c02078
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3
Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects
Autor: Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito
Publikováno v: European journal of medicinal chemistry. 239
Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1799e4688154809d1d4f50bf466e86b
https://pubmed.ncbi.nlm.nih.gov/35749987
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5
LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models
Autor: Ryuji Yamada, Mitsuhiro Ito, Hideyuki Oki, Yasushi Hattori, Yuuichi Arakawa, Matsumoto Shigemitsu, Satoru Matsuda, Atsushi Nakatani, Masaki Daini, Shigeru Igaki, Noriko Suzuki, Haruhide Kimura, Tatsuya Ando, Rina Baba
Publikováno v: Science Advances
LSD1 inhibitor TAK-418 could be a therapeutic option for neurodevelopmental disorders via normalization of gene expression.
Persistent epigenetic dysregulation may underlie the pathophysiology of neurodevelopmental disorders, such as autism spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226b60276736066095731de4a03ae505
https://doi.org/10.1126/sciadv.aba1187
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6
Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome
Autor: Mitsuhiro Ito, Genay Pilarowski, John Dunlop, Li Zhang, Yasushi Hattori, Rina Baba, Hans T. Bjornsson, Haruhide Kimura, Masaki Daini, Atsushi Nakatani, Satoru Matsuda, Matsumoto Shigemitsu, Emilio Merlo Pich
Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 779-791 (2021)
Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adbc4df2183c0c5d1a5a586542ec76a
https://doi.org/10.1101/2020.03.11.986976
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7
Nickel-Catalyzed Cyclizativetrans-Carboboration of Alkynes through Activation of Boron-Chlorine Bonds by Using Organometallic Reagents as Donors of Organic Groups
Autor: Masaki Daini, Akihiko Yamamoto, Michinori Suginome
Publikováno v: Asian Journal of Organic Chemistry. 2:968-976
Cyclizative alkynylboration and alkenylboration of carbon–carbon triple bonds proceeds in the presence of a nickel catalyst. Chloroboranes bearing homopropargyloxy or bishomopropargyloxy groups were used as substrates with alkynylstannane, vinylsta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44e1f6a3bad6a5e67863d6026a999ab3
https://doi.org/10.1002/ajoc.201300164
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8
Palladium-Catalyzed, Stereoselective, Cyclizative Alkenylboration of Carbon−Carbon Double Bonds through Activation of a Boron−Chlorine Bond
Autor: Masaki Daini, Michinori Suginome
Publikováno v: Journal of the American Chemical Society. 133:4758-4761
Palladium-catalyzed alkenylboration of carbon-carbon double bonds has been achieved using the reaction of chloro(diisopropylamino)boryl ethers of homoallylic alcohols with alkenylzirconium reagents. The reaction may proceed through an initial oxidati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9a4c65c8e5b2a429f236549d7f8164
https://doi.org/10.1021/ja200856t
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9
Ruthenium-Catalyzed Dienyne Formation from Propargylic Alcohols and 1,3-Conjugated Dienes
Autor: Sakae Uemura, Yoshihiro Miyake, Ken Sakata, Keiichiro Kanao, Masato Yoshikawa, Masaki Daini, Youichi Inada, Yoshiaki Nishibayashi
Publikováno v: Organometallics. 27:2046-2051
Ruthenium-catalyzed carbon−carbon bond forming reactions between propargylic alcohols and acyclic and cyclic 1,3-conjugated dienes give the corresponding dienyne compounds in good to high yields. Only the use of thiolate-bridged diruthenium complex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73b16e49358af35945866f7ee8968711
https://doi.org/10.1021/om800075e
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10
Palladium-catalyzed Carboboration: Borylative Coupling of Alkynes with Alkenes through Activation of Boron–Chlorine Bonds
Autor: Masaki Daini, Kanayo Nakada, Michinori Suginome
Publikováno v: Chemistry Letters. 42:538-540
Alkynes tethered to a chloro(diisopropylamino)boryl group undergo palladium-catalyzed borylative coupling with styrenes and acrylates, giving substituted cyclic 1,3-dienylboronic acid derivatives i...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61c686fcddd8d92072e42a20c117eb56
https://doi.org/10.1246/cl.130131
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